Current Medical Science

A Prediction Model for Detecting Dysthyroid Optic Neuropathy Based on Clinical Factors and Imaging Markers of the Optic Nerve and Cerebrospinal Fluid in the Optic Nerve Sheath

A noninvasive model combining #OpticNerve imaging and #CerebroSpinalFluid sheath metrics predicts #DysthyroidOpticNeuropathy in #ThyroidAssociatedOphthalmopathy with high accuracy, supporting early detection and risk stratification in clinical practice.

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Analysis of Phenotypes Associated with Deficiency of PAX6 Haplotypes in Chinese Aniridia Families

Through targeted next-generation sequencing, this research identified two novel and two recurring PAX6 mutations and showed macular foveal hypoplasia as a consistent clinical phenotype in the Chinese #Aniridia patient population.

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Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis

A novel Lindqvist-type polyoxometalate MO-4 shows strong anti-breast cancer activity by raising #MitochondrialROS to trigger #mitophagy and #apoptosis, reducing #tumor growth and #metastasis in vivo, highlighting promise as a therapeutic candidate.

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Synergistic Effects of Glutamine Deprivation and Metformin in Acute Myeloid Leukemia

#Glutamine deprivation + metformin treatment inhibits AML cell proliferation & triggers #Apoptosis by suppressing mTOR signaling & increasing ROS levels, suggesting a dual metabolic targeting strategy to overcome #Chemoresistance.

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Silencing MFN2 Drives WNT/β-catenin Nucleation to Reduce Sorafenib Sensitivity in Hepatocellular Carcinoma Cells

Low MFN2 in #HepatocellularCarcinoma activates β-catenin/EMT signaling, boosting invasion and #sorafenib resistance; MFN2 overexpression restores drug sensitivity, highlighting MFN2 as a potential therapeutic target to overcome #drugresistance.
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Development and Validation of a Carbohydrate Metabolism-Related Model for Predicting Prognosis and Immune Landscape in Hepatocellular Carcinoma Patients

Development and Validation of a Carbohydrate Metabolism-Related Model for Predicting Prognosis and Immune Landscape in Hepatocellular Carcinoma Patients

This study established a carbohydrate metabolism-based risk model that predicts survival and immune landscapes in #HepatocellularCarcinoma, providing a precise tool for prognostic stratification and therapy selection.
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This review describes aberrant #Sialylation as a critical driver of malignancy and #ImmuneSuppression, highlighting glycan-targeting strategies and sialyltransferase inhibitors as promising avenues for #PrecisionOncology.

#OpenAccess: doi.org/10.1016/j.ge...

Risk Factors and Predictive Nomogram for Survival in Elderly Patients with Brain Glioma

#Nomograms built from #SEER data identify age, marital status, histology, stage, treatment, and #tumor location as key prognostic factors in elderly #glioma, accurately predicting survival and aiding risk stratification for clinical decision-making.

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Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening

#Icariin ameliorates D-galactose-induced injury in neuron-like PC12 cells by blocking the abnormal mPTP opening, thereby suppressing #Autophagy, reducing #ROS generation, & mitigating #Apoptosis in a model of accelerated #Senescence.

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Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint: A Retrospective Analysis

#NeoadjuvantChemotherapy in #Osteosarcoma elevates #SerumLipids (TC, TG, ApoB, LDL-C, ApoE); pretreatment levels show no prognostic value, but rising Lp(a) correlates with Ki-67, hinting at a potential #biomarker for outcomes.

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This study identifies the #VickersLigament as a combination of the radiolunate and stretched TFCC ligaments, suggesting that focal growth retardation at the radius drives its formation in Madelung deformity.

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#BoneGrowth #PediatricOrthopaedics #ClinicalResearch

LncRNA MEG3 Inhibits the Epithelial-mesenchymal Transition of Bladder Cancer Cells through the Snail/E-cadherin Axis

MEG3, a #lncRNA, suppresses #EpithelialMesenchymalTransition in #BladderCancer by binding Snail to prevent #Ecadherin repression and inhibiting ERK/JNK/P38 signaling, reducing invasion and migration—highlighting its promise as a therapeutic target.

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High Hydrostatic Pressure Exacerbates Bladder Fibrosis through Activating Piezo1

High hydrostatic pressure exacerbates #BladderFibrosis by activating the mechanosensitive ion channel #Piezo1, thereby positioning Piezo1 as a potential #TherapeuticTarget for #BladderOutletObstruction.

