Ioannis Parodis

A flowchart depicting the management of lupus nephritis.

Kidney biopsy findings guide lupus nephritis management and treatment is tailored to inflammation severity and chronic damage, incorporating immunosuppressive and adjunctive measures to protect renal function.
https://www.nature.c...

An overview of the management of comorbidities and treatment adverse effects In lupus nephritis.

Comorbid conditions of lupus nephritis and adverse events associated with its treatment, for example infections, cardiovascular issues, and osteoporosis, require active management according to guidelines.
https://www.nature.c...

Our NEW Primer on Lupus nephritis is live today! By Parodis, Rovin, Tektonidou, Anders, Malvar, Mok & Mohan. Check it out here:

Get Primed on Lupus nephritis with our NEW PrimeView! FREE to download this week! https://www.nature.c... #medsky

A schematic that shows the activation pathways of adaptive immune cells in lupus nephritis and various possible therapeutic targets.

Adaptive immune cells in lupus nephritis are activated through various pathways, including via B cell and T cell receptors, and cytokine signalling, with multiple therapeutic targets identified for potential intervention.
https://www.nature.c...

An Illustration of the actions of calcineurin inhibitors in lymphocytes and podocytes.

Calcineurin inhibitors target shared signalling pathways in lymphocytes and podocytes, reducing cytokine and autoantibody production and preventing podocyte loss and glomerulosclerosis in lupus nephritis.
https://www.nature.c...

A diagram of how immune and non-immune factors contribute to proteinuria and chronic kidney disease progression in lupus nephritis.

Both immune and non-immune factors contribute to proteinuria in lupus nephritis, influenced by genetic, intrinsic, and extrinsic factors, leading to chronic kidney disease progression.
https://www.nature.c...

Novel IgG and IgA autoantibodies validated in two independent cohorts are associated with disease activity and determine organ manifestations in systemic lupus erythematosus: implications for anti-LIN... This study aimed to identify and validate novel autoantibodies that reflect global and organ-specific disease activity in systemic lupus erythematosus…

Happy to share our recent work:

www.sciencedirect.com/science/arti...

Still a lot we don’t know about #lupus

📍Estamos en Viena en #RheumaPreg25
Nuestra vicepresidenta trae la voz de pacientes al panel sobre los desafíos en la investigación en embarazo y lactancia con @lauraandreoli.bsky.social, Klara Rosta @rheproat.bsky.social, @karenschreiber.bsky.social Judit Sandor y @nelson-piercy.bsky.social

Delighted to share our review on #HealthDisparities in #rheumatology management in #JointBoneSpine.

Here, we discuss aspects such as social, societal & structural barriers to care and optimal management in #RMDs, & how we may tackle them.

🔗 www.sciencedirect.com/science/arti...

Lupus nephritis trials network (LNTN) repeat kidney biopsy-based definitions of treatment response: A systematic literature review-based proposal Within the frame of the Lupus Nephritis Trials Network (LNTN), we conducted a systematic literature review (SLR) to propose kidney tissue-based defini…

Tissue matters!

www.sciencedirect.com/science/arti...

#lupusnephritis #lupus #SLE #rheumatology

Genetic Testing in Biopsy-Confirmed Kidney Disease

AI for Education: Trends and Insights

"the shift from perception to cognition, the transition from generalized to personalized learning, and the rise of multimodal systems"

www.sciencedirect.com/science/arti...

Happy New Year! 🎆

Time is kidney!

Timely diagnosis of #lupusnephritis with a #kidneybiopsy and prompt initiation of immune and non-immune treatment to dampen inflammation and protect the kidney tissue is crucial.

#RheumSky #MedSky #lupus