Jason Plemel

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Three in two weeks. Could not be more proud of the newly minded Dr. Sameera Zia after successfully defending her PhD yesterday. This bright young star will do amazing things! Also, a huge thanks to @nachoriko.bsky.social for making the trip to Edmonton to serve as an external examiner

Figure 4 (L) Density maps depicting the spatiotemporal expression patterns of Il34 and Csf1 transcripts in RNAscope™ across development. Warmer colours indicate greater, while cooler colours indicate lower, transcript density.

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation

Read this Research Article from our special issue on lifelong development #LifelongDevSI, by Brady Hammond, @jrplemel.bsky.social & co.:
journals.biologists.com/dev/article/...

Excited to get going for the 2025 #endMS_SummerSchool !
It takes a village! Look at all the welcome packages for those who make this event happen

Two in one week! An amazing MSc Defence for Rebecca John, co-supervised by Karim Fouad and myself.

Super proud of Brady Hammond for successfully defending his PhD today. Well done Brady!

Thank you @ghazeskandari.bsky.social !

Wonderful collaborators supported this work, Steve Lacroix, @bradleykerr.bsky.social, and @markcembrowski.bsky.social!

Funding from @nserc-resnet.bsky.social

Surprisingly, in transgenic mice with more developmental microglia proliferation, CSF1 and IL34 were unchanged, meaning that other factors are involved in regulating microglia proliferation.

To get at this, Brady tested many factors and found that only CSF1R ligands like CSF1 and IL34 promote microglia proliferation. Both CSF1 and IL34 are found in the developing brain to regulate microglia proliferation.

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation Summary: In vitro and in vivo investigations indicate that CSF1 and IL34 may partially regulate the developmental proliferation of microglia in the mouse hippocampus and cortex, but an additional laye...

Just out, recent work from the Plemel lab by the talented Brady Hammond. We sought to understand the factors that regulate microglial proliferation during development.
journals.biologists.com/dev/article/...

Amazing work by @iammadho.bsky.social 👇
Check it out

MSc/PhD Position at the Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada – Canadian Association for Neuroscience Dr. Deepak Kaushik, Assistant Professor at the Faculty of Medicine, Memorial University of Newfoundland (MUN, St. John’s, Canada), is currently recruiting MSc/PhD fellows to join a CIHR-funded…

Graduate student and post-doc (Neuroimmunology & High-Throughput Immunometabolic Profiling in MS) positions available in Dr. Deepak Kaushik's laboratory at Memorial University #neurojobs can-acn.org/msc-phd-posi... can-acn.org/postdoctoral...

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease

@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992

Congratulations to all accepted SS & SPRINT applicants. The application quality was outstanding but sadly we are unable to accept everyone. A truly national🍁program. Can't wait to meet you in Edmonton. @ualberta.bsky.social, @jrplemel.bsky.social, @rimuhc.bsky.social, @healthsciences.mcgill.ca

Check out this exciting work by @philgrossphd.bsky.social in the @jkhuang.bsky.social lab! Thanks for asking us to be a part of it

Bye bye 👋🏽 🇺🇸 beer, wine, & liquor

The scene at our local LCBO

#capoli

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I knew this would happen, but it's still surreal to hear another nation's leader talk to us in a televised address the way US presidents have historically spoken to the citizens of countries led by dictators and despots.

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

I hope you haven’t missed this awesome new study by
@caromenard666.bsky.social’s team, where the dreamy keys worlds #astrocyte and #BloodBrainBarrier coexist 🤩🥰

A special thanks to Rebecca John who did such a great job with this project. Also for the funding from International Spinal Research Fund and the Christopher and Dana Reeve Foundation with support CIHR and CRC

Reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states - Journal of Neuroinflammation Background Rehabilitative training is an effective method to promote recovery following spinal cord injury (SCI), with lower training efficacy observed in the chronic stage. The increased training eff...

link.springer.com/article/10.1...

Check out a recent paper by Karim Fouad and my groups examining how reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states

Oligodendrocyte precursor cells facilitate neuronal lysosome release - Nature Communications Oligodendrocyte precursor cells (OPCs) play a multifaceted role in the brain. Here, the authors show that OPCs regulate neuronal metabolism by forming contacts with neuronal somata, facilitating lysos...

Oligodendrocyte precursor cells facilitate neuronal lysosome release

Wise words from another Nobel laureate.

Cool new manuscript from the Huang lab!!

Old article but poignant as ever.

Success in science is far more than science alone.

Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages
www.science.org/doi/full/10....

congratulations to @pryprk.bsky.social for her recent review article in #GLIA on the role of lipids in microglial function.

onlinelibrary.wiley.com/doi/full/10....

The postdoctoral blueprint part one: creating a niche

How to make the most out of PostDoc time?
www.cell.com/trends/cell-...
"In summary, start early, do research, build a network, establish your niche, and apply for funding of your own."