Nucleic Acids Research

⭐NAR Breakthrough ⭐
New study identifies a 6-nt miR-17 site in the #PKD1 3′UTR that limits PKD1 expression. Targeting this site boosts PKD1 protein and reduces cyst burden in #ADPKD models—highlighting a promising oligo-based strategy @vishal-d-patel.bsky.social
🧬Read more: doi.org/10.1093/nar/...

⭐NAR Breakthrough! ⭐
🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/...
#NARBreakthrough

🌟 2026 Nucleic Acids Research Database issue 🧬
182 papers, 84 new databases, plus Breakthrough Articles on JoGo (global long‑read haplotypes) and So3D (3D spatial genomics). Browse the issue and Editorial: academic.oup.com/nar/issue/54...
academic.oup.com/nar/article/...
@danielrigden.bsky.social

⭐NAR Breakthrough! ⭐

🔬 #tRNA modifications fine-tune #translation; in yeast, their loss slows #ribosomes at hard-to-read codon pairs, causing collisions ⚠️, and cells deploy quality control pathways to prevent #proteotoxicstress and ensure survival.
🧬Read more: doi.org/10.1093/nar/...

👏 Congratulations to @helena-stafflinger.bsky.social Helena Stafflinger, @en-hxnu-enment.bsky.social Hermann Schindelin, Jens Wöhnert and their team on this elegant and paradigm-shifting study uncovering unexpected principles of RNA G-quadruplex formation! @uniinnsbruck.bsky.social

⭐NAR Breakthrough! ⭐
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...

#NARBreaktrhough #RNA #StructuralBiology

🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/...
#NARBreakthrough #RibosomeBiogenesis

Congratulations @simrouxvirus.bsky.social
@maureenbug.bsky.social
@titus.idyll.org
@taylorreiter.bsky.social
@ucdavis.bsky.social on this fantastic publication, and thank you for this informative thread!
#NARGenomics #NARGAB #EditorsChoice #GenomeAssembly #Sequencing

DNA repair helicases: from mechanistic understanding to therapeutic implications Abstract. The maintenance of genomic integrity is paramount for normal cell physiology and survival as well as avoidance of carcinogenesis. Cellular DNA is

📢 Read this timely review in #NARCancer! 🧬
Gueble and Menon highlight the critical role of #DNAhelicases in linking #DNAdamage recognition with #repair. The review includes a curated table of #clinicaltrials on #helicaseinhibitors.
Read it here: doi.org/10.1093/narc... @yalepress.bsky.social

We're excited to release metaTraits.embl.de! 🦠 Interactively explore 140+ 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗽𝗵𝗲𝗻𝗼𝘁𝘆𝗽𝗶𝗰 𝘁𝗿𝗮𝗶𝘁𝘀, harmonized & integrated from culture-derived collections 🔬 & genome-based predictions 🧬 for >2M MAGs & genomes.

Publication at NAR: doi.org/10.1093/nar/... @narjournal.bsky.social #microsky 🧵 1/8

ChEBI: re-engineered for a sustainable future Abstract. Chemical Entities of Biological Interest (ChEBI) is a high-quality, manually curated, and open-access database and ontology of chemical entities

From one of the @ebi.embl.org team, published in @narjournal.bsky.social #NARDatabaseIssue | ChEBI: re-engineered for a sustainable future | #Bioinformatics #Database #Chemistry #OpenData #OpenScience #ChemicalEntitiesofBiologicalInterest 🧬 🖥️🧪🔓
⬇️
academic.oup.com/nar/advance-...

THRESHOLD: a comprehensive transcriptomic analysis tool for evaluating gene saturation and impact in disease progression Abstract. Gene expression studies are fundamental in molecular biology, offering insights into development, disease progression, and therapeutic targets. T

📢Paper spotlight in NAR Cancer 🧬

A new study in #NARCancer introduces #THRESHOLD, a novel framework that measures gene expression “saturation” 📊—how consistently genes are expressed across cancer patients!

Read the full article here: doi.org/10.1093/narc...
#Transcriptomics #PrecisionOncology

HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences Abstract. Deciphering the functional effects of genetic variants, especially those inherited together on the same haplotype, remains a major challenge in h

🚨 Out in NAR @narjournal.bsky.social!

Introducing HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences.

📄 Paper: doi.org/10.1093/nar/...
💻 DB: bcglab.cibio.unitn.it/hapscoredb

#Bioinformatics #Genomics #ProteinLanguageModels #CompBio

⭐ NAR Breakthrough! ⭐
🦠 New study shows phage X1 hijacks Yersinia's enterocolitica flagellum to inject its DNA directly into the cytosol. Yersinia, though, strikes back!
🦠 A fascinating look at the #dualrole of #flagella in #viralentry and #bacterialimmunity.
🧬 Read more: doi.org/10.1093/nar/...

