@currentmedscience.bsky.social
Current Medical Science is a peer-reviewed journal publishing original, innovative & influential insightful reviews, comments, & special topic articles across diverse medical disciplines, including biomedicine, public health, and related fields.
TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway
A randomized clinical study demonstrates that the Jianpi Shengxue tablet effectively treats #RenalAnemia by significantly improving red blood cell counts, iron metabolism markers, and systemic symptoms compared to standard #IronTherapy. #Medsky
Read more: doi.org/10.1007/s115...
TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway
TRPC6 knockout alleviates #RenalFibrosis by reducing fibrotic markers, #apoptosis, and #inflammation, while downregulating the PI3K/AKT/GSK3Ξ² pathwayβsupporting TRPC6 inhibition as a promising therapeutic strategy for #ChronicKidneyDisease.
Read more: doi.org/10.1007/s115...
Crosstalk among Oxidative Stress, Autophagy, and Apoptosis in the Protective Effects of Ginsenoside Rb1 on Brain Microvascular Endothelial Cells: A Mixed Computational and Experimental Study
#Ginsenoside Rb1 protects BMECs from #Ischemia-reperfusion injury by regulating #Autophagy, #Apoptosis, and #OxidativeStress via SQSTM1/p62, ATG5, and HIF-1Ξ±, highlighting these as potential #TherapeuticTargets for #IschemicStroke.
Read: doi.org/10.1007/s115...
Therapeutic Effectiveness of Leukocyte- and Platelet-rich Fibrin for Diabetic Foot Ulcers: A Retrospective Study
Adding leukocyte- and platelet-rich fibrin to standard care significantly improved wound healing in #DiabeticFootUlcer patients, with faster early healing, high rates of epithelialization, and consistent benefits across severity grades. #DiabeticWound
Read: doi.org/10.1007/s115...
Clinical Value of the Quantitative Flow Ratio to Predict Long-term Target Vessel Failure in Patients with In-stent Restenosis after Drug-coated Balloon Angioplasty
Study findings indicate that post-PCI quantitative flow ratio (QFR) is a high-value predictor for long-term target vessel failure in in-stent #Restenosis patients, where a QFR of 0.925 correlates with increased clinical risk.
Read: doi.org/10.1007/s115...
Standard-definition White-light, High-definition White-light versus Narrow-band Imaging Endoscopy for Detecting Colorectal Adenomas: A Multicenter Randomized Controlled Trial
A multicenter trial shows that standard- and high-definition #colonoscopy have comparable detection efficiency, and HD-WL/HD-NBI offer no advantage over SD-WL, underscoring that improving #endoscopy quality may better optimize screening resources.
Read: doi.org/10.1007/s115...
World Cancer Day
On this #WorldCancerDay, letβs honor the "#UnitedbyUnique" theme by advocating the integration of patient-reported outcomes with molecular profiling to drive personalized #PrecisionOncology.
#FightCancer #CancerAwareness
For articles related to cancer: link.springer.com/journal/11596
TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response
TOPK was overexpressed in patients with moderately to poorly differentiated CRC receiving #Radiotherapy, while its knockdown significantly enhanced the #Radiosensitivity of CRC cells by reducing the #DNAdamageResponse.
Read more: doi.org/10.1007/s115...
Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer: Integrating Bioinformatics Analysis with Experimental Confirmation
Bioinformatic and experimental analyses reveal #SLC9A2 as a #TumorSuppressor in #ColorectalCancer, inhibiting proliferation and metastasis via #MAPK signaling, highlighting its potential as a diagnostic and therapeutic target.
Read: doi.org/10.1007/s115...
TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-Ξ²1/Smad3 Signaling Pathway
TL1A promotes #IntestinalFibrosis by inducing TGF-Ξ²1-mediated intestinal fibroblast activation, proliferation, and collagen deposition via TGF-Ξ²1/Smad3 pathway, highlighting a critical #TherapeuticTarget for #InflammatoryBowelDisease
Read: doi.org/10.1007/s115...
KLF4 Inhibits the Activation of Human Hepatic Stellate Cell In Vitro
KLF4 suppresses HSC activation!
Researchers show #KLF4 maintains quiescence in #HepaticStellateCells by inhibiting proliferation and activation, suggesting it as a potential therapeutic target for preventing and reversing #LiverFibrosis.
Read: doi.org/10.1007/s115...
Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis
This study demonstrates that PCED1B-AS1 expression is upregulated in #HepatocellularCarcinoma, exerting an #Oncogenic role by promoting HCC cell proliferation and invasion via the miR-34a/CD44 axis. #Medsky
Read more: doi.org/10.1007/s115...
Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults: a Cross-sectional Study Based on the NHANES
Elevated #SerumFerritin is strongly associated with #MAFLD and advanced #LiverFibrosis, independent of iron intake; combined with #diabetes, it poses major risk, highlighting #ferritin as a #biomarker and therapeutic target.
Read: doi.org/10.1007/s115...
A Review of Type 1 and Type 2 Intraductal Papillary Neoplasms of the Bile Duct
An overview of the #Epidemiology, #Etiology, pathological classification, diagnosis, imaging features, treatment, and #Prognosis of IPNB, while highlighting the similarities and differences between conventional and novel subclassifications of IPNBs.
Read: doi.org/10.1007/s115...
Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation
This review explores protonβactivated #GPCRs, pHβsensing receptors that modulate #ImmuneResponses, highlighting their roles in #InflammatoryDiseases and future directions for understanding immune regulation under pathological conditions.
