RNA 3' ends and beyond
Precisely defining transcription unit boundaries across eukaryotic genomes is fundamental to understanding individual gene function and regulation. The multifaceted process of RNA 3' end formation esβ¦
meetings.embo.org/event/26-rna3
To all 3' end (and RNA, in general) enthusiasts. I'm organising a great conference in Oxford 7th-11th Sept with @lapassmore.bsky.social and Christine Mayr. The lineup of speakers is brilliant! Registration closes 4th May. Please consider it!
05.03.2026 12:21 β
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Beautiful detective work disentangling what is the actual trigger for cell death upon transcriptional arrest π§ͺ
14.12.2024 15:09 β
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Job Details
Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you!
1/n
05.03.2026 21:35 β
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GeneWiz have worked for me in the past. Anda recently applied something very large and repetitive for us (not promoter but I am still in awe). Twist rarely bother with anything remotely tricky and then give up pretty easily other times, so Iβm not surprised by this.
05.03.2026 14:11 β
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Check out our new review in Nature Reviews Genetics on de novo emerged genes and proteins. How they emerge, are lost and persist - and how de novo emerged proteins relate to randomized proteins! @bornberglab.bsky.social www.nature.com/articles/s41...
28.01.2026 18:23 β
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Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...
More functional data, many thousands of words removed, and a few other updates from last year's preprint.
12.02.2026 11:22 β
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The results are finally in! ππ»π§¬
I'm thrilled to announce that the manuscript for the Bits to Binders protein design competition is out on bioRxiv! Here's a summary of our findings, including some simple criteria that nearly *double* success rates when applied as a filter π§΅
04.03.2026 15:01 β
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Wow I did not know that RNA-seq was being used to inform treatment. My current chemo has just been informed by genome sequencing of the biopsy but I have been given limited access to it. And certainly no mention of RNA-seq.
04.03.2026 15:02 β
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New preprint from
@novoalab.bsky.social !
Which tRNAs are used by ribosomes during translation?
We introduce tRIBO-seq, a nanopore method to sequence ribosome-associated tRNAs and track how the active tRNA pool changes across stress conditions.
www.biorxiv.org/content/10.6...
Thread π
04.03.2026 09:25 β
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Please check out our latest #preprint to study #ACTIVELY TRANSLATING #tRNA populations and their dynamics upon #stress :) This was an wonderful collaborative effort between @novoalab.bsky.social @immagina.bsky.social and #Soares teams - thank you for making this possible!
04.03.2026 10:11 β
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13/ Overall, our data suggest that GA-independent developmental phenotypes are evolutionary conserved in #MyMarchantia, while AMS-related phenotypes are not. We propose that GA-dependent DELLA functions evolved in vascular plants and were co-opted as an additional layer of control during AMS.
04.03.2026 05:41 β
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1/ β¨ New preprint alert β¨
It is my pleasure to share:
"Stepwise evolution of the developmental and symbiotic functions of DELLA in land plants"
Here we investigated the role of the single GRAS transcription factor DELLA in #MyMarchantia
doi.org/10.64898/202...
#PlantScience
A thread...
04.03.2026 05:20 β
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As we lead up to #IWD2026, weβre celebrating Kristina Gagalova, Bioinformatics Scientist and part of AGGI, whose work bridges cuttingβedge genomics with realβworld agricultural impact.
@curtinuniversity.bsky.social, #GRDC
04.03.2026 03:00 β
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Nah eukaryotes are just ribosomes making ribosomes but with extra steps.
Meiosis seems to be the central innovation in eukaryotes that sets the stage of a lot of other things including multicellularity. I have written something on this but trying to find a good venue for it.
03.03.2026 13:37 β
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And there's also this
bsky.app/profile/mkru...
03.03.2026 13:23 β
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A symbiotic origin of the ribosome?
Abstract. The origin of life is one of the great mysteries of science. Of the multiple unsolved problems, the origin of the translation system (the means b
"we propose that the protoribosome was a parasite (...). If this view is correct, then like the spliceosome in the stem eukaryote, a repurposed host-parasite interaction led to a dramatic change in cell biology at the base of the tree of life, in this case leading to the exit from an RNA world"
02.03.2026 18:43 β
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Very happy about this nice piece of work by @eugeniapitsili.bsky.social on developmentally controlled cell death in plants @dev-journal.bsky.social⬠!
Special thanks also to @ingridtsang.bsky.social for a terrific editorial job bringing out the best of this manuscript!!
doi.org/10.1242/dev....
03.03.2026 08:21 β
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Morning.
23.11.2025 05:31 β
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With Eugene Koonin, we propose a concept of βthe selfish ribosomeβ, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cellβs resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268
03.03.2026 08:58 β
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RNA Splicing Lab - JOIN US
Are you interested in investigating basic mechanisms in splicing regulation and gene expression?
Our research group was launched in September 2024 and is hosted at the Institute of Molecular Infection...
We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: www.beuschlab.org/join-us
Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with people who might be! π§ͺπ§«
02.03.2026 15:44 β
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Prepare your best art for AR(t)RBMP
Plant Molecular Biology Meeting
π Bilbao
ποΈ July 1-3
rbmp2026.com/RBMP/en/info
Thanks to #RBMP2026 organizing committee, @danielmarinoehu.bsky.social
@ibmcp.bsky.social support & my partner in crime for these fun initiatives @javijevi.bsky.social
#PlantScience
02.03.2026 09:39 β
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How should I keep spores of Marchantia polymorpha subsp. ruderalis? Although I have kept them at -30ΛC for 1-2 months, they don't germinate so far.
02.03.2026 08:00 β
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Great to see this one out. I agree it was challenging but watching it unfold was definitely exciting. The team worked brilliantly, truly thankful!
02.03.2026 08:51 β
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