Laura Marsh

How is the body experienced in mental health conditions? 🧠🫀🫁

Our (@gabmackie.bsky.social) new paper in eClinicalMedicine explores lived experiences and patient priorities for interoception research. 🧵1/n

www.sciencedirect.com/science/arti...

🆕Study Alert! King’s College London: Transdiagnostic Dissociative Symptoms

🔗 www.unrealcharity.com/kings-transd...

✉️ TRIAD@kcl.ac.uk or contact @susannahpick.bsky.social

#DepersonalisationDerealisationDisorder #DPDR #Depersonalisation #Derealisation #MentalHealthResearch

Interested in a Cambridge PhD? Apply for AIM to get ready!
@camneuro.bsky.social @tamsinford.bsky.social @gkmurray.bsky.social
www.postgraduate.study.cam.ac.uk/aim-phd

Outcome measurement in functional neurological disorder: A qualitative study on the views of patients, caregivers and healthcare professionals - Journal of Neurology Background In this qualitative study, we aimed to obtain and synthesise the views of patients with functional neurological disorder (FND), their caregivers, and relevant healthcare professionals (HCPs...

Sharing our new paper reporting key stakeholder perspectives on outcome measurement in #FND. This work will help ensure that outcome measures are patient-centred and clinically relevant in future. Thanks Sonja Rutten @abw89.bsky.social @timnicholson.bsky.social! 🙏 link.springer.com/article/10.1...

I am delighted this work by @gerardosalvato.bsky.social et al on the relationship between disturbances in the sense of body ownership & temperature regulation is finally published! doi.org/10.1038/s414... Here is a thread on the long, scientific whodunit 1/11

Emotional State Transitions in Trauma-Exposed Individuals With and Without PTSD This cross-sectional study examines whether trauma-exposed individuals with posttraumatic stress disorder have a sharper transition between neutral and negative emotional states compared with trauma-e...

Interesting study on transitions between emotional states in individuals with PTSD and healthy controls:

Are you based in London? We are recruiting participants for our study. We need to test 400 people so would appreciate sharing. Thank you!

With many thanks to the study participants, and the original study authors for generously sharing their data!

These results provide evidence for an inhibitory control mechanism operating to prevent the recognition of personally-relevant stimuli in dissociative amnesia.

By contrast, the inhibitory activation pattern persisted in the second participant, who did not show any memory recovery following this treatment.

Following treatment (interview under sedation), one participant recovered almost all of his memories. On repeating the task, he no longer showed activation of the retrieval inhibition network when reminded of current colleagues.

Critically, effective connectivity analyses provided evidence that the hippocampus was actively downregulated by the right anterior DLPFC when patients failed to recognise their current colleagues.

Reduced activation was observed across autobiographical memory regions including in the mPFC and the anterior hippocampus, demonstrating further functional alignment with the regions downregulated during retrieval stopping in the Think/No Think task.

When the participants were reminded of people from forgotten time-periods (their current colleagues), they engaged a network of regions very similar to those engaged when during laboratory-based retrieval inhibition tasks (mega-analysis of the Think/No-Think task).

Participant 1 experienced a 2-day fugue episode, following which he remained amnesic for the ~4.5 years preceding onset.
Participant 2 presented with a focal retrograde amnesia for the past 35 years of his life.

We re-analysed fMRI data from two people with generalised dissociative amnesia to test the theory that memory retrieval is inhibited via prefrontal control.

Generalised forms of dissociative amnesia involve memory loss for extended periods of the personal past, often several years or decades, in the absence of identifiable neuropathology. The underlying neurobiological mechanisms are poorly understood.

Happy to share our new paper on the inhibition of memory retrieval in dissociative amnesia, with @dcdace.bsky.social, Hirokazu Kikuchi, Nobuhito Abe &, Jun Kawaguchi, Mike Kopelman & @memorycontrol.bsky.social
doi.org/10.1017/S003...

Delusional Unreality and Predictive Processing Phenomenological psychopathologists have recently highlighted how people with delusions experience multiple realities (delusional and non-delusional) and have suggested this double bookkeeping cannot be explained via predictive processing. Here, we present data from Kamin blocking and extinction learning that show how predictive processing might, in principle, explain a pervasive sense of dual reality.

New from us:

People with delusions sometimes feel that the world is unreal.

Here, we explain this in terms of prediction errors, with Kamin blocking behavioral and computational data from patients, psychics, and controls

www.biologicalpsychiatrycnni.org/article/S245...

I've put together a starter pack for the FND science community.

Please repost to share the link and do let me know of any folks I've missed so I can add them to the group.

Functional Neurological Disorder: Neuropsychological and psychological management in children and adults | BPS - British Psychological Society BPS Explore is our easy-to-access central location for you to read and download a wide range of psychological content from practitioners, researchers and working groups.

🚨 THE PSYCHOLOGICAL MANAGEMENT OF FND IN CHILDREN AND ADULTS 🚨

A new briefing paper from the Division of Neuropsychology @donbps.bsky.social

Proud to be part of the team working on this chaired by @nielsdetert.bsky.social & dedicated to the late Jason Price who originally conceived of the idea 🙏❤️

By popular demand, I have begun making a cognitive neuroscience starter pack. If you scan brains, you can be on it! go.bsky.app/2n84SRM