Cedric Boeckx

A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.

Good stuff 👍. I’m sure you’ll be a great PI/mentor

Genomic convergence in hibernating mammals elucidates the genetics of metabolic regulation in the hypothalamus Extreme metabolic adaptations can elucidate genetic programs that govern mammalian metabolism. Here, we used convergent evolutionary changes in hibernating lineages to define conserved cis-regulatory ...

Two great genomics studies in @science.org uncovering the regulatory architecture underlying hibernation 🧪🧬
(First paper is an excellent example of comparative genomics to capture convergence across distant species)
1.
www.science.org/doi/10.1126/...
2.
www.science.org/doi/10.1126/...

Fantastic demonstration of the power of comparative genomics across large phylogenies to discover the mechanistic basis of a convergently evolved trait, hibernation
www.science.org/doi/10.1126/...

Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines - Nature Methods The analysis presented in this Brief Communication shows that, despite their complexity, current deep learning models do not outperform linear baselines in predicting gene perturbation effects, thus e...

An analysis shows that current deep learning models do not beat linear baselines in predicting gene perturbation effects, thus emphasizing the importance of further method development and evaluation. @const-ae.bsky.social @wkhuber.bsky.social @s-anders.bsky.social

www.nature.com/articles/s41...

Integrating and interpreting brain maps | doi.org/10.1016/j.ti...

Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️

Human neurons undergo protracted functional maturation into adulthood Human cognitive development is uniquely prolonged, reflecting the extended postnatal maturation of the cerebral cortex where cell-type differentiation, synaptogenesis, myelination8 and transcriptional...

Beautiful work from the Raimondo lab documenting the protracted maturation of human neurons (h/t @lancasterlab.bsky.social)
For #neoteny fans 🧪🧠
www.biorxiv.org/content/10.1...

Nice preprint on the neuroscience of cross-modality 🧪🧠
👇

1/N What are the organizational principles underlying crossmodal cortical connections?
We address this in this new preprint, led by @alexegeaweiss.bsky.social & ‪@bturner-bridger.bsky.social‬ in collab w/ ‪@petrznam.bsky.social‬ @crick.ac.uk
www.biorxiv.org/content/10.1...

Human neurons undergo protracted functional maturation into adulthood Human cognitive development is uniquely prolonged, reflecting the extended postnatal maturation of the cerebral cortex where cell-type differentiation, synaptogenesis, myelination8 and transcriptional...

Beautiful work from the Raimondo lab documenting the protracted maturation of human neurons (h/t @lancasterlab.bsky.social)
For #neoteny fans 🧪🧠
www.biorxiv.org/content/10.1...

Congratulations @noranewcombe.bsky.social 👏👏

Sensory modality-specific wiring of thalamocortical circuits - Nature Reviews Neuroscience The use of transcriptomic technologies has led to advances in our understanding of thalamocortical targeting during development. In this Review, Guillamón-Vivancos et al. discuss these advances in the...

Sensory modality-specific wiring of thalamocortical circuits — a Review by Teresa Guillamón-Vivancos, Mar Aníbal-Martínez, Lorenzo Puche-Aroca, Francisco J. Martini & Guillermina López-Bendito

@guillelbendito.bsky.social @glb-lab.bsky.social

#neuroscience

www.nature.com/articles/s41...

A hypothalamic circuit that modulates feeding and parenting behaviours - Nature Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.

Terrific study, led by @ivancalcantara.bsky.social, on the neural circuitry underlying the prioritisation of competing motivated behaviors, out in @nature.com
🧪🧠
www.nature.com/articles/s41...

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...

Great resource, out today in @natneuro.nature.com:
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
@stephaniehicks.bsky.social @martinowk.bsky.social & colleagues
🧪🧠🧬
www.nature.com/articles/s41...

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...

Great resource, out today in @natneuro.nature.com:
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
@stephaniehicks.bsky.social @martinowk.bsky.social & colleagues
🧪🧠🧬
www.nature.com/articles/s41...

A hypothalamic circuit that modulates feeding and parenting behaviours - Nature Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.

Terrific study, led by @ivancalcantara.bsky.social, on the neural circuitry underlying the prioritisation of competing motivated behaviors, out in @nature.com
🧪🧠
www.nature.com/articles/s41...

Congrats!

🧠 Opportunity for a post-doctoral position on human neurobiology, funded by the @erc.europa.eu!
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...

Very nice study. Congrats to everyone involved 👏

Congratulations. Very nice work 👏

First large-scale GWAS of stuttering 🧪🧬:

Very nice new study led by @k4tj4.bsky.social & @r3rt0.bsky.social

Brains, behaviors, phylogeny & developmental constraints 🧪🧠

Thread 👇

This looks like an impressive symposium on #organoids (h/t @sergiuppasca.bsky.social)
Stellar speaker line-up; Osaka, January 2026
🧪🧫
www.takeda-pharma.jp/program.html

Predicting the direction of phenotypic difference - Nature Communications Here authors reveal a method to predict key information on phenotypes - their direction. This is achievable even for phenotypes with incomplete genotype-to-phenotype mapping, and applicable for indivi...

Cool new approach by @david-gokhman.bsky.social @gilig.bsky.social @shaicarmi.bsky.social, seeking to extract more phenotypic information from genotypes & make accurate predictions concerning the direction of phenotypic difference 🧪🧬
@natcomms.nature.com

Congrats!

Archaic ancestry inference in imputed ancient human genomes When modern humans expanded from Africa into Eurasia, they interbred with archaic hominins such as Neanderthals and Denisovans. This groundbreaking discovery, made in part possible through the genomic...

Interesting new approach developed by @marcocapo.bsky.social and Emilia Huerta-Sanchez to gain new insight into introgression events: Archaic ancestry inference in imputed ancient human genomes 🧪🧬

www.biorxiv.org/content/10.1...

Charting structural brain asymmetry across the human lifespan Lateralization is a fundamental principle of structural brain organization. In vivo imaging of brain asymmetry is essential for deciphering lateralized brain functions and their disruption in neurodev...

Terrific new preprint charting structural brain asymmetry across the human lifespan
By @aarona-b.bsky.social and collaborators 🧪🧠

www.biorxiv.org/content/10.1...

Terrific work!👏👏

Congrats @dcsoto.bsky.social @jmuribescr.bsky.social @mydennis.bsky.social 👏👏

Outstanding work by @dcsoto.bsky.social @jmuribescr.bsky.social @mydennis.bsky.social (and other collaborators) that massively advances identification of human gene duplicates, with links to important traits and our evolution. So happy to have contributed a bit to this fantastic paper.