Lung ultrasonography for community-acquired acute pneumonia diagnosis Over the past two decades, several studies have assessed the performance of lung ultrasonography in the diagnosis of community-acquired acute pneumoni…

[Publication] The article "Lung ultrasonography for community-acquired acute pneumonia diagnosis" is now available.

www.sciencedirect.com/science/arti...

#IDsky #CommunityAcquiredAcutePneumonia #LungUltrasonography #ChestXRay #ChestCTScan

Value of molecular biology tests in community-acquired acute pneumonia For patients hospitalized with community-acquired acute pneumonia (CAP), molecular tools (especially multiplex PCR syndromic panels) are associated wi…

[Publication] The article "Value of molecular biology tests in community-acquired acute pneumonia" is now available.

www.sciencedirect.com/science/arti...

#IDsky #CommunityAcquiredAcutepneumonia #MolecularBiology #MultiplexPCR #SyndromicPanel

Indications for corticosteroids in the treatment of Community-Acquired pneumonia Preceding guidelines on treatment and management of community-acquired pneumonia (CAP) do not endorse systematic use of corticosteroids. The data in t…

[Publication] The article "Indications for corticosteroids in the treatment of Community-Acquired pneumonia" is now available.

www.sciencedirect.com/science/arti...

#IDsky #CommunityAcquiredPneumonia #Corticosteroids #Mortality

Duration of antibiotic treatment for community-acquired pneumonia Previous guidelines have recommended 5-day antibiotic treatment for community-acquired pneumonia (CAP) patients manifesting clinical improvement after…

[Publication] The article "Duration of antibiotic treatment for community-acquired pneumonia" is now available.

www.sciencedirect.com/science/arti...

#IDsky #CommunityAcquiredPneumonia #Antibiotics #Mortality #TreatmentDuration

Antibiotic combination indications for the treatment of community-acquired acute pneumonia Empirical dual combination therapy with beta-lactam and macrolide is often the standard treatment of community-acquired acute pneumonia (CAP) in adult…

[Publication] The article "Antibiotic combination indications for the treatment of community-acquired acute pneumonia" is now available.

www.sciencedirect.com/science/arti...

#IDsky #CommunityAcquiredAcutePneumonia #EmpiricalAntibioticTherapy #BetaLactam #Macrolide

Vancomycin Taper trial presented by @dremilymcd.bsky.social #ESCMID2025. In people who get better by day 10 should we stop or give taper? Reduced recurrences by primary outcome timepoint but the KM suggests it may be just delaying rather than truly preventing recurrence? #IDSky

Does adding NGS testing improve sepsis outcomes? Gave more positive micro. No impact primary outcome. Many secondary outcomes better but ?appropriate report p values if primary null. Clinicians didnt change Abx in response to NGS. Unclear if some analysis were pre-planned or post-hoc. #ESCMID2025

HARVEST Trial - largest trial high dose (35mg/kg) Rifampicin for TBM. Phase 2 data suggested benefit & dose-response effect. Sadly no evidence of benefit & some suggestion of sub-groups who did worse. More trials coming & clear we need interventions beyond just killing bug #ESCMID2025 #IDSky

Actualisation des recommandations de prise en charge des pneumonies aiguës communautaires chez l'adulte par la Société de Pathologie Infectieuse de Langue Française (SPILF) et la Société de Pneumologi... La Pneumonie Aiguë Communautaire (PAC) présumée d'origine bactérienne est une pathologie fréquente plus ou moins grave qui peut être prise en charge e…

French CAP guidelines @spilf.bsky.social @soc-pneumo-splf.bsky.social
www.sciencedirect.com/science/arti...

Early oral stepdown therapy for infective endocarditis: an international cross-sectional survey on current use in clinical practice There is now strong evidence supporting early oral switch (EOS) from intravenous antibiotics in the treatment of infective endocarditis (IE). Our obje…

🆕💫 Early oral stepdown therapy for infective endocarditis: an international cross-sectional survey on current use in clinical practice ESCMID Study Group for Bloodstream Infections, Endocarditis and Sepsis
#idsky #IEWiki
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...

