Gerben de Zwaan

New paper from my team detailing a greatly expanded genomic database of Asgard archaea revealing of high energy metabolism those related to eukaryotes! Led by @katyappler.bsky.social lots of help from @jameslingford.bsky.social @valdeanda.bsky.social @kassipan.bsky.social doi.org/10.1038/s415...

Beyond thrilled to share that our study has been published!
This project encompasses years of work, including my thesis research on Asgard archaea in the @archaeal.bsky.social lab at @utmsi.bsky.social and
@texasscience.bsky.social!!!
#MicroSky #ArchaeaSky 1/12

Finally out in @nature.com: a new piece of the puzzle of how complex life evolved. Lead by @archaeal.bsky.social & @katyappler.bsky.social. Great collab with @greening.bsky.social and @kassipan.bsky.social. More pieces to follow soon! www.nature.com/articles/s41...

Two more weeks to apply - come join us () in The Netherlands as a postdoctoral researcher on large-scale metagenomic exploration of new lineages!

Today we published a Correction on our 2023 @nature.com paper reporting the heimdallarchaeial ancestry of eukaryotes: www.nature.com/articles/s41...

Corrected paper: www.nature.com/articles/s41...

Importantly, the re-analyses of the corrected dataset are consistent with the original findings.

We haven't really tried co-extractions but we have used the AllPrep PowerFecal kit for both DNA and RNA on sediments and it does work fine. The Powerfecal and Powersoil are generally almost identical. Our technicians also pointed out there is some small tricks in the handbook of the kit. Goodluck!

I finally got around to writing the discussion section of our lab's basic training course on live cell #microscopy. I explain the tradeoffs involved in designing an imaging experiment and the art of thinking of the experiment as an optimization problem.

leb-epfl.github.io/basic_traini...

Come join our group in the beautiful (currently very snowy) Wageningen!

I have a postdoc position in metagenomic exploration available in my group. Candidates with documented experience in phylo & metagenomics and preferably with petabase-scale data mining and GLM workflows are encouraged to apply. Come join us! 🧬🦠💻

Please repost

Apply here: www.wur.nl/en/vacancy/p...

Best of Luck @pieterhart.bsky.social and @danieltamarit.bsky.social, Super excited to see what you guys get up to together!

a man walking in a field with an umbrella ALT: a man walking in a field with an umbrella

Come join us! Soon I will be advertising a postdoc vacancy in my group as part of my @erc.europa.eu AdG project 'DARK ROOTS'. Focus of the project will be on phylo- and metagenomic mining of novel prokaryotic lineages. I will soon post a link here - stay tuned, and please repost! #asgardarchaea

That should work just fine, we've been close to 1ng/uL. Just keep in mind that you might miss some low abundant taxa.

We routinely use the DNeasy Qiagen Powersoil for sediment samples. In the past, together with a QiaCube(96 samples), but this struggled a lot with lower biomass samples. So we switched to the Qiagen EZ2, which only does 24 samples per time but the yields are a lot more similar to manual extractions.

Nutrient availability affects optimal growth strategy in predatory DPANN | mSystems The bacterial and archaeal domains each possess a major clade that appears to be predominantly host-associated (1–3). These two lineages, Patescibacteriota and DPANN archaea (named for the Diapherotri...

Ever since publishing our observations of the predatory behaviour of Ca. Nha. antarcticus people have asked me why it would want to kill its host. My perspective discussing the ecological factors that I believe led to this behaviour is out now in mSystems:
doi.org/10.1128/msystems.01475-25

Phylogenetic reconciliation supports a methanogenic ancestor of the Archaea and a derived origin for host-associated lineages The phylogeny of the Archaea continues to be revisited and revised as new groups are discovered and phylogenetic methods improve, but key questions about their early evolution remain. It has been sugg...

#Archaea, #DPANN, #phylogenetic_reconciliation
New preprint online!
www.biorxiv.org/content/10.1...

Opportunity!
Anybody knows of young marine ecologists (within 7 years from earned PhD) that would like to come to Gothenburg, Sweden, for a nationally funded Assistant Professorship? It is highly competitive but well funded. (1) of (3)

Soon available in my group: 1 PhD position to investigate prokaryotic histones. See our recent work that highlights the existence and diversity of prokaryotic histones (e.g. Schwab et al., TIBS, 2025; Schwab et al., Nat Comm, 2024; Hu et al., Nucl Acids Res, 2024). Please DM for informal enquiries.

🧙‍♀️ Something is brewing in the WitChi cauldron…
After some excellent peer review feedback, a new update of WitChi is taking shape, refining how we detect and prune compositional bias in phylogenomic alignments.

Stay tuned for the next release!

🧙‍♀️ Can’t model it? Prune it!
github.com/stephkoest/w...

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Congrats Dani! Well deserved!

I’m very happy this is finally out! Here, we showcase the combination of BONCAT and SIP metaproteomics to uncover rare and active microbes driving anaerobic acetate turnover. We are excited to see what other microbial metabolisms and ecosystems this approach can help to illuminate! 🦠

Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.

Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky

CDA-leider Bontenbal: religieus onderwijs mag botsen met grondrecht van gelijkheid Dat religieuze scholen homoseksuele relaties afwijzen, is volgens CDA-leider Henri Bontenbal nu eenmaal een gevolg van de vrijheid van onderwijs. Daar wil hij niet aan tornen. "Een andere mening doet ...

Nou nee, dat mag niet.

Een school moet een veilige plek zijn voor álle leerlingen. Dat staat ook in de wet. Het afwijzen van homoseksuele relaties geeft de boodschap dat iemand niet zichzelf mag zijn.

Dat mag niet én is ronduit schadelijk.

nos.nl/nieuwsuur/co...

Live Cell Imaging of Ca. Nha. antarcticus and Hrr. lacusprofundi using agarose pads This protocol is an adapted form of the protocol developed for imaging haloarchaea (Liao et al., 2021) and subsequently applied to co-cultures containing nanohaloarchaea and haloarchaea (Hamm et al., ...

Live cell imaging of Ca. Nha. antarcticus and Hrr. lacusprofundi using agarose pads. Protocol now live!
www.archaea.bio/protocols/li...

The genomic basis of symbiotic integration at University of Bath on FindAPhD.com PhD Project - The genomic basis of symbiotic integration at University of Bath, listed on FindAPhD.com

There's a PhD position now available with me in Bath, on the evolution of symbiosis. www.findaphd.com/phds/project.... The supervisory team also includes @anja1.bsky.social @phil-donoghue.bsky.social and others. NB, this is open both to UK-based students *and* to international students :)

Very nice documentary about the origins of complex life with my PhD advisor Berend Snel @binfutrecht.bsky.social!

That's awesome! Congrats Océane!

michael scott from the office is wearing a suit and tie and making a funny face . ALT: michael scott from the office is wearing a suit and tie and making a funny face .

OK, somebody should say it: the term 'one-stop-shop' has no place in academic research. Due to their diverse and exploratory nature, there is no single solution for scientific projects - else this would be routine research. RT if you agree, or feel free to argue otherwise below.

Coincidental and exciting! Anaerobic methanotrophic archaea (ANME) do like carbon monoxide - two independent studies showcasing CO metabolism across freshwater and marine ANME (ANME-2d and -2b).

ANME-2d: doi.org/10.1101/2025... (Welte lab)
ANME-2b: reposted (Orphan lab)

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!