@incicnrs

Using a prospectively registered methodology, we included and reviewed 99 articles that manipulated the enzymes or characterized DNA methylation at candidate genes, or more recently genome-wide, including in the context of in utero or developmental exposure to drugs.

The DNA methylation enzymatic machinery in substance use disorders: a systematic review Substance use disorders (SUD) are chronic affections defined by similar symptoms across a variety of psychoactive drugs, including alcohol, cocaine, opioids, or methamphetamine. Epigenetic mechanisms ...

If interested in epigenomics & substance use disorders, take a look at our systematic review. We summarize current knowledge on DNA methylation & related enzymes across rodent models & drugs of abuse. Written w/ PhD student Margot Diringer & post-doc Mathieu Bruggeman
www.biorxiv.org/content/10.1...

And don't hesitate to reach out if interested, in particular about mental health & neuroepigenetics. @incicnrs.bsky.social @agencerecherche.bsky.social
@cnrs.fr @cnrsbiologie.bsky.social @inserm.fr
@frm-officiel.bsky.social @fondationfyssen.bsky.social
@procrystal.bsky.social

Junior group leader position in Strasbourg NeuroStra aims to recruit outstanding junior scientists to develop projects aligned with the following themes: Mental health | Neuroepigenetics | Nociception and Pain

The Strasbourg (France) neuroscience community (NeuroStra) will offer 3 positions over the next 3 years for junior group leaders. Applicants should develop projects along 3 themes:
--> Mental health
--> Neuroepigenetics
--> Nociception and Pain
Spread the word!
neurostra.unistra.fr/actualites/a...

Sex-divergent brain epigenetic reprogramming by chronic opioids Opioid use disorder (OUD) is a chronic condition that exhibits sex differences in prevalence, symptoms and treatment. Yet, the epigenetic mechanisms underlying these differences remain largely unknown...

Overall, we uncover a profound epigenetic sex divergence that mediates convergent biological dysregulation, and highlight opportunities for developing improved therapeutic strategies tailored to sex-specific mechanisms.
www.biorxiv.org/content/10.1...

Happy to share our new preprint on opioid addiction! We profiled the multiomic consequences of chronic opioid exposure in male and female mouse brains, covering DNA methylation (using EMseq), 5 histone marks (Cut&Tag) & their transcriptional effects at bulk and cell-type-specific levels (vTRAP).

Drogues : des élus appellent le gouvernement à pérenniser les « salles de consommation à moindre risque » par une loi - Public Sénat Lors d’une conférence de presse au Sénat, plusieurs élus locaux et nationaux ont appelé l’Etat à se saisir de la question des Haltes Soins Addictions (HSA), ces salles de consommation et de soins pour...

Nous appelons à la pérennisation des Haltes Soins Addictions (#HSA), avec @alexandracordebard.bsky.social @michelerubirola.bsky.social et Alexandre Feltz.

À Paris et à Strasbourg, ces dispositifs essentiels de santé publique ont montré leur efficacité, confirmée par l'Inserm et l'IGAS.

Biomarqueurs en psychiatrie : quelle perspective ? Quels défis ? YouTube video by Bibliothèques de Marseille

Une belle conférence de Raoul Belzeaux pour en savoir plus sur les biomarqueurs en psychiatrie :
www.youtube.com/live/U23xWQv...

Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control study Informational gain from multiomic integration had already been documented in other medical fields. Our results pave the way toward similar advances in molecular psychiatry, and have practical implicat...

Happy to share our latest work. We analyzed 3 omic layers, DNA methylation, micro-RNAs & the transcriptome, in patients with major depressive disorder & controls. Results showed that the performance of MDD prediction increased with the number of layers considered. www.thelancet.com/journals/ebi...

A team effort with many friends & colleagues @cnrs.bsky.social @incicnrs.bsky.social @cnrsbiologie.bsky.social @ap-hp.bsky.social @unistra.fr @univ-amu.fr @upcite.bsky.social @douglasresearch.bsky.social @univ-spn.bsky.social

@cnrs.bsky.social @unistra.fr

@cnrs.bsky.social @unistra.fr

Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice - Nature Communications Depression is associated with dysregulated circadian rhythms. Here, the authors show a critical role for mPFC molecular clock in regulating depression-like behavior and therapeutic potential of clock ...

New work from Tsvetan Serchov & colleagues:
www.nature.com/articles/s41...

Frontiers | Behavioral and pharmacological characterization of planarian nociception IntroductionPain mostly arises because specialized cells called nociceptors detect harmful or potentially harmful stimuli. In lower animals with less convolu...

New work from Hervé Cadiou & colleagues:
www.frontiersin.org/journals/mol...