IDSA: Uncomplicated UTI can occur in females or males, patients with underlying urologic abnormalities, patients with immunocompromise, and persons with diabetes. Recurrent UTI can be uncomplicated.
Male + cystitis # cUTI
Immunocompromised or DM + cystitis # cUTI #IDsky #utisky #medsky #EMIMCC

19,764 S. aureus isolates were collected from patients with various infection types at 37 US medical centers 2016 to 2022
MRSA (8,184) isolates:
Bactrim: 95% S
Clindamycin: 74% S
Vancomycin: 100% S
MDR MRSA (2,421) isolates:
Bactrim: 85% S
Clindamycin: 17% S
Vancomycin: 100% S #idsky

The world may look back on 2024 as a pivotal time in the fight against AIDS — There is still no cure and no preventive vaccine for HIV. But long-acting antiretrovirals(ARVs )are the closest thing to a vaccine that the world has today #IDsky #hivsky
www.nejm.org/doi/full/10....

Dynamic characteristics of high-risk HPV infection in women with low-grade cervical intraepithelial neoplasia, based on a community longitudinal study - European Journal of Clinical Microbiology & Inf... Background High-risk human papillomavirus (HR-HPV) infection is the primary cause of cervical cancer and precancerous lesions. Approximately 35% of women with low-grade cervical intraepithelial neopla...

High-risk human papillomavirus infection is the primary cause of cervical cancer & precancerous lesions
🆕💫Dynamic characteristics of high-risk HPV infection in women with low-grade cervical intraepithelial neoplasia, based on a community longitudinal study #idsky
link.springer.com/article/10.1...

New study in @cidjournal.bsky.social from France looking at molds (no yeast/dimorphics) found in blood cultures.

n=80 isolates from 2012-2022

2/3rds were Fusarium, 10% Lomentospora, 5% Trichoderma, 5% Mucorales, 5% Aspergillus

70% Hematologic malignancies

academic.oup.com/cid/advance-...

In the context of emergence of cefiderocol resistance& limited therapeutic options,in vitro determination of cefiderocol susceptibility w a robust method is essential!
🆕💫Cefiderocol susceptibility testing:the challenge of disc diffusion #idsky
www.clinicalmicrobiologyandinfection.com/article/S119...

Cervical Cancer | NEJM Accounting for approximately 350,000 deaths annually worldwide, cervical cancer is preventable with HPV vaccination and screening. Newer chemotherapy, radiotherapy, and immunotherapy techniques hav...

Accounting for approximately 350,000 deaths annually worldwide, cervical cancer is preventable with HPV vaccination and screening. Newer chemotherapy, radiotherapy, and immunotherapy techniques have improved survival #idsky #medsky
www.nejm.org/doi/full/10....

Bone Voyage: Navigating Updates in the Management of Bone and Joint Infections - Current Infectious Disease Reports Purpose of Review Advancements in the management of bone and joint infections (BJIs) aim to improve outcomes while challenging long-standing treatment practices. This review discusses key updates, inc...

Recent studies reinforce the benefits of oral antibiotics, as well as shorter durations of therapy in BJIs with supporting evidence
🆕💫 Review article
Bone Voyage: Navigating Updates in the Management of Bone and Joint Infections #idsky
link.springer.com/article/10.1...

Infectious complications following transperineal prostate biopsy with or without periprocedural antibiotic prophylaxis—a systematic review including meta-analysis of all comparative studies - Prostate... Prostate Cancer and Prostatic Diseases - Infectious complications following transperineal prostate biopsy with or without periprocedural antibiotic prophylaxis—a systematic review including...

🆕💫 Systematic review including meta-analysis of all comparative studies
Infectious complications following transperineal prostate biopsy with or without periprocedural antibiotic prophylaxis #idsky
www.nature.com/articles/s41...