⭐ NAR Breakthrough! ⭐
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense

⭐ NAR Breakthrough! ⭐

🔬 New study by Betancurt et al. uses #PacBio single-molecule sequencing to build a long-read fidelity assay that reveals how different #DNApolymerase families make distinct errors.
🧬 Read more: doi.org/10.1093/nar/...
@nebiolabs.bsky.social @pasteur.fr
#NARBreakthrough

⭐ NAR Breakthrough! ⭐

A community-driven collection uniting 52 phages, 74 Klebsiella isolates, and extensive genomic + phenotypic data — all freely available at klebphacol.org.
🧬 Learn more: doi.org/10.1093/nar/...
@fnobrega.bsky.social @danielarothschild.bsky.social #antimicrobialresistance

📣 Authors wanted! Submit to NARMME's Special Collection on Repeat Expansion Diseases by Jan 2026🧬

🔍Find out more: academic.oup.com/narmolmed/pa...

👉Submit: mc.manuscriptcentral.com/narmme

#CallForPapers #Genomics #RareDiseases #NARMME

🧬 New in NARGAB: A fast, scalable CHT method identifies genomic regions with shared effects across traits. Applied to psychiatric pleiotropy and cucumber virus resistance.

Read: doi.org/10.1093/narg...

#CHT #MultiTraitAnalysis #PsychiatricGenetics #PlantGenomics

🧬 New in NARMME: RNA splicing tweaks rescue tau toxicity in C. elegans. Modifying tri-snRNP proteins rescues tau-induced deficits in transgenic C. elegans, restoring behaviour, neurodegeneration and extending lifespan.
Read: doi.org/10.1093/narm...
#Alzheimers #RNAsplicing #Neurodegeneration

⭐ NAR Breakthrough! ⭐
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org

#NARbreakthrough #ChromosomeSegregation

Five years ago, Dr. Doudna @jenniferdoudna.bsky.social and Dr. Charpentier won the #NobelPrize for #CRISPR/Cas9, revolutionizing gene editing and science as we know it. 🎉🎉Celebrate this milestone with our #specialcollections academic.oup.com/nar/pages/cr... and academic.oup.com/nar/pages/cr...

Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant Abstract. Distal 1q21.1 deletions and duplications are associated with variable phenotypes including autism, head circumference and height defects. To eluc

⭐ NAR Breakthrough! ⭐
New research highlights CHD1L in the chromosome 1q21.1 region—linked to #autism, head size & growth.
🧠 It controls #DNApackaging & genes for #braindevelopment, #cellfate & #connectivity.
Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Neuroscience @igbmc.bsky.social

🧬 New in NARGAB: authors compared human exome sequencing kits, showing how design differences impact capture efficiency and downstream analysis. Useful insights for choosing the right kit!

📖 Read: doi.org/10.1093/narg...

#ExomeSequencing #Genomics #Bioinformatics #NARGAB

🧬New in NARGAB: a composite hypothesis testing (CHT) method to find genetic regions affecting multiple traits is described which is efficient, scalable and applied to psychiatric disorders and viral resistance in cucumber.

Read here: doi.org/10.1093/narg...

#Genomics #CHT #Bioinformatics #NARGAB

🤰 New research in NARMME reveals that uterine glands, not just eggs, are sensitive to maternal aging. 🧬 FOXC1 marks early dysfunction, reshaping how we understand fertility decline.

📖 Read more: lnkd.in/eahrVbMt

#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication

💡 New in NARMME: TRL1 enzyme from Candida glabrata changes shape to control RNA repair, vital for fungal survival. Its absence in humans makes it a promising antifungal drug target.

📖 Read more: doi.org/10.1093/narm...

#TRL1 #RNARepair #AntifungalResearch #DrugDiscovery #NARMME #OpenAccess

🔬 New study in NARMME explores how azvudine (FNC) targets HIV-1 RT & SARS-CoV-2 RdRp🧬

📖 doi.org/10.1093/narm...

#Azvudine #AntiviralAgents #HIVResearch #SARSCoV2 #NARMolecularMedicine #OpenAccessPublication

💡A new RNAi strategy described in NARMME embeds miR-based shRNAs into a gamma-retroviral intron, enabling gene knockdown and protein coexpression with high viral titers.

📖 doi.org/10.1093/narm...

#RNAi #GeneTherapy #RetroviralVectors #MolecularBiology #NARMME #OpenAccessPublication

🧬 A new review in NARMME explores how chromatin preserves cell identity and how its breakdown may drive diseases like neurodegeneration and cancer.

📖 doi.org/10.1093/narm...

#Epigenetics #Chromatin #CellBiology #Genomics #Neuroscience #MolecularBiology #OpenAccess #NARMolecularMedicine