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USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells

#USP19 promotes high glucose– and fatty acid–induced kidney cell dysfunction by stabilizing TAK1, driving #apoptosis, mitochondrial stress, and PINK1/Parkin pathway disruption, highlighting USP19–TAK1 signaling as a target for #DiabeticNephropathy.
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Prevalence and Risk Factors of Stroke in Inpatients with Type 2 Diabetes Mellitus in China

A cross-sectional study identified a 13.1% stroke prevalence among #Type2DiabetesMellitus Chinese patients, showing that age, #Hypertension, diabetic duration, and #DiabeticNephropathy are significant independent risk factors.
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Monocyte to High-density Lipoprotein Cholesterol Ratio as a Predictor of Nonalcoholic Fatty Liver Disease in Childhood Obesity

Higher monocyte to high-density lipoprotein cholesterol ratio (MHR) is an independent predictor of #NAFLD in children with #obesity, linking #inflammation to disease risk and highlighting MHR as a useful #marker for early detection and intervention.
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Research Progress on the Pathogenesis and Treatment of Neoatherosclerosis

This study identified that #COVID19 pandemic-related anxiety & depression significantly impaired warfarin adherence & safety in #HeartValveReplacement patients, highlighting the influence of mental health on anticoagulation outcomes.
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Research Progress on the Pathogenesis and Treatment of Neoatherosclerosis

This review defines #neoatherosclerosis as a distinct in-stent pathology driven by oxidized lipids and #VSMC foam cells, stressing endothelial injury, #inflammation, and need for strategies beyond #LDL reduction to prevent #restenosis. @2024_HUST #stent
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Soluble ST2: A Novel Biomarker for Diagnosis and Prognosis of Cardiovascular Disease

An overview of the biology and functions of sST2, its potential as a diagnostic & prognostic #Biomarker for different types of #CVDs and the limitations restricting its clinical translation. #HeartFailure #Myocarditis
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Comment on: Clinical Characteristics, Diagnosis, and Treatments for COVID-19

This commentary highlights #COVID19–related #ImmuneReconstitutionInflammatorySyndrome, outlining triggers, #biomarkers, and inflammatory mechanisms, and stressing early recognition with targeted immunomodulatory therapies for #ImmunocompromisedPatients.

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Transforming Adolescent Smiles: Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners

This report highlights how strategic use of #InvisibleAligners and adolescent growth potential can correct complex bimaxillary protrusion & mandibular retrognathia without mini-implants, ensuring optimal aesthetic results.
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Characteristics and Risk Factors for Pediatric Sepsis

Lower #hemoglobin, albumin, and platelet counts plus elevated IL-1β were identified as independent risk factors for poor prognosis in #PediatricSepsis, highlighting the need for early monitoring and timely intervention. #Inflammation

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Predictors of Adverse Pregnancy Outcomes Following Traumatic Injuries

This study identifies advanced maternal age, third-trimester gestation, and positive FAST scans as critical predictors of adverse pregnancy outcomes post-trauma, stressing the need to monitor these indicators to prevent such outcomes.

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Histological Features of Uterine Myometrial Dysfunction: Possible Involvement of Localized Inflammation

LPS-induced #UterineInflammation activates TLR4/NF-κB signaling, elevating #ProinflammatoryCytokines while suppressing Cx43 and #OxytocinReceptor expression, leading to myometrial dysfunction and #UterineAtony relevant to #PostpartumHemorrhage.
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Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis

This study establishes CDC20 as a #TherapeuticTarget in #EndometrialCarcinoma, showing that its inhibitor, #Apcin, suppresses proliferation and induces #Apoptosis & cell cycle arrest, by activating the BBC3/caspase-3 pathway & enhancing p21 expression.

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Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through the miR-652-3p/SOX4 Axis

Circ_0012152 is identified as an independent adverse #PrognosticFactor in #AcuteMyeloidLeukemia, with its upregulation promoting #leukemic cell growth and survival by sponging miR-652-3p to derepress #SOX4 and drive AML progression.

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TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway

A randomized clinical study demonstrates that the Jianpi Shengxue tablet effectively treats #RenalAnemia by significantly improving red blood cell counts, iron metabolism markers, and systemic symptoms compared to standard #IronTherapy. #Medsky

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TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway

TRPC6 knockout alleviates #RenalFibrosis by reducing fibrotic markers, #apoptosis, and #inflammation, while downregulating the PI3K/AKT/GSK3β pathway—supporting TRPC6 inhibition as a promising therapeutic strategy for #ChronicKidneyDisease.

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Crosstalk among Oxidative Stress, Autophagy, and Apoptosis in the Protective Effects of Ginsenoside Rb1 on Brain Microvascular Endothelial Cells: A Mixed Computational and Experimental Study

#Ginsenoside Rb1 protects BMECs from #Ischemia-reperfusion injury by regulating #Autophagy, #Apoptosis, and #OxidativeStress via SQSTM1/p62, ATG5, and HIF-1α, highlighting these as potential #TherapeuticTargets for #IschemicStroke.
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Therapeutic Effectiveness of Leukocyte- and Platelet-rich Fibrin for Diabetic Foot Ulcers: A Retrospective Study

Adding leukocyte- and platelet-rich fibrin to standard care significantly improved wound healing in #DiabeticFootUlcer patients, with faster early healing, high rates of epithelialization, and consistent benefits across severity grades. #DiabeticWound

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