Cluster of Excellence CMFI

Role of Formyl Peptide Receptor 2 and Toll-Like Receptor 2 in Skin Barrier Function and Atopic Dermatitis The skin acts as a barrier against external threats and plays an important role in tissue repair. Skin cells, including keratinocytes, sense microbe-a…

How do keratinocytes sense bacterial commensals or pathogens?
@cmfi.bsky.social
Here is our recent review:
www.sciencedirect.com/science/arti...

Studie: Nicht nur Antibiotika stören das Darm-Mikrobiom Studie unter Leitung der Universität Tübingen: Viele Nicht-Antibiotika schwächen die natürliche Schutzfunktion des Darms, sodass sich krankmachende Bakterien leichter dort ansiedeln können

#Antibiotika stören das #Mikrobiom im #Darm und ebnen so den Weg für Erkrankungen. Das gilt allerdings auch für viele Nicht-Antibiotika, zeigt eine neue Studie von @ghammeranne.bsky.social und @jdlcz.bsky.social ‪vom @lisamaierlab.bsky.social am @cmfi.bsky.social ‪der @unituebingen.bsky.social‬.

A new doctor is born 😊🥳
Welcome with me Dr. Haffner, the first PhD student of the group after wonderful years @cmfi.bsky.social

Michael published 8 articles & a review with 3 as 1st author..
www.science.org/doi/10.1126/...

www.pnas.org/doi/10.1073/...

Enhancing tandem mass spectrometry-based metabolite annotation with online chemical labeling - Nature Communications To improve annotation in non-targeted metabolomics studies, authors develop a Multiplexed Chemical Metabolomics (MCheM) platform, combining post-column derivatization with integrated data processing. ...

New paper from the group. Together with Chambers Hughes, Giovanni Vitale and our amazing collaborators, we developed a multiplexed chemical metabolomics workflow to assign functional groups in non-targeted LC-MS/MS data:

www.nature.com/articles/s41...

Behind the paper story:
go.nature.com/45ljV4d

Left: Compound-promoter interaction network. Fifty-three significant compound-promoter interactions are shown as edges in a Sankey diagram connecting the compounds (left, source nodes) to the promoters (right, target nodes). Edge thickness represents mean Z-scores (n = 8), while node size represents the total number of interactions. Right: Proposed model for the molecular mechanism of caffeine-ciprofloxacin antagonism. Caffeine triggers expression of MicF small RNA in a Rob-dependent manner, which then binds to the 5′-UTR of ompF mRNA to inhibit and decrease OmpF protein levels. This ultimately prevents ciprofloxacin from entering the cell, resulting in caffeine-ciprofloxacin antagonism

How are bacterial transport machineries regulated by external cues? @brochadolab.bsky.social &co identify environmental chemicals that regulate #transporter transcription, identifying the TF Rob as a key modulator of #EffluxPump expression in #Ecoli #AMR @plosbiology.org 🧪 plos.io/46pUM9Q

Study finds #caffeine can weaken effectiveness of certain #antibiotics

Substances from natural environment can trigger bacteria's alert systems – implications for future therapeutic approaches?

Read the press release here: www.cmfi.uni-tuebingen.de/en/news-even...

@unituebingen.bsky.social

It's finally out!🎉

We known that the #microbiome confers colonization resistance against #pathogens, we know that some meds 💊 affect gut microbes 🦠

So, do 💊 alter colonization resistance? It turns out that some do! If you wanna know more, check out our latest work www.nature.com/articles/s41...

Non-antibiotics disrupt colonization resistance against enteropathogens - Nature Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of such drugs.

Seeing this published is even better than eating sweets! I am so happy and proud of whole @lisamaierlab.bsky.social, especially Lisa and @jdlcz.bsky.social who walked the funny/exciting/rocky road with me until the very end. Check it out!
#science #microbiome #health

www.nature.com/articles/s41...

Unexpected side-effect: how common medications clear the way for pathogens

CMFI's @lisamaierlab.bsky.social @unituebingen.bsky.social show in @nature.com: many non-antibiotics weaken the natural protective function of the intestine.

