Aakash Grover

Scientist on Friday, superfan on Sunday. Balance. 😌

Delhi Crime Season 3🤯

Histone PARylation factor 1: a review of its role in the DNA damage response Abstract. Although poly-(ADP ribose) polymerase 1 (PARP1) and PARylation of histones have been known for over 50 years and have been successfully targeted

Beautiful review from J. Rudolph on Histone PARylation factor 1: a review of its role in the DNA damage response url: academic.oup.com/nar/article/...

Dead Poets Society🤌🥲

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

Just submitted this a few hours ago. We ❤️ biorxiv. This is work from my student Payal Arora who will defend her thesis very soon!

I don’t think this is a controversial opinion but …

Indian style mutter-paneer definitely deserves the Nobel peas prize this year

www.indianhealthyrecipes.com/matar-paneer...

We have added additional functionalities including a collapsible protein pane and zoom scrolling. domaindesigner.farnunglab.com

Protein Domain Designer tool for the generation of publication-ready protein domain diagrams

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com

The histone chaperone Spt6 controls chromatin structure through its conserved N-terminal domain During transcription, histone chaperones are essential for nucleosome disassembly and reassembly. Warner et al. provide evidence that the Spt6 N-terminal domain is essential for this process. The Spt6 NTD interacts directly with histones and is required for normal chromatin structure. Genetic evidence closely connects Spt6 with the histone chaperone FACT.

The histone chaperone Spt6 controls chromatin structure through its conserved N-terminal domain

😂😂😂

Collective homeostasis of condensation-prone proteins via their mRNAs - Nature The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.

This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...

This Wednesday at #FragileNucleosome seminar, we are excited to host Ali Wilkening and @schvartzman.bsky.social to tell us about amazing work they are doing!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions The genome is compacted in the nucleus through a hierarchical chromatin organization, ranging from chromosome territories to compartments, topologically associating domains (TADs), and individual nucl...

New preprint is up, led by former postdoc Braulio Bonilla.
We know these remodelers regulate nucleosome positions and occupancy, but do they have a role in regulating higher order chromatin structure? We take a peek for BAF and INO80C.
www.biorxiv.org/content/10.1...

Fantastic preprint from my colleague at Pitt. Was presented at recent CSH meeting #moet2025 #moet

Had the most amazing time at Cold Spring Harbor Laboratory! #moet2025

Fragile Nucleosome Fall Seminars: September 10 Grace Bower, Kvon Lab @ UC Irvine, USA Jennifer Phillips-Cremins, UPenn, USA September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA Juanma Schvartzman, Columbia University, USA October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA Alex Federation, Talus Bio, USA October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland Seungsoo Kim, UC Irvine, USA November 5 Hannah Long, University of Edinburgh, UK Jeff Vierstra, Altius Institute, USA November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada Sarah Teichmann, University of Cambridge, UK December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain Jonathan Henninger, Carnegie Mellon, USA December 17 Rebecca Berrens, Oxford University, UK Jean-Benoit Lalanne, University of Montreal, Canada

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...

A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes Abstract. The nucleosome remodeler Chd1 is required for the re-establishment of nucleosome positioning in the wake of transcription elongation by RNA Polym

Our collaborative paper with the Arndt lab is out today: doi.org/10.1093/nar/... (originally bioRxiv: www.biorxiv.org/content/10.1...). Here we asked the question of how CHD1 localizes to chromatin.

🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...

Widespread epistasis shapes RNA polymerase II active site function and evolution - Nature Communications The active site of RNA Polymerase II is highly conserved. Here the authors show that mutations can propagate effects across the enzyme and alter genetic behavior of distal residues, demonstrating plas...

Final version of Bingbing Duan’s main thesis work is out now now in Nature Communications @natureportfolio.nature.com www.nature.com/articles/s41... I’m so pleased with this study that we’ve been working on for so long #epistasis #transcription #geneexpression 1/

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Two shy dinos caught on the kiss cam! 📸

I am pleased to announce Reactor—the complex formation calculator for multi-component protein complex formation experiments. Developed by the Farnung Lab @harvardmed.bsky.social.
reactor-farnunglab.pythonanywhere.com 1/n

New paper:
More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs.

www.biorxiv.org/content/10.1...

Yes, yes, and yes!
www.nature.com/articles/d41...

A global genetic interaction map of a human cell reveals conserved principles of genetic networks We generated a genome-scale, genetic interaction network from the analysis of more than 4 million double mutants in the haploid human cell line, HAP1. The network maps ~90,000 genetic interactions, in...

www.biorxiv.org/content/10.1... - Awesome!

Finally found this in Pittsburgh!!! This is so good!😁

This was so heartbreaking but beautiful!

Excited to share our new paper in @cellreports.bsky.social that reshapes our understanding of chromosome organization's deep evolutionary roots! Our work dives into the origins of the machinery that structures our very genomes.

🔗: doi.org/10.1016/j.ce...

#Genomics #Evolution #CellBiology #LECA

Application to speak in the Fragile Nucleosome series Thank you for your interest in our seminar series! We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...

FN is taking a summer vacation 🏖️, but we'll be back in September with more exciting talks on chromatin and transcription!

If you've got a new story you'd like to share with the FN audience this fall, fill out the form here: docs.google.com/forms/d/e/1F...