Conceptually, selection of somatic mutations that increase clone fitness can predict therapeutic efficacy-BUT some mutations cause conflict between clone and organism. Thanks to our key UK collaborators David Savage, Peter Campbell, Matt Hoare, and contributors from @cri-utsw.bsky.social 8/8
12.07.2025 17:03 — 👍 1 🔁 0 💬 0 📌 0
Consistently, Tbx3 KO protected against, and overexpression worsened fatty liver. This is because Tbx3 KO resulted in more VLDL-triglyceride secretion, which moves lipids from the liver to the rest of the body. Consequently, mice suffered from high blood triglyceride levels. 7/8
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Loss of function TBX3 mutant clones expand in mice and humans with fatty livers. This suggests that these mutations protect hepatocytes from lipid-induced toxicity. 6/8
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JCI -
Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion
The second paper/concept is that some somatic mutations can appear to benefit the clone or organ, but have negative effects for the organism. Congrats to Greg Mannino on his first paper! 5/8 www.jci.org/articles/vie...
12.07.2025 17:03 — 👍 5 🔁 1 💬 1 📌 0
Consistently, liver-wide CIDEB inhibition was more protective against disease mechanisms that led to more clone expansion, suggesting that patients with more or larger CIDEB mutant clones might expect greater benefit from CIDEB inhibition. 4/8
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CIDEB mutant clones expand more in the context of some fatty liver diets, but not others. This suggests that CIDEB mutations are protective of hepatocytes, but to varying degrees depending on diet type or genetic cause of disease. 3/8
12.07.2025 17:03 — 👍 1 🔁 0 💬 1 📌 0
Introducing 2 new papers from my lab on somatic mutations in liver disease. The 1st is about a mutated gene that leads to improved clone fitness and organismal health (CIDEB). The 2nd is about a mutated gene that leads to improved clone fitness but worse overall health (TBX3). 1/8
12.07.2025 17:03 — 👍 11 🔁 5 💬 1 📌 1
Today's #thursdaymotivation is courtesy CRI's @haozhulab.bsky.social: Congrats Gianna Maggiore for your successful #dissertationdefense! Dr. Maggiore's family and lab mates joined to celebrate. Next steps: summertime fun & finishing her M.D. 🎉 #relentlessdiscovery
05.06.2025 20:44 — 👍 3 🔁 2 💬 0 📌 0
Naxerova lab at @HMSGenetics. We study somatic evolution and cancer genetics.
Evolutionary Biologist at Stanford. Rapid Evolution, Adaptation, and Genomics. Open Science advocate.
Johnson Chair/Assoc. Prof., Peds DevBio @ CU Anschutz:
#zebrafish, #devbio, heart disease, lateral plate mesoderm, #evodevo, imaging, transgenesis, et al.
#MobileOfficeViews | #AlwaysBeWriting | guitars | Colorado | #SwissAbroad 🧪
Not-for-profit publisher of Development, Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open. Host of community sites the Node, preLights and FocalPlane. Supporting biologists and inspiring biology.
All views and opinions expressed are my own.
Human biology and cancer therapeutics group @MSKCancerCenter
+ @WeillCornellGS + @TPCB_NYC + @TriIMDPhD | + a bit of @oleg8r | Views our own | https://alexkentsis.net
Professor at the NYU School of Medicine (https://yanailab.org/). Founder and Director of the Night Science Institute (https://night-science.org/). Co-host of the 'Night Science Podcast' https://podcasts.apple.com/us/podcast/night-science/id1563415749
The Vander Heiden Lab at the Koch Institute for Cancer Research at MIT studying how metabolism is altered to support inappropriate cancer cell proliferation. vanderheidenlab.mit.edu
Senior Editor @Nature for cancer and cell cycle. Views my own
Physician scientist at UTSW. T cell biologist geneticist dermatologist. Passionate about cancer and autoimmune disease. Co founder moonlight bio.
Chief Science and Strategy Officer, openRxiv. Co-Founder, bioRxiv and medRxiv.
We’re the world's leading independent cancer charity dedicated to saving lives through research, influence and information.
linktr.ee/cr_uk
Pediatric Hematologist/Oncologist, Geneticist, Stem Cell Biologist
bloodgenes.org
Postdoc in Ralph DeBerardinis' Lab and Neonatologist at UT Southwestern (UTSW) via Harvard/MIT MD-PhD, Harvard Pediatric Residency, UTSW Neonatology Fellowship | STAT Wunderkind, ASCI E-Gen Award, BWF CAMS
Studying #metabolism, #mitochondria, #peroxisomes
PhD @SNU, Postdoc @UCBerkeley, Assistant professor @UTSW CRI from Jan 2024. All about Lysosome. Cholesterol Metabolism. Cell biology
Executive Editor of Cancer Discovery, published by AACR. Harvard BBS/Dana-Farber alum. Native New Yorker. Posts are my own. She/her https://aacrjournals.org/cancerdiscovery
Oncologist-scientist at Weill Cornell and New York genome center. Into somatic evolution, trees and words
Director of Children's Research Institute at UT Southwestern (@cri_utsw.bsky.social) & Howard Hughes Medical Institute Investigator. My lab studies stem cells & cancer. I sit at a computer, grateful that I can "do" science. Views are mine. 🇨🇦🇺🇸
We are a community of researchers working together to answer fundamental questions about the biological basis of disease. #StemCells #CancerBiology #Metabolism
I still like small data but I'm not opposed to big data. We study #metabolism, #genetics, #pediatric inborn errors & cancer.
