Pooja Middha's Avatar

Pooja Middha

@poojamiddha.bsky.social

Genetic and Cancer Epidemiologist | Scientist at @RegeneronDNA | Alum @UCSFCancer, @dkfz, @UniHeidelberg, @umichsph | Views are my own ๐Ÿ‡ฎ๐Ÿ‡ณ๐Ÿ‡ฉ๐Ÿ‡ช๐Ÿ‡บ๐Ÿ‡ธ

175 Followers  |  286 Following  |  5 Posts  |  Joined: 03.10.2023  |  1.805

Latest posts by poojamiddha.bsky.social on Bluesky

Post image

Come check out our poster tomorrow on whole-exome sequencing of colitis adverse events in patients treated with immune checkpoint inhibitors #AACR25

@ucsfcancer.bsky.social
@mskcancercenter.bsky.social

28.04.2025 02:11 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events Introduction Immune checkpoint inhibitors (ICIs) can yield remarkable clinical responses in subsets of patients with solid tumors, but they also commonly cause immune-related adverse events (irAEs). T...

Thrilled to share our work on investigating the role of a polygenic risk score for overall autoimmunity in cessation of immune checkpoint inhibitor therapy for toxicities. bit.ly/3E3NkoX

@adamjschoenfeld.bsky.social
@ucsfcancer.bsky.social
@ucsfmedicine.bsky.social
@mskcancercenter.bsky.social

03.04.2025 20:18 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Excited to share our latest work exploring the role of germline genetics in the development of multiple primary cancers

@lindakachuri.bsky.social @jovia-n.bsky.social @johnwitte.bsky.social

06.02.2025 18:30 โ€” ๐Ÿ‘ 8    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Work by PhD student @jayatirsharma.bsky.social on how grouping Hispanic/Latino participants into a single group can obfuscate substantial substructure, leading to false conclusions.

We show how heterogeneity by background group wrt genetic ancestry and environment can affect genetic risk models.

02.12.2024 19:09 โ€” ๐Ÿ‘ 23    ๐Ÿ” 9    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival - Nature Communications Glioma is an aggressive brain tumor subtype with few known risk factors. Here, the authors utilise Mendelian Randomisation to investigate correlation of immune cell counts with subtype-specific risk a...

This paper was a long time coming, happy to see it out today in @naturecomms.bsky.social: www.nature.com/articles/s41...
We found some interesting links between genetic regulation of blood cell traits and #glioma risk + survival, pointing to #immune related mechanisms ๐Ÿง ๐Ÿงฌ

14.01.2025 19:25 โ€” ๐Ÿ‘ 8    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
YIC_position openings

As incoming chair of the young investigator committee of the International Genetic Epidemiology Society (IGES), I'd like to share a great opportunity for 5 Early Career Researchers to join the different IGES committees, deadline 31st Dec, details here: www.geneticepi.org/yic_position...

05.12.2024 15:06 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Post image Post image Post image

One of the most important multi-cancer analyses on #ImmuneRelatedAdverseEvent grading and clinical outcome is out this week from @JNCI : https://buff.ly/499OIBj

26.11.2024 03:54 โ€” ๐Ÿ‘ 9    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 3

These people made it all possible: @supportingswog.bsky.social

26.11.2024 04:24 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
Preview
What is Machine Learning? A Primer for the Epidemiologist Abstract. Machine learning is a branch of computer science that has the potential to transform epidemiologic sciences. Amid a growing focus on โ€œBig Data,โ€

academic.oup.com/aje/article/...

#episky #statsky #epidemiology #statistics

21.11.2024 21:24 โ€” ๐Ÿ‘ 44    ๐Ÿ” 4    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 0
Post image Post image Post image Post image

๐ŸŽจ In case anyone needโ€ฆ

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool ๐Ÿ™!

Check it out ๐Ÿ‘‡
bioart.niaid.nih.gov

23.11.2024 15:49 โ€” ๐Ÿ‘ 1207    ๐Ÿ” 494    ๐Ÿ’ฌ 44    ๐Ÿ“Œ 28
Post image

In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox:
For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?

22.11.2024 16:45 โ€” ๐Ÿ‘ 162    ๐Ÿ” 73    ๐Ÿ’ฌ 8    ๐Ÿ“Œ 4

Here we demonstrate the potential clinical utility of a polygenic risk score of ulcerative colitis to identify individuals at high risk of developing immune checkpoint inhibitor-mediated colitis, particularly severe colitis.

27.03.2024 18:31 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Preview
Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis - Nature Communications Colitis is one of the most common immune-related adverse events in patients with cancer treated with immune checkpoint inhibitors. Here the authors show that a polygenic risk score for ulcerative coli...

Thrilled to see our work on genetic prediction of immune checkpoint inhibitor-mediated colitis published

t.co/nsCV47ahwl

27.03.2024 18:30 โ€” ๐Ÿ‘ 13    ๐Ÿ” 5    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Preview
Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric d... A multivariate framework for isoform-resolution transcriptome-wide association studies enables modeling of a greater number of genes, with the benefit of identifying isoform-specific associations with...

Our isoTWAS work with the Pasaniuc and Gandal labs is out at Nature Genetics! Great team effort, especially from Daniel Vo and Connor Jops. Appreciate the helpful and thoughtful comments from reviewers that improved our work!

www.nature.com/articles/s41...

30.11.2023 16:19 โ€” ๐Ÿ‘ 9    ๐Ÿ” 4    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
Post image

I'm writing a molecular perspective on heritability, behavior, (and eventually) race/ancestry, group differences. The idea is to start with what we've learned from genetic data and then work backwards to what we used to know from classical studies. gusevlab.org/projects/hsq/

31.10.2023 17:45 โ€” ๐Ÿ‘ 35    ๐Ÿ” 16    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 1

Weโ€™re back with a bigger and better GWAS of PSA levels! ๐Ÿคฉ We substantially increased sample size in African ancestry (+58k) and Hispanic/Latino (+23k) men, which translates into meaningful improvements in PRS performance

www.medrxiv.org/content/10.1...

31.10.2023 17:59 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Trying to be better with sharing work on here ๐Ÿ˜…
Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment ๐Ÿงฌ ๐Ÿง 

16.10.2023 17:51 โ€” ๐Ÿ‘ 6    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

@poojamiddha is following 20 prominent accounts