🆕🔥Just published 🔥🆕
Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis(TB)
An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline #idsky #TBsky
www.atsjournals.org/doi/full/10....

Temocillin efficacy against AmpC β-lactamase-producing Enterobacterales: a relevant alternative to cefepime? AbstractIntroduction. Temocillin is a semi-synthetic β-lactam with a narrow spectrum but high stability against hydrolysis by β-lactamases, including AmpC.

🆕💫 Retrospective multicentre
study #JAC
Temocillin efficacy against AmpC β-lactamase-producing Enterobacterales: a relevant alternative to cefepime? #idsky #medsky #EMIMCC #utisky
academic.oup.com/jac/advance-...

Treating Patients, Not P Values To the dismay of many statisticians, clinicians are taught to convert continuous results into a binary value to facilitate decision-making. A person with a hemoglobin A1c level of 6.5% or higher ha...

Neither 95% confidence intervals nor P values are meant to be signposts for clinical decision-making
The curious case of 2 negative trials in TB (VQUIN + TB-CHAMP) #idsky #medsky #EMIMCC #TBsky
evidence.nejm.org/doi/full/10....

β-Lactam Inoculum Effect in Methicillin-Susceptible S aureus Infective Endocarditis This case series evaluates the association between phenotypic characteristics of Staphylococcus aureus isolates, β-lactam used, and outcome in patients with methicillin-susceptible S aureus (MSSA) inf...

🆕🔥Case series
First-month mortality in MSSA left-sided IE strains appeared to be independently associated with the presence of blaZ and an inoculum effect, and this may account for some differences in outcomes between ASP & Cefazolin #idsky #EMIMCC
jamanetwork.com/journals/jam...

Time to Staphylococcus aureus blood culture positivity is a useful marker for infective endocarditis

This retrospective cohort study of >1700 cases of SAB suggests that if TTP > 13 hrs, the patient is unlikely to have endocarditis (NPV 96%, 95%CI 95-97)

academic.oup.com/cid/advance-... #IDSky

Unlike CRE, in which the molecular resistance mechanism (genotype) usually predicts the susceptibility pattern (phenotype), the genotype-phenotype correspondence is not true for CRPA #idsky #EMIMCC

Effectiveness of ceftazidime–avibactam versus ceftolozane–tazobactam for multidrug-resistant Pseudomonas aeruginosa infections in the USA (CACTUS): a multicentre, retrospective, observational study Treatment with ceftolozane–tazobactam resulted in higher rates of clinical success compared with ceftazidime–avibactam for invasive infections due to multidrug-resistant P aeruginosa. Differences were driven by improved response rates for patients with pneumonia who were treated with ceftolozane–tazobactam. There were no significant differences between study groups with respect to all-cause mortality; treatment-emergent resistance was common with both agents.

🔥🆕️CACTUS
Multi center real world data on ceftaz/avi vs ceftol/tazo for MDR PsA bacteremia or pneumonia
Overall similar clinical success including mortality, recurrent infection & resistance #idsky #EMIMCC #medsky
www.thelancet.com/journals/lan...

4 weeks! 🤯

Real-world multicentre study of cefiderocol treatment of immunocompromised patients with infections caused by multidrug-resistant Gram-negative bacteria: CEFI-ID The increase in the population of immunocompromised patients due to advances in management of end-stage diseases and transplants poses challenges in treating infections caused by multi-drug resistant (MDR) pathogens. Cefiderocol (FDC), a siderophore cephalosporin, has shown efficacy against carbapenem-resistant Gram-negative bacteria.

CEFI-ID
🆕✨Real-world multicentre study of cefiderocol treatment of immunocompromised patients with infections caused by multidrug-resistant Gram-negative bacteria #idsky
www.journalofinfection.com/article/S016...

Great list @absteward.bsky.social! Mine is coming soon (limited to 10)