Misha Kudryashev

Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇

For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!

www.mdc-berlin.de/postdocs#t-g...

Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ...
Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus
biorxiv.org/content/10.1...

Thanks Mimi! ❄️❄️❄️

Thanks Sandip!

Thanks John !!!

We have a preprint for you

EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer

By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...

It's fellowship season in the EU. If you want to talk and join our group at the amazing MDC in Berlin on a fellowship, please write me an email.

We do cryo-EM/ET, membrane proteins, data science/AI, our work: scholar.google.com/citations?so...

Fellowships: Marie Curie, EMBO, HFSP, Humboldt...

Our contribution to Mohit Misra, Ivan Đikić, and Co's stellar research on how a pathogenic bacterium, Legionella pneumophila, hijacks host cell signaling

It was a huge effort and took many years to combine all the data and methods, so enjoy reading👇
www.researchsquare.com/article/rs-6...

I think that it is not compatible with Krios 5

yeah, its very sad that Thermo makes older devices non-compatible.

Thanks!

Thanks !

Cool thanks Paulo. Any pros cons on arctis vs hydra ?

Cool thanks Katie, we have a similar experience in house. It's a great working horse 🐴🐴🐴

Hydra does look good on paper. Anything that could be improved in it ?

Thanks ! Cool. Are you happy with the milling throughput ?

Hi Cryo-EM fellas!

What are the pros and cons of the latest cryoFIB milling tools? Any usage experience with Arctis already? Any huge advantages of plasma?

Haha thanks !!! Text if you know someone!!

A broad call for a PhD researcher/ postdoc in our group at the MDC in Berlin. An ideal PhD student - a computational scientist, a postdoc - a structural biologist, but feel free to re-convince me!

We extended the deadline for after Easter, Apr 24th. Apply here www.mdc-berlin.de/career/jobs/...

Sooo, does anyone know the actual specs of the newly announced Thermo Fischer Krios G5?

Marketing material is wonderful, but what does it actually do ? 😁

PhD /Postdoc in In Situ Structural Biology by Cryo-ET Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin.

It's a broad call, please apply and share!
jobrxiv.org/job/max-delb...

English version of the documentary about power abuse in the Max Planck Society can be found here. 144.000 views already, more than 800 comments. Share it to make colleagues aware of what happens in German academia & the MPG! #IchBinHanna #PowerAbuse

Structure and topography of the synaptic V-ATPase–synaptophysin complex - Nature Using cryo-electron tomography and single-particle cryo-electron microscopy of functional synaptic vesicles, a V-ATPase–synaptophysin interface was found to regulate synaptic vesicle biogenesis and al...

Thanks Andrew! this is a beautiful paper from @johnrubinstein.bsky.social, they are much better in getting high res structures! We posted preprints roughly at the same time and it took us a bit longer to publish, their paper came out first along with: www.nature.com/articles/s41...

look at this, its a really amazing preprint from Jana @janakroll.bsky.social and Co!

They would have told you but it's against GDPR !!

MSCA awards €417 million to postdoctoral researchers 1696 outstanding postdoctoral researchers were selected for funding among 10,360 applicants.

Two (!!!) postdocs got Marie Curie fellowships to work in our group. Igor Silva who is already with us scored top 3% of the applications, amazing

We need to increase funding nationally and at the EU level to attract more great scientists

marie-sklodowska-curie-actions.ec.europa.eu/news/msca-aw...

😍❄️🔬🥬

Thanks Michaela and Hallo World! :)

Excellent perspective Juan!
technically many packages are open-source, such as tomoBEAR!

thanks! I am happy that you liked it! You have also been there probably with some vintage microscopes !?

Take a look at my personal perspective on the past, present, and future of in situ structural biology with cryo-ET+

While initially skeptical about the genre, I found it fun to write and hopefully, you can enjoy my experiences and some thoughts. Nice weekend y'all

www.cambridge.org/core/journal...