NIHR Oxford BRC

Follow us to find out more about antimicrobial resistance this World Antimicrobial Awareness Week!

#WAAW #WAAW2025 #AMR @oxfordbrc.bsky.social

Great to see this investment in early-phase trials in Oxford, which will benefit our Inflammation Across Tissues theme - and ultimately patients with inflammatory conditions.
@ouhospitals.bsky.social @nihr.bsky.social @ndorms.bsky.social @kiroxford.bsky.social

Subpopulations in clinical samples of M. tuberculosis can give rise to rifampicin resistance and shed light on how resistance is acquired AbstractObjectives. WGS has become a key tool for diagnosing Mycobacterium tuberculosis infections, but discrepancies between genotypic and phenotypic drug

For #WorldAntimicrobialAwarenessWeek, we introduce our recent paper on antibiotic-resistant subpopulations in TB.
TB may be one of humanity’s oldest diseases, yet it still kills over 1M people yearly. As resistance spreads, knowing each patient’s resistance profile before treatment is vital. 🧬💊

Antimicrobial resistance occurs when bacteria, viruses, fungi & parasites change over time - leading to medicines being less effective against them.
Here you see bacteria growing and antibiotics (the small discs) which kill the bacteria...unless they are resistant!
#WAAW #AMR @oxfordbrc.bsky.social

Oxford scientists map the cells that drive Crohn’s disease fistulas, Scientists at the University of Oxford, have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that develop in around 30%

NEW: Oxford scientists have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that develop in around 30% of people with Crohn’s disease.

Crohn’s disease affects around 1 in every 650 people.

Study reveals how drug resistance develops early in targeted AML therapy A new study led by researchers at the MRC Molecular Haematology Unit has shown that resistance to a targeted treatment for acute myeloid leukaemia (AML) can develop much earlier than expected.

NEW: Researchers in the Vyas Group used TARGET-seq+ to uncover how drug resistance develops in new treatment for acute myeloid leukaemia - these findings could help identify patients likely to relapse & find ways to prevent or treat relapse 🧪

Learn more 👇

@rdm.ox.ac.uk @oxfordbrc.bsky.social

Our November #newsletter is out now!

Features include:
🧠 #antidepressant – and how they affect the body
🎨 Whatwecarry – a collaborative art-science project around #chronicpain
♿ #DisabilityHistoryMonth

Catch up on all the latest from our BRC and partners:
tinyurl.com/NovOHBRCnews...

At-home test could play key role in type-1 diabetes screening | NIHR Oxford Biomedical Research Centre

Our researchers are trialling a new home test to diagnose type 1 diabetes #T1D in children and young people to see if could work in the NHS oxfordbrc.nihr.ac.uk/at-home-test... #WorldDiabetesDay @ouhospitals.bsky.social @nihr.bsky.social @ndm.ox.ac.uk

This looks a really interesting talk - especially for those working in women's health, health equity or public engagement
@ouhospitals.bsky.social @oxfordwomenshealth.bsky.social @medsci.ox.ac.uk

National registry launched to transform care for people at risk of type 1 diabetes | NIHR Oxford Biomedical Research Centre

It’s #WorldDiabetesDay, a great opportunity to recall the recently created national registry that could transform care for people at risk of type 1 diabetes #T1D #diabetes oxfordbrc.nihr.ac.uk/national-reg... @ouhospitals.bsky.social @nihr.bsky.social @ndm.ox.ac.uk

Oxford scientists map the cells that drive Crohn’s disease fistulas Researchers at the MRC Translational Immune Discovery Unit have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that dev...

#WIMMReads: New @nature.com study, led by the Simmons & Antanaviciute Groups, used advanced single-cell and spatial analysis techniques to map the cells that drive #Crohn's fistulas - paving the way for targeted treatments 🧪

Learn more 👇

@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk

Scientists map cells that drive Crohn’s disease fistulas, paving way for targeted treatments | NIHR Oxford Biomedical Research Centre

Scientists at @imm.ox.ac.uk have identified how rare populations of abnormal cells drive the formation and persistence of fistulas in some people with #CrohnsDisease oxfordbrc.nihr.ac.uk/scientists-m... @ouhospitals.bsky.social @medsci.ox.ac.uk @rdm.ox.ac.uk @nihr.bsky.social

Bash The Bug (@BashTheBug) / X Bash The Bug (@BashTheBug) / X

Are you interested in infections, the micro-organisms that cause them and antimicrobial resistance? So are @bashthebug.net and they're looking for new members to join their patient & public group. More info: bashthebug.net/lay-represen... Deadline 27 Nov @ouhospitals.bsky.social @medsci.ox.ac.uk

YouTube video by Oxford BRC Why are more younger people having strokes? Linxin Li

Our brilliant Clinical Research Fellow in #Neurosciences, Linxin Li, gave a fascinating talk this week on the worrying trend of rising #strokes in adults under 55 and the key risk factors?

Watch the full talk here: youtu.be/gjiaU5ztHq8?...

@ox.ac.uk @ouhospitals.bsky.social #preventativeneurology

YouTube video by MRC Weatherall Institute of Molecular Medicine Oxford scientists capture genome’s structure in unprecedented detail

@ox.ac.uk story www.rdm.ox.ac.uk/news/oxford-...

Explainer video: youtu.be/EsI5r5fitx0

@imm.ox.ac.uk @wellcometrust.bsky.social @oxfordbrc.bsky.social

Join us this evening for a FREE public talk with the brilliant Linxin Li, #Clinical #Research Fellow in #Neurosciences at #Oxford University, to explore why more younger people are having strokes and is there a solution?
@ox.ac.uk @ouhospitals.bsky.social @medsci.ox.ac.uk
Refreshments 5:40pm.

