Patrick MacDonald🇨🇦

(🧵1/23) First month of 2026: complete✅! Many papers coming from CIRTN scientists, including works from the labs of Drs Bruin, Lynn, Estall, Ferdaoussi, Fullerton, Hull-Meichle, Pepper, Korbutt, Levings, Lim, Mulvihill, Rabasa-Lhoret, Riddell, Rutter, Tsai, Woo and Verchere! 📝

After the World Trade Center was attacked (just four miles from Trump Tower), more than 40,000 Canadians in uniform fought alongside their U.S. allies in Afghanistan.

More than 2,000 Canadians were wounded.

These 158 didn't make it home.

And now this guy is giving lectures on gratitude.

Take a look behinds the sciences of our recent work!

Behind the Scenes: Featuring authors Theodore dos Santos, Xiao-Qing Dai, Patrick E. MacDonald, James G. Lyon, Aliya F. Spigelman, Nancy Smith, Tina Dafoe, and Austin Bautista and their work with IsletCore

What can surviving pancreatic cells tell us about type 1 diabetes?

Patrick E. MacDonald @bcellorg.bsky.social analyze pancreatic islet cells from donors with type 1 diabetes, defining pathways and mechanisms responsible for altered insulin and glucagon: doi.org/10.1172/JCI1...

Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes @jci.org @bcellorg.bsky.social @ualberta.bsky.social #T1D
www.jci.org/articles/vie...
www.jci.org/articles/vie...

An integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of #islet cells from #T1D donors highlights the importance of α cell dysfunction @albertadiabetes.bsky.social @jci.org @bcellorg.bsky.social www.jci.org/articles/vie...

YouTube video by CIRTN-R2FIC #1 Islets in a Pod with Dr. Patrick MacDonald

CIRTN-R2FIC is currently running in Toronto its 4th Annual Meeting. During this meeting we have launched our mini interview series called "Islets in a Pod" ! Our first interview is with Dr. Patrick MacDonald from the University of Alberta.
youtu.be/UlHn_1Fz3ck?...

It was a pleasure to attend the @cirtn.bsky.social workshop. I could not be more impressed by the incredible trainee presentations. And it was a special pleasure to present the first CIRTN Science Communication Award to three amazing scientists: Lahari Basu, Maria Galipeau and Cassandra Locatelli!

Unfortunately can’t be there in person this year, but wishing everyone attending @cirtn.bsky.social national meeting a good time in Toronto!

🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.

'Icicle kick' goes viral: CPL final tops 1 billion views

https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/0b881bb4-068b-47e1-aa08-df6969c9f628

Canada Is About to Lose Its Status as Having Eliminated Measles

“The New York Times found that at critical points, as measles was gaining new footholds in Canada, provincial politicians stopped public health officials from speaking out about the value of getting vaccinated”

www.nytimes.com/2025/11/06/w...

Robert Munsch has donated his personal archives of stories and materials to the Guelph Public Library.

This is wonderful for such a valuable archive to be given to a public municipal library.

www.guelphpl.ca/Modules/News...

YouTube video by Higher Education Strategy Associates Canadian Federal Budget 2025 Part 1

Budget analysis part 1

https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/ETWOFKPB7NGPPBFFEGKRNIBLAU

How much are MPs entitled to know about research grants? Not as much as you think. - Globe and Mail

🧵(1/4) We have finished up October 2025 🎃, and the CIRTN groups had several more publications coming from the labs of Drs Rennian Wang, Megan Levings and Marc Prentki.

This! Fancy web interfaces let you explore the data, but they are not the same as sharing the data. You can do both!

Open Letter to Protect Tri-Council EDI Data Why do we need urgent action to protect our data? The mandate of the House of Commons Standing Committee on Science and Research is to review and report on topics relating to science and research in ...

If you are a Canadian scientist interested in the protection of identifying information about applicants and reviewers of tricouncil grants please read and sign this letter. Thank you. docs.google.com/forms/d/e/1F...

📢 Support Our Science in the news!

We’re proud to be featured in CTV News’ latest story on Canada’s emerging “brain gain” — a scientific migration as researchers look north amid challenges in the U.S.

Doesn’t EGA have a node in Sweden specifically for controlled access sharing of this type of data?

https://fega.nbis.se

Interesting paper, but does anyone know if the claim that “…The datasets (genome-wide raw sequencing and individual-level clinical data) … are not publicly available due to EU and national legislation” is reasonable?

https://www.nature.com/articles/s41598-025-21595-1

🧵(1/4) For the first half of October 2025 we have 3 publications from the CIRTN labs🍁. These papers are from the groups of Drs. Bruce Verchere, Yi-Chun Chen, Francis Lynn, James Shapiro, Tatsuya Kin and Guy Rutter!

Today, #ForeverCanadian brought 230,000 petition signatures to Edmonton. Our volunteers will continue collecting signatures until October 28. We need your signature to reach our 300,000 requirement to keep Alberta in Canada.

#ableg #Yeg #Yyc #CdnPoli

🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!

Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...

And a special thank you to the organ donors, and organ procurement organizations and coordinators across the country (BC Transplant, Alberta Health Services / Give Life Alberta, Ontario Health / TGLN, Quebec Transplant, MOTP Atlantic Canada).

Over the past, nearly 15 years, our team has isolated more than 140 million pancreatic islets in support of diabetes and transplantation research across three continents.