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sofie.rec

@sofie-dot-rec.bsky.social

Sofie van Dorst | PhD student @Biozentrum looking at green bugs under the microscope #TeamTomo

515 Followers  |  342 Following  |  7 Posts  |  Joined: 14.11.2024  |  2.0411

Latest posts by sofie-dot-rec.bsky.social on Bluesky

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Long in the making, but happy to present the Chlamydomonas chlororibosome!
Cryo-ETπŸ”¬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins.
bioRxiv πŸ“–: shorturl.at/q44tG
This suggests greater chlororibosome diversity than expected!
1/n 🧡

10.02.2026 08:35 β€” πŸ‘ 87    πŸ” 29    πŸ’¬ 2    πŸ“Œ 5
Hot Topic Conference Support for an "Eduard Strasburger Hot Topic Conference" for DBG's members

For #ECR’s:

DBG’s Hot Tpoic Workshop
on Cryo-Electron Tomography + FIB-milling

13 – 15 April 2026
In @cellarchlab.com 's lab @biozentrum.unibas.ch

Organised by @tamb-o.bsky.social, Karen Zinzius, @fannyleblanc.bsky.social

Details: www.deutsche-botanische-gesellschaft.de/en/about-us/...

03.02.2026 17:24 β€” πŸ‘ 11    πŸ” 9    πŸ’¬ 0    πŸ“Œ 0

You like #LLPS? #TeamTomo? #Rubisco? Check out our latest preprint!

What a great collaboration this has been!

30.01.2026 15:38 β€” πŸ‘ 30    πŸ” 11    πŸ’¬ 0    πŸ“Œ 0

Excited to share this detailed biophysical study of #PhaseSeparation in the Pyrenoid, an algal microcompartment that fixes a third of the Earth's #CO2 🌏. We combine methods across scales, in vitro πŸ§ͺ and in vivo 🦠

Thanks for the very fun collaboration! πŸ€—
#PlantScience 🌾 #TeamTomo πŸ”¬ #LivingPhysics 🧬🧢

30.01.2026 15:50 β€” πŸ‘ 63    πŸ” 18    πŸ’¬ 1    πŸ“Œ 1

Check out this cool thread on the latest preprint by Gaurav Kumar, @james-r-barrett.bsky.social, @phaips.vd.st from our lab and colleagues, dissecting the physics of Rubisco condensates!

You're in for some stunning #cryoET of the pyrenoid - in Chlamy, of course πŸ˜‰

Congrats to all involved!

30.01.2026 15:54 β€” πŸ‘ 18    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algaeβ€”the pyrenoidβ€”to find out… 🧡

Preprint here!:
www.biorxiv.org/content/10.6...

@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid

30.01.2026 15:20 β€” πŸ‘ 74    πŸ” 34    πŸ’¬ 1    πŸ“Œ 5

πŸ”¬πŸš¨New preprint alert! πŸš¨πŸ”¬

We developed quantitative expansion microscopy (qExM) - a method to accurately count proteins in situ by combining expansion microscopy's improved labeling with statistical estimators borrowed from ecology

www.biorxiv.org/content/10.6...

#SuperResolution #CellBiology

20.01.2026 16:12 β€” πŸ‘ 44    πŸ” 18    πŸ’¬ 5    πŸ“Œ 1
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a woman says " would you like to join us " with her eyes closed ALT: a woman says " would you like to join us " with her eyes closed

πŸ“’ Open faculty position – Origins of Life
We have an opening in our section at the University of Geneva! πŸ§¬πŸš€

SPREAD THE WORD

Apply here: jobs.unige.ch/www/wd_porta...

16.01.2026 17:49 β€” πŸ‘ 45    πŸ” 39    πŸ’¬ 1    πŸ“Œ 1
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The latest issue is now online www.cell.com/molecular-ce...

08.01.2026 16:59 β€” πŸ‘ 19    πŸ” 7    πŸ’¬ 0    πŸ“Œ 2
ScienceDirect.com | Science, health and medical journals, full text articles and books.

Happy to see this out πŸ₯³

authors.elsevier.com/sd/article/S...

