Nucleic Acids Research

Dr. Yoshikazu Hattori generated the mutants and performed NMR analysis, while Prof. Yoshiyuki Tanaka directed and conceptualized the entire project.

Prof. Masaki Unno led the crystallographic analysis, while Dr. Masayuki Morikawa contributed kinetics and mass spectrometry to uncover the mechanism.

Capturing a glycosylase reaction intermediate in DNA repair by freeze-trapping of a pH-responsive hOGG1 mutant Abstract. The human 8-oxoguanine DNA glycosylase 1 (hOGG1) is a bifunctional DNA repair enzyme that possesses both glycosylase and AP-lyase activity. Its A

⭐NAR Breakthrough!⭐
🧬 New structure reveals a hidden step in DNA repair.
Researchers captured a hemiaminal-type intermediate of hOGG1, shedding light on its catalytic mechanism.
📖 doi.org/10.1093/nar/...
#NARBreakthrough #DNArepair #StructuralBiology #hOGG1 #Crystallography #Enzymes

Spontaneously directed loop extrusion in SMC complexes emerges from broken detailed balance and anisotropic DNA search Abstract. DNA loop formation by structural maintenance of chromosome (SMC) proteins, including cohesin, condensin, and the SMC5/6 complex, plays a pivotal

⭐NAR Breakthrough!⭐
Bonato et al. propose a model for how the yeast #condensin SMC complex drives persistent #DNAloopextrusion, using #atomicforcemicroscopy and #moleculardynamics.

Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #SMC #biophysics #genomefolding #yeast

Now Hiring - Executive Editor

❓Do you have expertise in prokaryotic molecular biology, including transcriptional regulation, metabolism, physiology, and protein–nucleic acid interactions?

➡️ If so, apply to become @narjournal.bsky.social‬'s next Executive Editor! Don't miss the opportunity: oxford.ly/4f5p57M

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa Abstract. Transfer RNA (tRNA) modifications have emerged as critical post-transcriptional regulators of gene expression affecting diverse biological and di

⭐NAR Breakthrough!⭐
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.

⭐NAR Breakthrough!⭐

AlphaFold2 predicted LSI–RDF interactions and experimentally validated several new functional pairs.

@phoeberice.bsky.social @femijohn.bsky.social

doi.org/10.1093/nar/...

#NARBreakthrough #SyntheticBiology #AlphaFold2 #GenomeEditing #ComputationalBiology

⭐NAR Breakthrough!⭐

🧬Mutation rates at the 3' end of DNA primer strands vary with run length. 4 TIM pathways in yeast DNA replication may be universal and linked to human disease.

📖 doi.org/10.1093/nar/...

#YeastGenetics #Genomics #DNAReplication #MolecularBiology

📢 The 23rd annual NAR Web Server Issue is live!

🧬 Featuring 72 new web servers across scientific & medical fields.

👏 Huge thanks to all authors, editors and reviewers!

🔗 Issue: lnkd.in/dVyUdAVN
📝 Editorial: lnkd.in/d9qh3QEh

#NARWebServer #GeneticSoftware #MolecularBiology #OpenAccessIssue

Congratulations on your 10th paper and thank you for choosing to publish it with NAR! 🥳

🔬 A new study in NAR Genomics and Bioinformatics compares short-read and long-read sequencing, aligning results at the cDNA level using UMIs 🧬

📖 Dive into the full article: doi.org/10.1093/narg...

#Sequencing #Bioinformatics #GeneExpression #Genomics #UniqueMolecularIdentifier #NARGAB

Images of the co-authors, Vassiliki Stamatopoulou and Adamantia Kouvela.

📣NAR Breakthrough Article!📣

✂️ Removal of a single tRNA^Gly gene copy in Staphylococcus aureus via CRISPR weakens the cell wall, biofilm formation and increases antibiotic susceptibility💊

📖 doi.org/10.1093/nar/...