This trial led by Professor Clare Verrill gives hope for more accurate and speedier diagnosis of #ProstateCancer. Great that @ouhospitals.bsky.social is one of the three NHS trusts taking part
@ndsurgicalsci.bsky.social @medsci.ox.ac.uk @prostatecanceruk.bsky.social
www.ouh.nhs.uk/news/article...

Radio Oxford - Listen Live - BBC Sounds Listen live to Radio Oxford on BBC Sounds

Clinical Research Fellow in Neuroscience, Linxin Li interviewed on BBC RADIO OXFORD below with key insights on her Free Public Talk ‘Why are more younger people having strokes?
Listen in: Adam Ball Show at 10:13.
Come along tomorrow 6pm, Rewley House, Oxford, OX1 2JA.
www.bbc.co.uk/sounds/play/...

Can AI tools improve clinician decision-making in emergency departments?

OUH and @radiobotics.bsky.social have launched the UK’s first RCT of AI-assisted fracture detection.

More details on: www.ouh.nhs.uk/news/article...

@sbrihealthcare.bsky.social @healthinnovox.bsky.social

Free Public Talk in Oxford at 6pm on 4th November. Lecture Theatre, Rewley House. Linxin Li, Clinical Research Fellow in Neurosciences will explore why more younger adults are having strokes and is it preventable? Join us on Tuesday.

Meet Linxin Li, our brilliant Clinical Research Fellow at Oxford Uni. who is delivering the Free Public Talk in Oxford on Tuesday. She’s won 7 research awards over the last ten years.

🔎Read her profile: www.ndcn.ox.ac.uk/team/linxin-li
#stroke #disease #healthcare #communityimpact
@ox.ac.uk

Really good to see these findings.
The BRC is very proud to have supported this research.
@ouhospitals.bsky.social @nihr.bsky.social

Information about a Free Public Talk in Oxford on 4th November at 6pm which will explore recent Stroke data and asks 'Why are more younger people having strokes?. This will be delivered by the brilliant Linxin Li, Clinical Research Fellow at Oxford University's Nuffield Department for Neurosciences. The public talk will be at the Lecture Theatre, Rewley House, Oxford.

Recent stroke data indicates a worrying trend. Join our Free Public Talk in #Oxford next week as we ask 'Why are more younger people having strokes?'
🔎 Read more: lnkd.in/eQUcwCcY

#StrokeActionNow #ActFAST #WorldStrokeDay #StrokeAwareness #EveryMinuteCounts

@ox.ac.uk @ouhospitals.bsky.social

Date for your diary! 💡FREE Public Talk - 4th Nov – #Oxford
Why is there a recent increase in #Strokes among adults in their 20’s, 30’s and 40’s. This means a higher risk of #disability. Is this #preventable?
🔎 Read more: oxfordbrc.nihr.ac.uk/brc-event/fr...
@ox.ac.uk @oxfordnewstoday.bsky.social

Almost 70% of bowel cancers missed at colonoscopy are avoidable | NIHR Oxford Biomedical Research Centre

A major nationwide #research study has revealed almost 70% of Bowel #Cancers missed at colonoscopy are avoidable.

🔎Read the findings: oxfordbrc.nihr.ac.uk/almost-70-of...

Funded by
@bowelcanceruk.bsky.social
@cancerresearchuk.org
Health Data Research UK
@nihr.bsky.social
Oxford BRC.
@ox.ac.uk

World’s largest hip fracture research platform launched to improve care and outcomes | NIHR Oxford Biomedical Research Centre

World’s largest #HipFracture research platform - based @ndorms.bsky.social launched to improve care and outcomes for patients oxfordbrc.nihr.ac.uk/worlds-large... @ouhospitals.bsky.social @nihr.bsky.social @medsci.ox.ac.uk

Elderly people exercising

An NDORMS study has found that a tailored exercise programme for people aged 80 years + with osteoarthritis is practical and acceptable, leading the way to a large clinical trial. https://www.ndorms.ox.ac.uk/news/study-finds-tailored-exercise-programme-feasible-for-adults-over-80-with-osteoarthritis

Great to see this interview with @danlasserson.bsky.social from our Digital Health from Hospital to Home theme about the benefits of delivering acute care in community settings @nihr.bsky.social @ouhospitals.bsky.social @uhcw-nhs.bsky.social @randd-uhcw.bsky.social @uni-of-warwick.bsky.social

New paper: What can subpopulations tell us about rifampicin resistance? Last Thursday this work which we'd previously preprinted looking at looking at rifampicin-resistant subpopulations in clinical M. tuberculosis samples was published in JAC-Antimicrobial Resistance. If...

New paper by @vbrunner.bsky.social looking at detecting rifampicin resistant subpopulations in M. tuberculosis infections using genetics and putting a lower limit on the proportion that arose due to secondary infections.

bit.ly/47rwf42

@modmedmicro.bsky.social
@oxfordbrc.bsky.social

Black History Month at Oxford | University of Oxford Oxford University is delivering another programme of events for Black History Month throughout October.

Throughout October, Oxford will host events celebrating #BlackHistoryMonth – recognising the impact of Black heritage and culture on Britain, the world, and our University.

More info ⬇️ #BHM
https://www.ox.ac.uk/news-and-events/black-history-month

Our October newsletter is out!
Highlights:
🧠 #Neurodiversity Conference success
🌍 #WorldMentalHealth Day reflections
🏛️ New Research Inclusion Hub launch
Catch up here 👉 tinyurl.com/OHBRCissue20