Oncology Clinical Trials Office

The MILI trial aims to determine whether a medication called metformin will reduce the chance of developing cancer in people with LFS.

To learn more about the MILI trial and LFS, visit mili.octru.ox.ac.uk and The George Pantziarka TP53 Trust: tp53.co.uk/lfs-tp53/

The MILI site team based in Leicester Royal Infirmary share why working with clinical trials is important to them.
Find out more about MILI here: mili.octru.ox.ac.uk

#LFS #TP53 #LiFraumeniSyndrome #LeicesterRoyalInfirmary

A quotation from a Research Nurse at Aberdeen Royal Infirmary working on the MILI trial says, "The possibility of discovering medication that will reduce the incidence of cancer is exciting and will change the lives of many patients living with the condition".

The MILI site team based at Aberdeen Royal Infirmary share what this study means to them.
Find out more about MILI here: mili.octru.ox.ac.uk
#LFS #TP53 #LiFraumeniSyndrome @NHSGrampian

MILI Trial – FAQs Frequently Asked Questions for the MILI Trial Eligibility and trial participation My whole-body MRI scan is more than 3 months old, can I still be enrolled into the trial? No, however if may be pos…

‘The GPTP53 trust have published some more information about the MILI trial.

Visit their website to find out more: www.tp53.org.uk/mili-trial-f...

#LFS #LiFraumeniSyndrome

@oncology.ox.ac.uk @oxfordcancer.bsky.social

The MILI site team based in Leicester Royal Infirmary speak on what this study means to them.

Find out more about MILI here: mili.octru.ox.ac.uk

#LFS #TP53 #LiFraumeniSyndrome

Members of the MILI Trial team are attending the 2025 CRUK Cancer Prevention Research Conference this week.

@cancerresearchuk.org @oxfordcancer.bsky.social
#CRUK #LFS

#InternationalNursesDay
#InternationalNursesDay2025

To all the research nurses working on the SCOOT trial.

Thank you for all that you do!

#InternationalNursesDay
#InternationalNursesDay2025

To all the research nurses working on the MILI trial!

@ouhospitals.bsky.social
@gstt-nhs.bsky.social
@cuh.nhs.uk
@nhsgrampian.bsky.social
@uhsft.bsky.social
@leicestersresearch.bsky.social
@nottmhospitals.bsky.social

#InternationalNursesDay
#LFS
#TP53

To all the research nurses working on the TebeMRD trial.

#InternationalNursesDay #InternationalNursesDay2025

On #InternationalNursesDay...

Thank you to all our recruiting sites for your support of the trial:

@ouhospitals.bsky.social
@gstt-nhs.bsky.social
@cuh.nhs.uk
@nhsgrampian.bsky.social
@uhsft.bsky.social
@leicestersresearch.bsky.social h.bsky.social

A MILI Milestone:

30 participants randomised onto the trial!

#TP53 #LiFraumeniSyndrome #LFS

@oncology.ox.ac.uk
@oxfordcancer.bsky.social
The George Pantziarka TP53 Trust

What is LFS? A person with LFS carries a pathogenetic variant in their TP53 gene associated with an increased risk of cancer. To find out more about LFS and current research, including the MILI clinical trial:
MILI tinyurl.com/nu3w4ba3
TP53 Trust tinyurl.com/yufxf4um
#LFS @oxfordcancer.bsky.social

The MILI trial is pleased to announce that our 7th site, University Hospitals of Leicester NHS Trust, is now open to recruitment!

#TP53 #LiFraumeniSyndrome #LFS

@leicestersresearch.bsky.social
@oxfordcancer.bsky.social
@oncology.ox.ac.uk

The MILI trial is pleased to announce that our 6th site, University Hospital Southampton NHS Foundation Trust, is now open to recruitment!

@uhsft.bsky.social
@oxfordcancer.bsky.social
@oncology.ox.ac.uk

#TP53 #LiFraumeniSyndrome #LFS

MILI Participants, we want to hear from you!

#TP53 #LiFraumeniSyndrome #LFS #OxfordCancer #rarediseases

@oxfordcancer.bsky.social @oncology.ox.ac.uk @ouhospitals.bsky.social @cuhnhs.bsky.social @nottmhospitals.bsky.social @nhsgrampian.bsky.social
@gstt-nhs.bsky.social

Why Is MILI Randomised? The MILI trial is designed to test whether metformin, a drug that treats type II diabetes, can reduce the risk of cancer in people with Li Fraumeni Syndrome (LFS). The truth is that we don’t know i…

....visit The George Pantziarka TP53 Trust article on randomisation in the MILI Trial to find out more:

tp53.co.uk/2024/08/13/w...

#LFS #TP53

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The full title of the MILI trial is "Metformin in Li Fraumeni Syndrome Trial: A phase II randomised open-label cancer prevention trial of metformin in adults with Li Fraumeni Syndrome".

But what does "randomised" mean, and why is it done...
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@oxfordcancer.bsky.social
@oncology.ox.ac.uk

#WorldCancerDay #UnitedByUnique

@oncology.ox.ac.uk @oxfordcancer.bsky.social @octructu.bsky.social

#WorldCancerDay #UnitedByUnique

TebeMRD Trial website: tebemrd.octru.ox.ac.uk

#WorldCancerDay #UnitedByUnique

@oncology.ox.ac.uk @oxfordcancer.bsky.social

SCOOT is a study aiming to use blood biomarkers to help diagnose lung cancer more accurately and quickly than we can now.

Find out more about SCOOT here:

tinyurl.com/SCOOT-OCTO

#worldcancerday #unitedbyunique #earlydetection

@oncology.ox.ac.uk @oxfordcancer.bsky.social @octructu.bsky.social

#WorldCancerDay #UnitedByUnique

@oncology.ox.ac.uk @oxfordcancer.bsky.social

To learn more about MILI and Li Fraumeni Syndrome, visit:

mili.octru.ox.ac.uk

and

LFS / TP53 – The George Pantziarka TP53 Trust: tp53.co.uk/lfs-tp53/

#LFS #WorldCancerDay #unitedbyunique

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The MILI trial will help to understand:

· How cancers form in Li Fraumeni Syndrome (LFS)
· How metformin affects this
· The impact of having LFS on quality of life

#WorldCancerDay #UnitedByUnique #LFS

@oncology.ox.ac.uk @oxfordcancer.bsky.social

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Pink square graphic with black text which reads, 'World Cancer Day - 4 February'

In the UK, nearly 1 in 2 people will get cancer in their lifetime. It's World Cancer Day today – a global day to raise awareness and take action against cancer 🌍

Whatever your cancer experience, share this post and help us get the word out.

#WorldCancerDay #WCD2025

Cancer | NIHR Oxford Biomedical Research Centre NIHR Oxford Biomedical Research Centre

On #WorldCancerDay, we're advancing early detection by studying biomarkers to identify high-risk individuals. We're also exploring immunotherapies to stop cancer early—potentially changing its course https://buff.ly/40ZXoIm

#CancerResearch #EarlyDetection

Patient & Public Involvement (PPI)

Research is stronger when shaped by the voices of those affected by cancer. 🌱

Patient & Public Involvement empowers individuals to contribute to research, ensuring that our researchers, and their studies, benefit from the perspectives of people affected by cancer

Find out more: buff.ly/40Mmd90

#WorldCancerDay is putting a spotlight on the unique needs of everyone impacted by cancer.

People-centred care is crucial for equity, quality & efficiency, and means putting the comprehensive needs of people and communities, not only diseases, at the centre of health systems.

#UnitedByUnique