#Microbiology #CRISPR #tRNA #AntibioticResearch #BacterialGenetics

We're excited to see our Senior Executive Editor, Dr Julian Sale, feature in the BBC News discussing the development of the Synthetic Human Genome Project! 🧬

📽️ lnkd.in/ehYAAcFK

📖 lnkd.in/e7aYiyJ4

#HumanGenome #SyntheticBiology #Genomics #GenomeProject #MolecularBiology

📣 New NAR Breakthrough article! 📣

🧬 Cells resist starvation through a nutrient stress splice switch 🧬

👉 Read the free full text here: lnkd.in/eeE8KM8i

#NARBreakthrough #RNAsplicing #YeastGenetics #Introns #Spliceosome

🚨 Check out the latest #Breakthrough research article published in NAR detailing how fungal plant pathogens use RNAi-mediated DNA methylation as a viral defense mechanism.

👉 Read the full article here: doi.org/10.1093/nar/...

#DNA #Methylation #Fungi #Virus

SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression Abstract. SRSF2 (serine/arginine-rich splicing factor 2) is a critical regulator of pre-messenger RNA splicing, which also plays noncanonical functions in

New findings in #NARcancer ! Overexpressed SRSF2 drives #transcription & #replicationstress, causing DNA double-strand breaks. Read full article here: doi.org/10.1093/narc... #CancerResearch #LungCancer #DNArepair #Cancertherapy #openaccess @ugrenoblealpes.bsky.social

📣 A new #Breakthrough article published in NAR reveals how ribosomes in eukaryotes maintain high levels of accuracy during translation compared to prokaryotes. 👉 Read the full article here: academic.oup.com/nar/article/... #Ribosomes #RNA #Translation

Retinoic acid signaling via RAR agonists drives neural lineage formation. Transcriptomic analysis in stem cells and brain organoids revealed diverse neuronal subtypes, retina-like structures, and microglia.

Read the NARMME article here: doi.org/10.1093/narm...

#StemCells #VitaminA #RARAgonists

Autoimmune diseases stem from the immune system’s “bad memory.” IgAim targets B cell antibodies to erase these, offering a new way to treat autoimmune diseases and B-cell leukemias.

Full text in NARMME: doi.org/10.1093/narm...

#Antibodies #Autoimmunediseases #Immunotherapy #Bleukemia #NARMolMed

Monitoring monomer-specific acyl–tRNA levels in cells with PARTI Abstract. We describe a new assay that reports directly on the acylation state of a user-chosen transfer RNA (tRNA) in cells. We call this assay 3-Prime Ad

✨ New C-GEM Breakthrough Article in
@narjournal.bsky.social

Monitoring monomer-specific acyl–tRNA levels in cells with PARTI

Congratulations to Meghan, @carlyschissel.bsky.social, Izzy, Cameron, and Alanna!

academic.oup.com/nar/article/...

Many congratulations on your Breakthrough article with NAR! 🤩

Congratulations on your publication with NAR! 🎉

Thank you for choosing NAR to publish your insightful article! 🤩

Congratulations on your publication with NAR! 🎉

Many congratulations on your Web Server publication and thank you for choosing NAR! 🤩

Congratulations on your Web Server publication! 👍🎉

A new @NARCancer study shows ECM stiffness drives prostate cancer aggression 😱—with softer ECM boosting androgen response 💪. ECM isn’t just a structure; it also acts as a signal. Read the full article here: doi.org/10.1093/narc... #ProstateCancer #ECM #NARCancer #ATACseq #RNAseq @uniuef.bsky.social

TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress Abstract. Oncogene activation in normal untransformed cells induces DNA replication stress and creates a dependency on DNA damage response (DDR) mechanisms

Oncogene activation causes #DNAreplicationstress, forcing cells to rely on #DNArepair. In #KRASdriven #PDAC, deletion of TRIP13 causes HR defects and cells become sensitive to #PARPinhibitors, making TRIP13 a new #therapeutictarget. Read the full article here: doi.org/10.1093/narc... #NARCancer

NAR #Breakthrough Article: doi.org/10.1093/nar/... Authors Pictured: Meghan A. Pressimone (First Author) and Alanna Schepartz (Corresponding Author) - Part2