Jacky Goetz

That is nice 🤩 congrats

Inflammation during viral infection can rouse dormant cancer cells Sometimes, cancer cells that have spread become ‘dormant’ but can start proliferating again later. A cue that can reactivate them has been discovered.

👉 News & views :
www.nature.com/articles/d41...
👉 News : Nature Portfolio
www.nature.com/articles/d41...

Experimental models of hashtag#metastatic dormancy reveals that some viruses (i.e. influenza & SARS-CoV-2 #COVID) can reactivate cancer cells
👉 The original study @nature.com :
www.nature.com/articles/s41...
👉 French news (with some of my comments) Le Figaro :
sante.lefigaro.fr/medecine/la-...

💰 Supported by many, but mostly by La Ligue contre le Cancer & Institut national du cancer & @inserm.fr & @unistra.fr

👨‍🎓 Another opus of a wonderful collaboration spearheaded by Emily Janus-Bell & Cristina Liboni (in my lab) and with strong support from many (in my team Vincent Mittelheisser Louis Bochler Vincent Hyenne O.Lefebvre & Maria J. García-León when she was in the lab).

Depletion of all platelet integrins impacts hemostasis, thrombosis and tumor metastasis A mouse strain depleted of all five platelet integrins confirmed their central role in the adhesive function of platelets, in hemostasis and thrombosis, and highlights their contribution to tumor grow...

💡 Check it out, it is already out @cp-iscience.bsky.social @cellpress.bsky.social
www.cell.com/iscience/ful...

❓ What makes #platelets sticky ?
👉 Integrins (among others) !
❓Can we generate a mouse model with NO integrins on #platelets ?
👉 Our collaborators #umr1255 #EFS had, and it is unique !❓What is the impact on #hemostasis, #thrombosis & #metastasis
👉 Massive in some instances, significant in others !

Dream job 🤩⬇️

#GRC_Angiogenesis2025 is about to begin and we want to thank our amazing sponsors for helping us support the young generation of vascular biologists!! See you all soon in Newport!!! @evborg.bsky.social @navbo.bsky.social @biologists.bsky.social @weizmanninstitute.bsky.social @yalecvrc.bsky.social

#sport & #science, next episode
You feel sick, tired & down,
but convinced that you still have some energy to do this.
Our body & mind have resources
that exceed our own expectations.

What : #Triathlon #4 in #2025
Format : Olympic (M)
Where : #Elsassmann
Rank: 15th (scratch),🥈 (M2M)

📸 P.Wihmet

Looking forward to joining this #Gordon in #Newport and dive back into this exciting #Vascular #Biology field (and see many friendly faces)

Thanks @karinayaniv.bsky.social & A.Eichmann for the invitation

😱 When you realize that your #ESTA isn't valid anymore...the night before flying out... 🤞

Vous souhaitez voter pour cette image ? C'est par ici : pollunit.com/en/polls/pri...

🙏

Have a look at this image from the lab, taken by @katkajerabkova.bsky.social, and vote for it as it is competing for the Grand Public Prize of the @sbcf.bsky.social

© Katerina Jerabkova-Roda (microscope de la plateforme PICSTRA du CRBS)

Cette très jolie image, réalisée par une équipe Inserm dirigée par Jacky Goetz, est en compétition dans la catégorie Grand Public pour l’élection de l’image de l’année 2025, organisée par @sbcf.bsky.social

💥 Very happy to share the latest publication of my friend Frederic Saltel 🤩 , where we helped them (a long time ago) going further into the biology of #invadosomes

febs.onlinelibrary.wiley.com/doi/epdf/10....

💥 Paper accepted (in principle) #cellfie 🤩
A long wait, a beautiful project, some amazing collaborations.
Stay tuned for more !
ALT : how cells (and cell-like beads) are deformed in constraining vessels

🤗

Our latest review !

@sbcf.bsky.social quelle est la date limite pour voter ?

👨‍🎓 Wonderful work lead by @vmittelheisser.bsky.social & Cristina Liboni (and Olivier Lefebvre) in my team, with another very tight collaboration with Silvia Maria Grazia Trivigno and Pierre Mangin UMRS 1255 EFS

And stay tuned as our latest study on that topic just got accepted for publication.

💡 In brief (highlights) :
- Platelets engage in an intricate crosstalk within the tumor microenvironment.
- Platelets compromise the antitumor immune response.
- Antiplatelet agents remain promising for cancer therapy.
- Platelets could be new weapons for tumor drug delivery.

💥 Check out our latest review article just out @cp-trendscancer.bsky.social @cellpress.bsky.social

doi.org/10.1016/j.tr...

In this paper, we carefully review multiple aspects that tightly link #platelets to #metastasis

Slide scanner, 20x objective
#PIC-STRA CRBS
@inserm.fr
@unistra.fr
#CRBS

This image is competing for the Société de Biologie Cellulaire de France (SBCF) 2025 image competition.

You like it ? Vote for it : pollunit.com/en/polls/pri...

#Skin biopsy, healthy patient, immunofluorescent staining: SOX10 (green), DAPI (red) and LAMP1 (blue).
In the image, SOX10 positive nuclei appear in yellow and lysosomes in blue/cyan.

“Beauty is skin deep”

While searching for #melanoma cells (which are SOX10 positive), @katkajerabkova.bsky.social in the lab was taken back by the peculiar pattern of hair follicle under the #microscope.

💰 Support and help ?
#Liguecontrelecancer
@inserm.fr
@unistra.fr
#CRBS
#PIC-STRACRBS
@fondationarc.bsky.social
@frm-officiel.bsky.social

👨‍🎓 Who ? This work has been performed and lead by @vmittelheisser.bsky.social as part of his Ph.D. work that A.Detappe and myself were lucky to supervise, with help from O.Lefebvre in my team. Warm Kudos to him.

🛏️ More details ? We discovered that PLGA NPs trigger a transcriptional priming toward activation in NK and pan T cells and improved NK cells anti-tumoral functions
But, Si-Gd NPs significantly impaired T cells activation as well as functional responses to a polyclonal antigenic stimulation.

💊 What ? We provide the first and hopefully very useful proteogenomic ressource for better selection of nanomaterials in the future.
Importantly, PLGA NPs show appealing potential for reactivating the immune system (of cancer patients).