#TeamTomo #CryoET #CryoEM

19.12.2025 16:13 β€” πŸ‘ 16    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
Welcome to TomoGuide A step-by-step Cryo-ET guide

If you want to learn how to process cryo-ET data using the Chlamy dataset don't forget to check : tomoguide.github.io
@phaips.vd.st

19.12.2025 16:45 β€” πŸ‘ 15    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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a man walking in a field with an umbrella ALT: a man walking in a field with an umbrella

Come join us! Soon I will be advertising a postdoc vacancy in my group as part of my @erc.europa.eu AdG project 'DARK ROOTS'. Focus of the project will be on phylo- and metagenomic mining of novel prokaryotic lineages. I will soon post a link here - stay tuned, and please repost! #asgardarchaea

26.11.2025 15:39 β€” πŸ‘ 33    πŸ” 33    πŸ’¬ 0    πŸ“Œ 2
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Schmidt Ocean Our Purpose: to excite interest and inform the wise stewardship of our planet. Our Mission: Catalyze the discoveries needed to understand our ocean, sustain life, and ensure the health of our planet ...

Starting at 7pm Central I will be streaming from the bottom of the ocean off the coast of Uruguay!

Feel free to join and ask questions.

www.youtube.com/@SchmidtOcean

14.11.2025 19:39 β€” πŸ‘ 17    πŸ” 10    πŸ’¬ 1    πŸ“Œ 1
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An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von KΓΌgelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

07.11.2025 10:44 β€” πŸ‘ 387    πŸ” 170    πŸ’¬ 10    πŸ“Œ 22
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33 million euro investment for national electron microscope facility EMPower A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...

Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...

04.11.2025 07:14 β€” πŸ‘ 78    πŸ” 17    πŸ’¬ 6    πŸ“Œ 7
33 million euro investment for national electron microscope facility EMPower A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...

Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! πŸ‡³πŸ‡±πŸ”¬

Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! 🦠

www.uu.nl/en/news/33-m...

03.11.2025 16:47 β€” πŸ‘ 91    πŸ” 14    πŸ’¬ 4    πŸ“Œ 1
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We’re back with the next DinoSphere Online Seminar!

Join us on Nov 4th, we're hosting:

Edmée Royen (ULiège) - Symbiodinium

Nicolas dos Santos Pacheco (Cambridge) - Perkinsids

πŸ“… Tue, Nov 4 - 4 PM CET/3 PM GMT
β€¨πŸ’» Zoom link: sites.google.com/view/dinosphere


Please spread the word!
#protistonsky

28.10.2025 15:29 β€” πŸ‘ 19    πŸ” 16    πŸ’¬ 0    πŸ“Œ 2
Fig. 2.Confocal microscopy of N. punctiforme strains. Filaments from the indicated strains were taken from cultures grown in BG110 medium (not induced; A) or after incubation for 24β€…h in the presence of Anthoceros agrestis exudates (hormogonia induction; B) and visualized by confocal microscopy. Merged (2 channels) show the overlay of autofluorescence (magenta) and GFP fluorescence (green). Merged (3 channels) represent the overlay of magenta autofluorescence, bright field, and green GFP fluorescence. Hormogonia are identified as short filaments with small cells. Scale bar=20β€…ΞΌm.

Fig. 2.Confocal microscopy of N. punctiforme strains. Filaments from the indicated strains were taken from cultures grown in BG110 medium (not induced; A) or after incubation for 24β€…h in the presence of Anthoceros agrestis exudates (hormogonia induction; B) and visualized by confocal microscopy. Merged (2 channels) show the overlay of autofluorescence (magenta) and GFP fluorescence (green). Merged (3 channels) represent the overlay of magenta autofluorescence, bright field, and green GFP fluorescence. Hormogonia are identified as short filaments with small cells. Scale bar=20β€…ΞΌm.

πŸ’‘πŸ”¬ TECHNICAL INNOVATION πŸ’‘πŸ”¬

Neubauer et al. developed a Nostoc reporter strain enabling high-throughput quantitative monitoring of hormogonia differentiation in cyanobacteria as a response to biotic and abiotic factors.

πŸ”— doi.org/10.1093/jxb/...

