Vlad Bondarenko

Appreciate Quanta for shining a light on our joint work with Simon Gsell, Sham Tlili (@shamtlili.bsky.social), and Matthias Merkel (@merkellab.bsky.social).

Induction of menstruation in mice reveals the regulation of menstrual shedding During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Fully-funded 4-year PhD Opportunities available at the @crick.ac.uk , including a project in our lab on human #embryomodels Feel free to share with anyone interested, and apply through the online portal before 5th November! 👏

www.crick.ac.uk/careers-stud...

Congratulations, Jaroslav! 👏🎊 & greetings from FMI

🔴✨ Exciting opportunity : we're hiring a PhD student! ✨🔴

👉 Don't hesitate to apply or spread the word!

⏰ Deadline 30th November 2025

ℹ️ More information and application : www.crg.eu/en/content/t...

@crg.eu @prbb.org

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

THANK YOU for many years of friendship, support and for sharing your great Science
La Pedrera #Barcelona
#NotInTheGenes #CellsRUs #Cambridge

Wow, what great news 👏 !!!
Huge congrats, @nveits.bsky.social 🥳🥳✨️ looking forward to reading it!

How is developmental speed regulated ? 🪰

Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.

www.biorxiv.org/content/10.1...

A big thanks to everyone involved!

We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics.

We applied this workflow to map precancerous lesions of the fallopian tubes.

More here: www.biorxiv.org/content/10.1...

Core achievement unlocked!! Congrats to Fabrizio amd all authors!!

Trump Says the U.S. Will Institute $100,000 Fee for Skilled Worker Visas

I was on a H1B visa for part of my postdoc. Also when I started as Assistant Professor. Several of my postdocs where on H1Bs. This new fee will affect more academia than tech or finance companies because there is no way universities can pay that…

www.nytimes.com/2025/09/19/u...

Peer pressure shapes the gut International research team develops mechanical model to explain the shaping of the fruit fly hindgut by forces from neighbouring tissues

Peer pressure shapes the gut: latest publication in @pnas.org by @lepuslapis.bsky.social, @zhaoshh.bsky.social from @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social with colleagues from @flatironinstitute.org and Princeton University. www.mpi-cbg.de/news-outreac...

HDAC3 prevents enhancer hyperactivation to enable developmental transitions Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

Regulation of epithelial tissue homeostasis by active trans-epithelial transport Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...

Federal budget cuts: impact on the SNSF The SNSF rejects the cuts but is preparing for them. Together with its partners, it has decided to cut costs across several funding schemes.

📢 The Federal Council plans to reduce the SNSF's budget by 270 million Swiss francs. The SNSF rejects these cuts. However, in order to be prepared, it has decided to cut costs in consultation with all partners.

➡️https://sohub.io/n2b1

#research #science #CHParl

Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development - Nature Communications The placenta plays vital roles in supporting fetal development. Here, Richards et al. develop a high-throughput bioprinted trophoblast organoid model to recapitulate the microenvironment of the e...

I made the world’s first bioprinted placenta organoids (mini placentas) and they’ve just been published in @natureportfolio.nature.com

We found that the matrix environment chosen for these organoids was critical to how they grew and developed 🤰

idp.nature.com/authorize?re...

I am excited to announce that we are looking for a Lab Manager @fmiscience.bsky.social in Basel. If you want to be part of a growing team investigating development and tissue formation, and are enthusiastic about helping set up a new lab, please check out the role:

www.fmi.ch/education-ca...

Order matters! Aurelien Roux @rouxlab.bsky.social studied the formation of multi-cellular tornado-like structures and regeneration of heads in hydra to share with us how stress fields, topology and geometry of initial tissue organization set the sequence of morphogenesis. #MBIMPG2025

Amazing news! Huge congratulations, Ina & the team💫 👌

Join EMBL as a research group leader in AI in biology. EMBL AI is our new initiative aiming to exploit the full potential of ML/AI-based approaches to advance our understanding of the most complex system in the known universe - life on Earth.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
(1/3)

Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.

doi.org/10.1101/2025...

Epithelial tension controls intestinal cell extrusion Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

📣 It is my pleasure to announce our recent review with Margherita on the current approaches, challenges, and perspectives in studying human maternal-fetal interface using in vitro models www.cell.com/cell-stem-ce... 🚀✨️

Huge congrats, David & the group!! 👏

I am excited to share that I will join the Friedrich Miescher Institute @fmiscience.bsky.social in Basel as a group leader, starting my lab in March 2026 🎉

We will explore cell fate regulation during organogenesis, with a focus on how cell elimination underlies the emergence of functional tissues.

🚨 Job Alert: we seek a Lab Manager for @juliabatki.bsky.social's new group (start Mar 2026), which will study cell fate regulation during organ development. Join the Batki's group to drive experiments & lab operations! Apply at: www.fmi.ch/education-ca...

We are searching for an enthusiastic scientist to join our team and establish annual killifish as a model system for early developmental biology and biophysics! @embl.org @embldbunit.bsky.social

Apply here:
embl.wd103.myworkdayjobs.com/EMBL/job/Hei...

Please re-post 🙏

We’re expecting many talented contributors! Don’t miss the chance to be part of the discussion on Causality in Biology and AI, and join us at the Symposium on 10-11 November 2025 at the PRBB Auditorium! Register using the link below.

You have until 15 Sep to submit abstracts. #CallForAbstracts

Cellular memory: The clever strategy cells use to move through narrow environments In wound healing, immune response, and cancer metastasis, cells migrate through the body – often squeezing through narrow spaces. Researchers led by Prof. David Brückner at the Biozentrum discovered t...

🧪How do cells navigate the body? David Brückner @davidbrueckner.bsky.social & researchers @umons.bsky.social discovered that cells retain a “memory” of their past shapes, allowing them migrate more efficiently–crucial for immune response & metastasis. @unibas.ch @natphys.nature.com ow.ly/SSzX50WLg3t