Will Oldham

#PVRI2026 was incredible! Got to catch up with friends & colleagues, hear exciting science, share our own (PAEC biopsies & systems pharmacology for precision PAH care) and applaud @brownpvd.bsky.social colleagues @willoldham.bsky.social & Dr. Klinger who were recognized for their own stellar work!

Post Doctoral Rsrch Assoc at Brown University Health Brown University Health is Hiring! Search available jobs or submit your resume now by visiting this link. Please share with anyone you feel would be a great fit.

📣 We are recruiting a post-doctoral fellow!
Join an interdisciplinary, NIH-funded research program studying metabolic reprogramming in pulmonary fibrosis with strong translational focus and collaborative environment. Apply here: jobs.brownhealth.org/search/jobde...

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

When I ask a patient what medicines they take and they wave their hands and say “it’s in the chart” I need them to understand that “the patient’s chart” is a mythical concept, more akin to the scattered scribblings of the British constitution rather than a single, comprehensive document.

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!

I think gt does this? gt.rstudio.com/reference/gt...

sharpie on white paper: Paragraph 1: we have a big problem P2: considering new thing X reveals pivotal, newly tractable gaps in our knowledge of the big problems P3: So our unifying scientific goal is... Aim N: Active Verb. Method to test interesting (not null) hypothesis in data . . . Impact: This will make the world better and open up new research frontiers via...

Handed out, yet again, the basic #ScrawledGrantAdvice Aims page structure

some light teasing for an upcoming quarto revealjs plugin I have been working on

Picture of the tall, square, brick tower of one of many palazzos in the old walled city of Lucca, Italy.

Looking for the hay bales at the base of the tower…

#IYKYK #grclung2025

Woohoo! Latest preprint from the lab describing how fibroblasts can use alanine to bypass glutamine requirements for differentiation and ECM production. It's a lovely example of metabolic flexibility with implications for how we study cell metabolism. Shout out to Fei Li, who led this work! #cureipf

Still regretting the 4 month period 13 years ago when I went all in on the Mac office suite...

📢 Get ready to submit your abstract to PVRI 2026 Dublin — registrations & the abstract portal will open on 1 July! Stay tuned for full details on how to register and submit your abstract! pvrinstitute.org/pvri2026
#PVRI2026 #PulmonaryHypertension #GlobalScience #Congress

This JUST came up again and @ruben.the100.ci pointed me to the @malte.the100.ci blog explaining how to do it:

Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)

our lightsaber

Excited to announce that, In 26 days, I will be joining Brown University Health! Excited for new colleagues, new opportunities, and renewed energy to advance our work toward a cure for pulmonary fibrosis!

Phew! I was worried for a minute that I let the cat out of the bag, but it is internet official.

pvrinstitute.org/learning-hub...

Such a great meeting! Looking forward to #PVRI2026 in Dublin!

#rstats folks: If you have a habit of updating your library after an R upgrade by copying the old one and run update.packages().

--> DON'T DO THAT <--

Especially not with 4.5.0. You will overwrite base packages with ones from a previous version and as these are not on CRAN, things go bad.

Thanks so much @navneetsinghmd.bsky.social @brownpvd.bsky.social for the opportunity to visit and hospitality! Wonderful to be able to see you all! @gauravchoudhury.bsky.social @willoldham.bsky.social

Thanks! This is superhelpful!

Taking Control of Plot Scaling Learn how to control scaling of the content in your plot when you render plots to different sizes.

This helped me a lot: www.tidyverse.org/blog/2020/08...

#rstats folks! Does anyone have workflow tips on using ggplot2 in both manuscripts and slide presentations? Currently using targets to generate panels/figures themed for manuscript. These are not easy to port to slides given size of points, fonts, etc. Any advice appreciated!

A clear glass chromatography column oriented vertically filled with white matrix striped with a red and a brown band separating along the column.

Breaking in a new column today and, gosh, sometimes it’s nice to be able to SEE the science! #scienceincolor

I do not pay the kind of attention to college basketball that I once did but it is still important to take time out of my day to root against Duke

🏋️‍♀️ Strength training is vital for women entering #menopause - boosting metabolic, mental, & bone health. But like any intervention, it needs proper assessment & guidance. I started at 43, lifting heavy: no injuries. The secret? Good coaching, mobility, movement literacy, slow progression, and rest.

Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy - Nature Communications Senescent cells accumulate in tissues with aging and disease but are difficult to detect due to distinct cell-type-specific senescence phenotypes. Here, the authors present the SenePy algorithm to ide...

Senescent cells contribute to disease and are found in many tissues but are hard to analyze because markers have been derived in culture and do not account for cell-type differences. Here, we define new signatures based on millions of single cells (1/5) www.nature.com/articles/s41...

Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies - Respiratory Research Background Human precision-cut lung slices (hPCLS) are a unique platform for functional, mechanistic, and drug discovery studies in the field of respiratory research. However, tissue availability, gen...

Happy to share our work on cold storage of pcls. Hoping this will be of interest to many and will help to store, share and expand the use of PCLS in #lungresearch. Kudoz to Camila and Fee who Share first authorship. @atscommunity.bsky.social respiratory-research.biomedcentral.com/articles/10....

Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis - Nature Genetics Xenium spatial transcriptomic profiling of pulmonary fibrosis characterizes cell composition dynamics and histopathological features associated with the disease.

Excited to post my first #skySplain about our recent work published yesterday in Nature Genetics! www.nature.com/articles/s41.... One of the first authors of this study - Annika Vannan – actually wrote this breakdown, but she's not yet over here on bluesky and asked me to post!

Say what you will about the antiquity of beepers as a technology, but when that’s the only number anyone can reach you at, then the person holding the beeper is the only person who gets disturbed by the beeping.