#PlantScience πŸ§ͺ @peterszovenyi.bsky.social

24.09.2025 11:31 β€” πŸ‘ 9    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

πŸ₯¨πŸ”¬!

23.09.2025 17:31 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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🌱 Using β€˜compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn

20.09.2025 13:59 β€” πŸ‘ 68    πŸ” 18    πŸ’¬ 3    πŸ“Œ 7
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Flagellar gliding in choanoflagellates Freire-Delgado and Brunet discover a new mode of cell motility in choanoflagellates, the closest relatives of animals. Under mild confinement, choanoflagellate move over surfaces without cell deformat...

New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧡

09.09.2025 18:11 β€” πŸ‘ 209    πŸ” 86    πŸ’¬ 7    πŸ“Œ 7

A new #UExM probe for #Actin!

Fun times thinking/developing/testing with @centriolelab.bsky.social & @lreymond.bsky.social !

Congrats to all !

If interested in #UExM, or #HAK-Actin, feel free to reach out !

Soon available at @spirochrome.com

#Expansion #Microscopy #ProtistsOnSky

28.08.2025 07:16 β€” πŸ‘ 45    πŸ” 19    πŸ’¬ 3    πŸ“Œ 0
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An Asgard archaeon from a modern analog of ancient microbial mats It has been proposed that eukaryotic cells evolved via symbiosis between sulfate-reducing bacteria and hydrogen-producing archaea. Here we describe a highly enriched culture of a novel Asgard archaeon...

Our new preprint with a new #Asgard from stromatolites (and its Desulfobacterota companion). Complete circularised genomes of both, cool #cryoem images, protein modelling, etc

Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...

23.07.2025 08:48 β€” πŸ‘ 50    πŸ” 20    πŸ’¬ 5    πŸ“Œ 3
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Characterizing organisms from three domains of life with universal primers from throughout the global ocean - Scientific Data Scientific Data - Characterizing organisms from three domains of life with universal primers from throughout the global ocean

Please Re-Post. Our global GRUMP microbial ocean database is out in Scientific Data! Unfractionated, single universal PCR, with Archaea, Bacteria, and Eukaryotes all on the same scale with the same denominator. Pole to pole, depths to 6000m. Lots of metadata. www.nature.com/articles/s41...

02.07.2025 16:19 β€” πŸ‘ 45    πŸ” 31    πŸ’¬ 2    πŸ“Œ 2
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After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!πŸ”¬β„οΈ tinyurl.com/2rdu2ze6

27.06.2025 10:58 β€” πŸ‘ 159    πŸ” 45    πŸ’¬ 9    πŸ“Œ 5
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Excited to share the lab's 1rst preprint! Rapid high-res immunofluorescence is now possible in cultured & environmental diatoms thanks to 4-fold expansion microscopy. A step-change for comparative cell biology in one of the most important phytoplankton groups on the planet πŸ₯³
tinyurl.com/m9s5su7s 1/2

17.06.2025 07:33 β€” πŸ‘ 323    πŸ” 89    πŸ’¬ 8    πŸ“Œ 19

Final PhD paper now reviewed and published in JSB:X. I was happy with some great reviews that improved the paper! Thanks to Sander Roet for his help with the code base, and Remco Veltkamp and @fridof.bsky.social

09.06.2025 06:56 β€” πŸ‘ 20    πŸ” 4    πŸ’¬ 0    πŸ“Œ 1

Are you a recent dinoflagellate convert, or already long dedicated to the craft? Don't you wish you could talk about them more?

Join Manon's DinoSphere seminar series! All things phylogeny, imaging, ultrastructure and more :)

#protistsonsky

04.06.2025 05:52 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Unicore identifies single-copy protein structures across genomes using Foldseek, bypassing slow structure predictions by utilizing 3Di predictions from ProstT5, enabling rapid phylogenetic inference at the tree-of-life scale. 1/n
πŸ“„ www.biorxiv.org/content/10.1...
πŸ’Ύ github.com/steineggerla...

23.12.2024 16:39 β€” πŸ‘ 121    πŸ” 57    πŸ’¬ 2    πŸ“Œ 3

Anti-gatekeeping workflows is what keeps #teamtomo growing! Love to see it.

07.05.2025 15:16 β€” πŸ‘ 13    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

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