Paul K. Sue, MDCM FIDSA, FPIDS

Large Language Model Influence on Diagnostic Reasoning This randomized clinical trial evaluates the diagnostic performance of physicians with use of a large language model compared with conventional resources.

A friend sent this article to me today.

It feels like a good moment to remind us: the LLM outperformed physicians on STRUCTURED cases.

Someday the AIs may perform better than us in the unstructured, messy, real-world patient encounter...but that day is not today.🩺🛟

jamanetwork.com/journals/jam...

Donor-derived Mycoplasma and Ureaplasma infections in lung transplant recipients: A prospective study of donor and recipient respiratory tract screening and recipient outcomes Mycoplasma hominis and Ureaplasma species are urogenital mollicutes that can cause serious donor-derived infections in lung transplant recipients. Best practices for mollicute screening remain unknown...

This is a nice and informative prospective study of donor-derived Mycoplasma and Ureaplasmain lung transplant recipients from our Duke Colleagues. Nicely done Patrick Tam! #TxID #IDSky www.amjtransplant.org/article/S160...

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...

🔥BALANCE RCT🔥
74 hospitals in 7 countries
3,608 patients
A 7-day course of antibiotics for hospitalized patients with bloodstream infections was non inferior to 14d within a 4% prespecified margin for mortality at 90 days #idsky
www.nejm.org/doi/full/10....

Use of 2024-2025 COVID-19 Vaccines ... This report describes the Advisory Committee on Immunization Practices’ recommendations for the 2024-25 COVID-19 vaccines.

💉 For my #PedsTID friends >> wondering if folks are advocating multiple doses of the 2024-2025 COVID19 booster for your previously fully 💉 #Immunocompromised 👶? If so, how many more? 🙏 www.cdc.gov/mmwr/volumes...

🆕️🔥Treatment of Invasive Pulmonary Aspergillosis and Preventive and Empirical Therapy for Invasive Candidiasis in Adult Pulmonary and Critical Care Patients. An Official American Thoracic Society Clinical Practice Guideline #idsky
www.atsjournals.org/doi/abs/10.1...

Got a cool #TxID case?

Let @maricarmalinis.bsky.social know! See below for more details.

👍Fantastic study 👀 at whether #shorterisbetter in Neutropenic Bacteremia in adults. >80% GNB with almost 18% MDRO, profound neutropenia in 83% of enrollees & post therapy Abx PPX in 65%. Adequate source control in 70%-100%. No diff in relapse or ☠️ if <10 vs > 10 ABX days. #IDSky #TIDSky

Want to learn about the treatment of RVI in immunocompromised patients?

Join us for the next @ESCMID.bsky.social ESGICH/ESGREV webinar on the treatment of RVI.

Chairs: Hans Hirsch and @michaelisonmd.bsky.social

Talks by: Pauline Vetter, Jose Luise Pinana, Fareed Khawaja

How to not be completely wrong about air filters A new RCT of HEPA filters for residential care homes gets heads spinning

Excellent analysis of what happens when a clinical trial is under powered. In this example, it's the use of air purifiers in nursing homes and preventing respiratory tract infections.

Results suggest it might work. Or it might not.
@apsmunro.bsky.social

open.substack.com/pub/alasdair...

💩 Ugh -- ".. only 12.1% of NDM-producing isolates were susceptible to cefiderocol using the 2024 EUCAST version 14.0 DD breakpoint. Ceftazidime/avibactam and aztreonam synergy was seen in 87.5% of isolates tested..." In some settings, empiric use in MBL -producing isolates may be inappropriate...

IDSA Immunocompromised Host Community of Practice The purpose of the Immunocompromised Host Community of Practice (COP) is to create a community that

The @idsainfo.bsky.social IHCOP welcomes all who are involved in the care of immunocompromised hosts. We have a great opportunity to advance the field, build and sustain the TID workforce. Please sign
Up 🤓 my.idsociety.org/volunteeropp...

The preliminary sequence from the H5N1 human case in British Columbia has been posted and it is not good news. The virus potentially has a quasispecies at HA residue 226 (H3 numbering). This is bad news because we know that mutations at residue 226 can increase binding to human receptors. 1/

US health officials report 1st case of new form of mpox in a traveler Health officials say they have confirmed the first U.S. case of a new form of mpox that was first seen in eastern Congo.

Health officials in California have confirmed the first case of mpox clade I in the US. Patient is a returning traveller's who traveled to eastern Africa. This is not unexpected because the world is interconnected and there are ongoing outbreaks of clade I mpox in Africa.
apnews.com/article/mpox...

We have found the opposite 2 be true during this 👶outbreak. Incorrectly obtained NP swabs (not reaching the OP) have been false (+) 2 begin w/ only to turn (+) when retested in the PICU. And kids w/ progression on empiric S.pneumo, GAS & Staph coverage have ultimately required Azithro + steroids.

Great point!

We often advocate for a unifying diagnosis (Occam’s razor), but in people with immunocompromise, it’s important not to disregard Hickam’s dictum; “Patients can have as many diseases as they damn well please!”

#Medsky #IDSky #TxIDSky

pommel horse guy from us olympics mens gymnastics team resting with his eyes closed before his turn to compete at the olympics

All pediatricians and infectious diseases doctors right now
#PedsSky #IDSky #MedSky

The US confirmed #H5N1 #birdflu count is now 52, from 7 states. 58% due to exposure to infected cows, 40% to infected poultry. The mystery Missouri case rounds out the mix. To date all cases have been mild. www.cdc.gov/bird-flu/sit...

a baby is sitting in a high chair making a surprised face and saying wow . ALT: a baby is sitting in a high chair making a surprised face and saying wow .

We can pin #TxID content? Amazing!!! Thanks @germhuntermd.bsky.social !!

Thanks 4 this Ilan!! 😍😍😍

a white cat is laying on its back with the words hello there in the background ALT: a white cat is laying on its back with the words hello there in the background

🤔Hmm...new here. Anyone else around? How is the neighborhood? #PedsTID #WeAreID #TransplantID #IDSA #JPIDS #ASTIDCOP #ASTCT #IPTA