Children's Research Institute at UT Southwestern

Happy Halloween 🎃
Scary: food in the lab (👋 Harrison)
Sweet: problem-solving lab managers, like Jessica!
🎃🍬🤍🦇🕷️🕸️🐈‍⬛💀🧡🐦‍⬛🕯️🖤‍🍂🍁🪾🔮🧪
@rjdlab.bsky.social

Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila | PNAS Recent work suggests that asymmetric segregation of preexisting and newly synthesized canonical histone 3.1 (H3.1), but not variant histone 3.3A (H...

ONLINE NOW: CRI's Ohlstein Lab presents new research that reevaluates whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila, in @pnas.org. Read more ⬇️ www.pnas.org/doi/10.1073/...
#relentlessdiscovery 🧪

From the trenches: Words of wisdom to postdocs from UTSW trailblazers - CT Plus - UT Southwestern Four distinguished UT Southwestern scientists who are members of the National Academies inspired postdoctoral researchers by sharing their own experiences as postdocs recently, offering words of encou...

📍 #MotivationMonday:
"Resilience isn’t something that you are born with – it is a set of skills you have to cultivate.” -@seanjmorrison.bsky.social

Read more about pushing through adversity & #relentlessdiscovery with Sean & @rjdlab.bsky.social ⬇️
www.utsouthwestern.edu/ctplus/stori...

Advances in Proteomics & Metabolomics 2025 Proteomics and metabolomics are unlocking new dimensions in our understanding of biology and disease. This event will highlight the latest developments in mass spectrometry, single-cell proteomics and...

Interested in organellar metabolomics? Check out my talk tomorrow on how the Rapid Organellar IP technology has enabled discoveries in organellar biology over the past 10 years! Ty Tech Networks for the invite! @cri-utsw.bsky.social @rjdlab.bsky.social www.technologynetworks.com/proteomics/o...

Many thanks also to @cri-utsw.bsky.social for providing such an excellent environment for training and discovery.

Congrats to all Damon Runyon's SPARK Scholars, including our own scholar Imani Williams who is studying cancer metabolism. Thank you Damon Runyon Cancer Research Foundation @damonrunyon.org for supporting this great initiative.
www.damonrunyon.org/news/entries...

Thrilled to announce the launch of my lab
@cri-utsw.bsky.social at UTSW this January!

We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.

We're growing! Our newest Investigator @henrydebelly.bsky.social will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henr... and 📌apply to research in his lab cri.utsw.edu/careers

One week left to apply!

Excited to present my research at the upcoming University of Utah Rising Stars Symposium and meet fellow scientists who love metabolism! @cri-utsw.bsky.social @rjdlab.bsky.social

Thank you @cri-utsw.bsky.social postdocs!

We have the best postdocs! We appreciate you being a critical part of our CRI team to help discover the treatments of tomorrow. #npaw2025 #npaw #relentlessdiscovery 🧪

UTSW named Specialized Program of Research Excellence for liver cancer The Liver Tumor Program at UT Southwestern Medical Center’s Harold C. Simmons Comprehensive Cancer Center has been selected by the National Cancer Institute as a Specialized Program of Research Excell...

🎉 JUST ANNOUNCED: @haozhulab.bsky.social named project co-leader for UTSW liver cancer SPORE. His project will study how to prevent hepatocellular carcinoma — which accounts for >85% of liver cancer cases across the nation.
Read more ⬇️ cri.utsw.edu/zhu-named-co...
#relentlessdiscovery 🧪

🔬 APPLY NOW: Seeking faculty scientists in #stemcells #TissueRegeneration #metabolism & #cancerbiology.

You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛

#jobs #faculty #facultyjobs #ScienceJobs 🧪

Excited to join the @cri-utsw.bsky.social community to advance discoveries in genome instability. We are grateful to UTSW Pathology for 6 wonderful years.

🚨 We are also recruiting motivated postdocs to study how mitotic errors and aberrant nuclear structures drive cancer genome evolution—join us!

WELCOME to the Institute, @peterlylab.bsky.social! Dr. Ly studies how cells maintain genomic integrity and how dysregulation of these processes impacts human health. 🧪Learn more about his research 👉 cri.utsw.edu/faculty/pete... #relentlessdiscovery

👉New article in @newscientist.com features a #relentlessdiscovery 🧪 from CRI's Agathocleous Lab ⬇️

Thrilled and deeply honored to be named a 2025 Pew Biomedical Scholar!
Huge congrats to my friend and colleague
@cri-utsw.bsky.social Javi, who’s also joining the Pew family as a Pew-Stewart Scholar.
CRI is on fire—let’s go make some bold, groundbreaking science happen! 🔥🧪✨

🎉 Huge congrats to Drs. Javier García-Bermudez and @hrshin.bsky.social for being named Pew-Stewart & Pew Scholars! Well-deserved recognition for two outstanding @cri-utsw.bsky.social scientists!