Press release: www.cmfi.uni-tuebingen.de/en/news-even...

This is work of many years and many wonderful people! 🧑‍🔬

Led by Anne Grießhammer @ghammeranne.bsky.social and me at the Maier lab @lisamaierlab.bsky.social in Tübingen @cmfi.bsky.social. Read the TL;DR and how the project and Lisa's lab grew hand in hand here: go.nature.com/3Ix8lu3

🚨 Naming Challenge:
Help redefine the #glycopeptide family!

🏆Submit your idea & win 500 € + authorship credit

Let’s rethink antibiotic classification—together!

🧬 Deadline: Sept 15, 2025

👉 docs.google.com/forms/d/e/1F...

@nadineziemert.bsky.social #NameChallenge #NaturalProducts #Antibiotics

CMFI - Cluster of Excellence - Controlling Microbes to Fight Infections The CMFI is one of more than 50 Clusters of Excellence funded by the German federal and state governments as part of the Excellence Initiative. We develop new strategies to control microbial mechanism...

They are fundamental to how we understand, maintain, and restore health.

More about CMFI's microbiome researchers:
www.cmfi.uni-tuebingen.de/en/

#CMFI #Microbiome #MicrobesMatter #HumanHealth #MicrobiomeResearch #GutHealth #LifeScience #ScienceCommunication @apcmicrobiomeirel.bsky.social

𝗠𝗶𝗰𝗿𝗼𝗯𝗲𝘀: 𝗞𝗲𝘆 𝗽𝗹𝗮𝘆𝗲𝗿𝘀 𝗶𝗻 𝗵𝘂𝗺𝗮𝗻 𝗵𝗲𝗮𝗹𝘁𝗵

The human microbiome—comprising trillions of microorganisms—interacts closely with our immune, metabolic, and nervous systems. It influences directly our health.

On #WorldMicrobiomeDay, we celebrate the science that shows how much Microbes Matter.

The pill that might be relieving your heartburn but killing your gut microbes Why drugs commonly used against heartburn harm your gut microbiome

Big thanks to scientific writer Libera Lo Presti for this great little piece on our recent work exploring how proton pump inhibitors (PPIs) and pH affect human gut microbes.
Check it out here: go.nature.com/4lf6jNk

Die @unituebingen feiert Erfolg im Exzellencluster-Wettbewerb 🎉Freude und Jubel bei der Pressekonferenz zur Entscheidung der DFG am 22.05.25 mit gut 200 Gästen. Weitere Infos und Fotos gibt es online 👉 uni-tuebingen.de/universitaet... @cmfi.bsky.social @ml4science.bsky.social

Das Bild zeigt einen Brunnen vor der Neuen Aula. Darunter der Text: Sechs Exzellenzcluster werden in Tübingen gefördert.

Die Universität Tübingen erhält sechs #Exzellenzcluster, die im Rahmen der #Exzellenzstrategie vom 01.01.2026 an sieben Jahre lang gefördert werden! Darunter drei Cluster, die bereits etabliert sind und eine erneute Förderung erhalten. uni-tuebingen.de/universitaet... #ExStra #Forschung #UniTübingen

We were gathering together this evening to hear the announcement of the new clusters of excellence by the German research foundation. So happy to hear that @cmfi.bsky.social gets another round! Love the Team! #naturalproducts #fightinfections #secmet

Yeah! 7 more years for @cmfi.bsky.social
So many people to thank... We are a fantastic team!

🎉 Fantastic News 🎉

Our CMFI Cluster of Excellence @unituebingen.bsky.social receives funding extension for the next seven years.

Spokesperson Andreas Peschel @andreaspeschel.bsky.social: "We can now advance our research into resistance mechanisms and new antimicrobial agents!"

shorturl.at/rcK1A

After her excellent PhD defense, Maryam Mahmoudi goes on a ride with her supervisor Eric Kemen. Check out her work about temp variation in plant microbiota: doi.org/10.1093/isme... doi.org/10.1128/mbio...
More to come soon!
@zmbp-tuebingen.bsky.social
@cmfi.bsky.social
@unituebingen.bsky.social

Join us in Tubingen as a Junior Research Group Leader if you do research on #ESKAPE pathogens and infections and are interested in the highly cooperative environment of @dzif.bsky.social‬ and @cmfi.bsky.social ! Please send your application or forward to colleagues!
uni-tuebingen.de/universitaet...

