Jaime Agudo-Canalejo

Our recent work about topological phase locking in stochastic oscillators with @agudocanalejo.bsky.social and Ramin Golestanian just got published in Nature Communications. @natcomms.nature.com

Here is the link for the article: www.nature.com/articles/s41....

Paper alert! With Ramin Golestanian and @agudocanalejo.bsky.social , and by utilizing tools from non-equilibrium statistical physics and dynamical systems theory, we constructed a new paradigmatic framework which allows us to propose mechanistic rules for de novo design of enzymes.

Mechanistic rules for de novo design of enzymes We develop a minimal model for an enzyme that allows us to extract a set of golden rules regarding its optimal design. We discover that two key ingredients of momentum conservation and a generically present dissipative coupling give rise to a bifurcation in the dynamical phase portrait of the low-dimensional configuration space, which enables enzymatic activity as an emergent feature of the dynamics, via a fundamentally novel mechanism not accessible to Kramers-like energy-barrier-crossing descriptions in terms of reaction coordinates.

Online Now: Mechanistic rules for de novo design of enzymes #catalysis

Synthetic cells get into shape - Nature Physics Shape changes in biological cells are driven by an active network of biopolymers. Now, similar deformations are observed in synthetic cell membranes.

Thanks to @agudocanalejo.bsky.social and @raovutukuri.bsky.social [amongst the first ones to observe large fluctuations in GUVs!] for today's News and Views about our recent paper on active vesicle deformations - and I agree with the conclusion, it's just a beginning..! doi.org/10.1038/s415...

Thanks!

Thank you to the IOP Biological Physics group for this award! It's a pleasure to contribute to the biological physics community in the UK.

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

📣 We are hiring! Postdoc opportunity in Quantitative Immunology at University College London.
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🔬 Develop computational approaches to discover clonal and functional T cell determinants of protection against Tuberculosis. Fully funded 2-year position.

🗓️ Apply by Dec 10 www.ucl.ac.uk/work-at-ucl/...

Come work with me! Two fully-funded PhD positions in Theoretical Physics of Living Matter are available in my group at UCL, in the wonderful city of London . For more information and to apply, visit www.agudo-canalejo.com/work-with-us

Next up #UKMT2024, more endosomes (yay) 🤓

Shubhangi Sharma from Jitu Mayor’s lab with some great insights into how membrane tension drives less conventional endocytic processes and @agudocanalejo.bsky.social showing cool bending and scission of endosomal membranes driven by condensates.

Hi @micromotility.bsky.social great idea! Could you add me please? Thanks!

Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN

I’m proud to join more than 30 colleagues today in sharing our analysis of potential risks from “mirror life”. We summarize our findings in a @science.org article, and in greater detail in a 300pg technical report:

Article: www.science.org/doi/10.1126/...
Report: purl.stanford.edu/cv716pj4036