Two Children’s Research Institute scientists named 2025 Pew Scholars - Children's Medical Center Research Institute (CRI) | Dallas Texas Javier Garcia-Bermudez, Ph.D., Hijai Regina Shin, Ph.D., selected to advance cancer, biomedical research DALLAS – Aug. 12, 2025 – Two Children’s Medical Center Research Institute at UT Southwestern fa...

Congrats! 👏👏👏 Two CRI scientists named 2025 Pew-Stewart & Pew Scholars — Javier Garcia-Bermudez, Ph.D. &
@hrshin.bsky.social — to advance cancer, biomedical research 🧪 Read more about their #relentlessdiscovery ⬇️ cri.utsw.edu/two-children... @pewtrusts.org

Chemoprevention for hepatocellular carcinoma using GalNAc-siRNAs The ability to prevent hepatocellular carcinoma (HCC) in patients with chronic liver disease remains an unmet clinical need. We performed a head-to-head comparison of GalNAc-conjugated siRNA mediated ...

ONLINE NOW in @biologists.bsky.social "Disease Models & Mechanisms:" from CRI's @haozhulab.bsky.social about siRNAs for liver cancer prevention ⬇️ read more #relentlessdiscovery 🧪
journals.biologists.com/dmm/article/...

Pieces of the peroxisomal import puzzle - Nature Cell Biology Peroxisomes are single membrane-bound organelles containing numerous enzymes to perform metabolic functions. However, our view of peroxisomal protein import has remained incomplete. Two recent studies...

Big thanks to Jianguo Wu, Min Zhuang, @natcellbio.nature.com for a great News and Views on our work and that of Michael Skowyra, Tom Rapoport.

www.nature.com/articles/s41...

PEX39 facilitates the peroxisomal import of PTS2-containing proteins - Nature Cell Biology Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the im...

1/New paper on peroxisome assembly, reporting the detailed mechanism of PEX39, a new peroxin involved in PTS2 protein transport. Fantastic work by ‪@walterwchen.bsky.social‬ and a dream team of collaborators, as explained below. www.nature.com/articles/s41...

🧵⬇️ @walterwchen.bsky.social
#relentlessdiscovery 🧪

DeBerardinis Lab discovers first human peroxin in 20 years - Children's Medical Center Research Institute (CRI) | Dallas Texas CRI researchers, international colleagues identify PEX39, which facilitates peroxisomal protein import PEX39 is the first new human peroxisomal biogenesis protein, a peroxin or PEX, to be identified i...

ONLINE NOW in @natcellbio.nature.com: CRI's @rjdlab.bsky.social Lab postdoc @walterwchen.bsky.social & international colleagues have discovered the first new human peroxin in 20 years. Read more ⬇️ cri.utsw.edu/deberardinis... #relentlessdiscovery 🧪

ONLINE NOW in @nature.com: latest research from CRI's @rjdlab.bsky.social Lab, full 🧵⬇️
#relentlessdiscovery 🧪

👏👏👏 Congrats to CRI grad student researcher Dylan Calhoon! He'll be presenting about the most recent #relentlessdiscovery from the Garcia-Bermudez Lab. 🧪

ONLINE NOW: 2 new somatic mutation studies🧪 in #liver disease from CRI's @haozhulab.bsky.social
🟠 @jhepatology.bsky.social w/ postdoc Qiyu Zeng, Ph.D.
www.journal-of-hepatology.eu/article/S016...
🟠 @jclinical-invest.bsky.social w/ grad student Greg Mannino
www.jci.org/articles/vie...
⬇️Hao's thread🧵

Excited to receive an NIH K08 Clinical Investigator Award to support my research on #mitochondria #peroxisomes 😀 The $775K will be critical in helping me transition to independence as I begin looking for a place to start my lab 🙏🏻 @the-asci.bsky.social

An unexpected career in cancer metabolism Nature Cancer - Ralph DeBerardinis obtained an MD and PhD from the University of Pennsylvania, then trained in Pediatrics and Medical Genetics at Children’s Hospital of Philadelphia. He moved...

Thanks Nature Cancer for the chance to reflect on some factors that led me to study cancer metabolism. For the trainees and other young scientists: the critical events that shape your career might not be obvious while they are happening. Keep an open mind and trust your instincts.

rdcu.be/evi4I