Jiwon Ryu

People With Severe Diabetes Are Cured in Small Trial of New Drug

💥 🍃 🏥 New Stem Cell Therapy Effective for Severe Diabetes (Type 1)
🧪
Single treatment led to reduced or no need for insulin in all 12 patients

New England Journal of Medicine Report
nejm.org/doi/full/10.1056/NEJMoa2506549
Gift Article NYT

@rrbehringer.bsky.social

the first Dev Bio starter pack:

go.bsky.app/M5AgJhn

#SkeletalMuscle #Mitophagy #ERPhagy

ACTA1-Cre::BNIP3L KO🐭muscle
👉Accumulated Mitochondria
👉⏬glycolytic myofiber ⏬oxidative fiber
👉⏫ #ERPhagy (ER-mCherry/GFP-LC3; ER-Emerald/LysoTracker) ⏬ER Ca2+
👉Centronuclear myopathy

@josephwgordon.bsky.social #Autophagy 2025
www.tandfonline.com/doi/full/10....

Trying to find all the metabolism/mito folks on here, so i created a starter pack. Please suggest anyone I missed!
go.bsky.app/C2t7snh

If the NIH gets messed up, there is no alternative. Not just in the US, but globally. It is by far the biggest engine of health research in the world. Which is why the idea that US scientists can just do their work elsewhere is a little fanciful.
donmoynihan.substack.com/p/politicizi...

Hello everybody, we are excited to be here! 👋

We will share news related to the psychiatric and neuroscientific research we do, as well as news about our Institute as a whole.

Happy to connect with all of you! 🥳

#science #neuroskyence #PsychSciSky

Functionally blind man gets sight back after gene therapy A 31-year-old Sligo man who was functionally blind has got his sight back, after being treated with a new gene therapy at the Mater University Hospital in Dublin.

A 31-year-old Sligo man who was functionally blind has got his sight back, after being treated with a new gene therapy at the Mater University Hospital in Dublin.

I don't see a cancellation note anywhere but I would be surprised if it met.

We'll see...

My continued biological education

Making the connection: How membrane contact sites have changed our view of organelle biology

A fascinating network of Organelles (Birth & Death)

How #ERStress modulate ER-#LipidDroplet to drive Atherosclerosis?😎

#Cell 2024
www.sciencedirect.com/science/arti...

Meet the newly discovered brain cell that allows you to remember objects

"Discovery of ‘ovoid cells’ reshapes our understanding of how memory works, and could open the door to new treatments for Alzheimer’s disease, epilepsy and more"

www.nature.com/articles/s41...

Diffuse Axonal and Vascular Pathology in the Gyrencephalic Brain after High-Energy Blunt Injury: Clinicopathological Correlations Involving the Brainstem | Journal of Neurotrauma Traumatic brain injury (TBI) after high-energy, behind helmet blunt trauma (BHBT) is an important but poorly understood clinical entity often associated with apnea and death in humans. In this study, ...

Our new paper is out! Even with helmet protection, high-energy blunt trauma can lead to fatal respiratory failure. Our study maps specific brainstem injury patterns, revealing critical implications for #TBI & protection. Patterns of #vascularinjury ≠ #axonalinjury www.liebertpub.com/doi/10.1089/...

We've launched a Berman Institute starter pack - we will update as more members of our community join Bluesky: go.bsky.app/BRM6bpj

Automation of Ultrasonographic Optic Nerve Sheath Diameter Measurement: A Scoping Review
onlinelibrary.wiley.com/doi/10.1111/...

#neuroimaging #neurology #neuroskyence #radiology #AI #ultrasound #opticnerve

Here's a first collection of great life science institutes worldwide you can follow to help you get back in the loop. 🌍🔬

Did we miss any? Let us know, and we'll add them!

go.bsky.app/A5Jrf8N

Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection - Nature Medicine Blood biomarkers in a middle-aged population suggest that SARS-CoV-2 infection is associated with greater brain β-amyloid plaque accumulation.

More B-amyloid fibrillation in the brain --> more B-amyloid presence in the plasma. Here it goes, published today at @NatureMedicine. Are we seeing the initial spike of Alzheimer's cases reserved for the near future? Thank you @andrewewing11.bsky.social
#NeuroCovid
www.nature.com/articles/s41...

A genome-wide atlas of cell morphology reveals gene functions PERISCOPE, a technique for genome-wide imaging screens, is helping Broad scientists understand the connections between genes and traits.

A new technique for genome-wide imaging screens called PERISCOPE could help scientists understand the connections between genes and traits.

@drannecarpenter.bsky.social @naturemethods.bsky.social #Science

Challenging the Axon’s Classic Shape Forget the traditional tubular shape—researchers are investigating a pearl-on-a-string formation for axons, unlocking new insights into neural signaling in health and disease.

another piece, covering our work! Thanks to Laura Tran at the Scientist!!
www.the-scientist.com/challenging-...

FDA Approves LEQEMBI® (lecanemab-irmb) IV Maintenance Dosing for the Treatment of Early Alzheimer's Disease /PRNewswire/ -- Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, "Eisai") and Biogen Inc. (Nasdaq: BIIB, Corporate headquarters: Cambridge,...

The FDA is still approving drugs. Via @adamfeuerstein.bsky.social

www.prnewswire.com/news-release...

✨NEW STARTER PACK✨ Check out our growing list of resources, societies, and tools that are useful to the everyday lives of #zebrafish researchers! go.bsky.app/JcC5df3 🧪

rupress.org/jcb/article/...

We've put together a collection of the writers and editors who work on news, features, opinion and research at Nature magazine. Follow them all here:

go.bsky.app/JARysRt 🧪

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍

Preprint📜: www.biorxiv.org/content/10.1...

A short thread🧵👇

Diffuse Axonal and Vascular Pathology in the Gyrencephalic Brain after High-Energy Blunt Injury: Clinicopathological Correlations Involving the Brainstem | Journal of Neurotrauma Traumatic brain injury (TBI) after high-energy, behind helmet blunt trauma (BHBT) is an important but poorly understood clinical entity often associated with apnea and death in humans. In this study, ...

www.liebertpub.com/doi/10.1089/...

Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice - Nature A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional chan...

🔥 Inflammation and neuron protection

In aging brains, genes associated with inflammation became more active, while those related to neuronal structure and function decreased.

Read the publication 📜 nature.com/articles/s41...

"an accurate pan-tissue, pan-histone-mark age predictor"😎

1814 ChIPseq samples
H3K4me3
H3K27ac
H3K9ac
H3K9me3
H3K27me3
H3K36me3
H3K4me1

82 tissues (incld large arteries)

"only a small fraction of the 62,241 features is sufficient to predict age"

#SciAdv 2024
www.science.org/doi/10.1126/...

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology

www.biorxiv.org/content/10.1...

New: @themitotracker.bsky.social et al. from @labfriedman.bsky.social identify a mitochondrial inner membrane protein that marks and facilitates a subset of sites of mitochondrial fission in human cells. rupress.org/jcb/article/...

New year, new discoveries, new price point. SPRQ chemistry for #Revio is now shipping, making 2025 the year a HiFi human genome costs less than $500. Add SPRQ to your wishlist and let discovery ring in the new year. 🧬✨

Resharing a starter pack i made a while back for those interested in Neuroscience and Metabolism research. Some recent additions are included.

Let me know if you want to join!

go.bsky.app/DGJS44y

Neuroskyence: 🧠🟦 or 🧠📈
Interoception: 🧠🫀 or 🧠🫁