I am happy to share our latest preprint, spearheaded by Laura Camus. We show that tyrosin-dependent interactions can foster integration of S. aureus into the nasal microbiome. @cmfi.bsky.social @lmumuenchen.bsky.social
www.biorxiv.org/content/10.1...

Here are our ideas on developing tools and technologies for anaerobic bacteria! We hope you enjoy the read as much as we enjoyed brainstorming on the topic...

Spotify open.spotify.com/show/28niz6p...

Apple Podcasts podcasts.apple.com/us/podcast/i...

Audible www.audible.de/podcast/Insi...

Amazon Music music.amazon.com/podcasts/75b...

YouTube www.youtube.com/playlist?lis...

Podbean insidecmfi.podbean.com

@unituebingen.bsky.social

@dfg.de

Folge 4: Das Malignom und das Mikrobiom Inside CMFI: Potenziale der Mikrobiomforschung · Episode

#Podcast Release!

🎙️Folge 4: 𝗗𝗮𝘀 𝗠𝗮𝗹𝗶𝗴𝗻𝗼𝗺 𝘂𝗻𝗱 𝗱𝗮𝘀 𝗠𝗶𝗸𝗿𝗼𝗯𝗶𝗼𝗺

🦠Wirkt sich das Mikrobiom auf die Krebsentstehung aus?

🧪🚨Ja, sagt Christoph Stein-Thoeringer. Ziel seiner Forschung sind personalisierte Medikamente gegen Darmkrebs oder Bauchspeicheldrüsenkrebs.

open.spotify.com/episode/62hK...

🔬 New pathoblocker is to stop Salmonella infections early on

Possible alternative treatment method for infections with antibiotic-resistant germs.

📖 Study: tinyurl.com/2s3u4hwj

#Pathoblocker #Salmonella #Pathogenicity #AMR @dzif.bsky.social @unituebingen.bsky.social @mpi-bio-fml.bsky.social

New reprint from the team: Lead by @nike-wagner.bsky.social, we used our native metabolomics setup to shed new light onto the function of the CutA protein.
www.biorxiv.org/content/10.1...

Fig 9 from original publication: Bacterial culturability in the stationary phase is dependent on (p)ppGpp-driven GTP depletion. Uncontrolled, high levels of GTP (low ATP) in the (p)ppGpp0 mutant resulted in membrane disorder and decreased PMF. The lower PMF could at least in part be linked to transcriptional downregulation of nucleotide-sensitive genes of the respiratory chain. Maintenance of respiratory chain activity under (p)ppGpp positive/low GTP conditions likely accounts for the observed tolerance of stationary phase cells to bactericidal antibiotics.

Study shows that (p)ppGpp-controlled GTP homeostasis is essential for maintaining the proton motive force.

This ensures #bacterial survival and #antibiotic tolerance.

Study by Andrea Salzer et al. points to new approaches to fight persistent infections:

shorturl.at/HtJ6N

@wolzc.bsky.social

PhD student / doctoral candidate in Infection Biology AUREUS is a multidisciplinary European Training Network built to counteract multidrug resistant Staphylococcus aures infections, funded by Marie Sklodowska-Curie Doctoral Network (MSCA-DN).

You have a strong background in molecular microbiology and look for a PhD position? Join us in #Tubingen in an international, enthusiastic team team, in an excellent research environment of the EU-funded #AUREUS program
euraxess.ec.europa.eu/jobs/328844
@cmfi.bsky.social

How Staph. lugdunensis controls production of its anti-S. aureus effector lugdunin
@cmfi.bsky.social @dzif.bsky.social

The human microbiome-derived antimicrobial lugdunin self-regulates its biosynthesis by a feed-forward mechanism
journals.asm.org/doi/10.1128/...