Read: doi.org/10.1007/s115...
The Role of Adipose Tissue-derived Exosomes in Chronic Metabolic Disorders
This review summarizes the #Biogenesis, components, and uptake of adipose tissue-derived #Exosomes, describing their role in #MetabolicDisorders and clinical applications while discussing current limitations and future therapeutic perspectives. #Medsky
Read: doi.org/10.1007/s115...
Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits
#CymbopogonCitratus #EssentialOil inhibits #Isoproterenol-induced #cardiomyocyte hypertrophy by suppressing #NLRP3Inflammasome signaling and modulating oxidative phosphorylation complex subunits, highlighting its cardioprotective potential. #CVD
Read: doi.org/10.1007/s115...
Risk Factors Asscociated with Hypokalemia during Postanesthesia Recovery and Its Impact on Outcomes in Gynecological Patients: A Propensity Score Matching Study
In this study, researchers found that #Hypokalemia occurred in 43.75% of gynecological patients recovering from #Anesthesia due to preoperative mechanical bowel preparation, though it had no significant effect on clinical outcomes. #medsky
To read more: doi.org/10.1007/s115...
Clinical Analysis and Mental Health Survey of Hemophilia Carriers: a Cross-sectional Study
Scientists show that #hemophilia carriers in #China frequently harbor identifiable F8/F9 mutations, exhibit variable #ClottingFactor levels with #BleedingRisk in low-level carriers, and display substantial psychological symptom burden.
Read: doi.org/10.1007/s115...
Genetic Analysis of Two Novel GPI Variants Disrupting H Bonds and Localization Characteristics of 55 Gene Variants Associated with Glucose-6-phosphate Isomerase Deficiency
This study identified that most GPI variants cluster in #Exons 3, 4, 12, and 18, and report novel pathogenic compound heterozygous variants that disrupt hydrogen bonds in highly conserved regions, potentially affecting GPIβs tertiary structure. #Medsky
Read: doi.org/10.1007/s115...
Detection of Novel BEST1 Variations in Autosomal Recessive Bestrophinopathy Using Third-generation Sequencing
Researchers report two novel #BEST1 mutations identified by #PacBio #SMRTSequencing in autosomal recessive #Bestrophinopathy, broadening the BEST1 mutation spectrum and highlighting the need for functional studies to advance #GeneTargetedTherapies.
Read: doi.org/10.1007/s115...
ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/Ξ²-Catenin Signaling Pathway
ZNF554 functions as a #TumorSuppressor in UCEC, inhibiting its progression by regulating the RBM5/WNT/beta-catenin signaling pathway, thus highlighting it as both a prognostic #Biomarker and a #TherapeuticTarget for UCEC.
Read: doi.org/10.1007/s115...
Survival Analysis of Patients Undergoing Intraoperative Contrast enhanced Ultrasound in the Surgical Treatment of Malignant Glioma
Scientists show that #ICEUS improves #ResidualTumor detection during malignant #glioma surgery and is linked to better overall and #ProgressionFreeSurvival, highlighting ICEUS as a #prognosticfactor and tool to enhance surgical outcomes.
Read: doi.org/10.1007/s115...
Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms
Using #FluidDynamics to study sidewall & bifurcation #Aneurysms, this study identified Size Ratio (SR) as a key morphological tool for distinguishing rupture risks and guiding #IntracranialAneurysm therapy. #Medsky
Read: doi.org/10.1007/s115...
Effect of an Airbag-selective Portal Vein Blood Arrester on the Liver after Hepatectomy: A New Technique for Selective Clamping of the Portal Vein
This work finds the airbag-selective #PortalVein blood arrester as a novel strategy to reduce #Hepatic #Ischemia/reperfusion injury during #Hepatectomy, highlighting it as a safe & effective approach with fewer #IatrogenicInjuries. #medsky
See: link.springer.com/article/10.1...
Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn
This study shows that MMP13 promotes the formation of #DeepVeinThrombosis (DVT) while suppressing #Podoplanin expression, thereby advancing our understanding of #Thrombosis biology & offering new insights for DVT intervention. #medsky
Read: link.springer.com/article/10.1...
Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats
This study finds that #Scutellarein, a flavonoid isolated from Scutellaria barbata D. Don, demonstrates anti-#Osteoarthritis (OA) effects in rat models, highlighting its potential as a promising candidate for novel drug therapy in OA. #medsky
Read: link.springer.com/article/10.1...
Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreatic Ξ²-cell Dysfunction
#TRPM5 expression decreases in #Lipotoxic #Ξ²celldysfunction while overexpression reverses GSIS impairment & restores #TranscriptionFactor activity, providing a theoretical foundation for novel #Type2Diabetes therapies. #medsky
Read: link.springer.com/article/10.1...
BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway
This study shows that #BoneMarrowMesenchymalStemCells-derived #Exosomes exert protective effects on #PeritonealDialysis-related #PeritonealFibrosis, mediated by #miR27a3p/#TP53 pathway & regulation of #Peritoneal miRNA #Homeostasis. #medsky
Read: link.springer.com/article/10.1...
Risk Factors of Enternal Nutrition Intolerance in Septic Patients: A Case-control Study
This retrospective study investigates early #NeurologicalImpairment in adult patients with #Sepsis, identifying key influencing factors to inform prevention and treatment strategies aimed at improving #ClinicalOutcomes. #medsky
Full article: link.springer.com/article/10.1...
