Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

Nature research paper: Lymph node environment drives FSP1 targetability in metastasizing melanoma

go.nature.com/49yHIAk

Targeting FSP1 triggers ferroptosis in lung cancer - Nature The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggesting its potential as a therapeutic target in lung cancer.

Nature research paper: Targeting FSP1 triggers ferroptosis in lung cancer

go.nature.com/495x0kM

The making and remaking of Marie Curie The famous physicist's legacy looms large 150 years after her birth

Happy 158th Birthday, Marie Skłodowska Curie! She was the first woman to receive a Nobel Prize and the first person to receive the honor twice.

In 2017, #ScienceBooks toured the dynamics that established her as "the most iconic of all female scientists." https://scim.ag/47tkKYA

From MRI to Ozempic: breakthroughs that show why fundamental research must be protected In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

In praise of fundamental research
Our editorial this week argues that I n these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different
🧪
@nature.com
www.nature.com/articles/d41...

Black and white portrait of John Gurdon, 1971

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews

A photo of a Nobel medal

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

From gene lists to context drift Treatment resistance limits long-term effectiveness in cancer therapy. Conventional biomarkers typically rely on static gene expression levels. In this issue of Cancer Cell, Jassim et al. report a new approach, RECODR, which captures how gene relationships shift over time, uncovering hidden drivers of resistance and suggesting effective combination treatments.

Online Now: From gene lists to context drift

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature 17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Nature research paper: Multiple oestradiol functions inhibit ferroptosis and acute kidney injury

go.nature.com/45Ky3Et

Adipose tissue as a linchpin of organismal ageing - Nature Metabolism Nguyen and Corvera review distinct changes that occur in adipose tissue during ageing, discuss potential mechanisms by which these changes impact whole-body metabolism, immunity and longevity, and highlight therapeutic opportunities.

#Throwback 🧪

REVIEW | Adipose tissue as a linchpin of organismal ageing

T Nguyen & S Corvera

Monoclonal antibodies revolutionized biomedical science and health care The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.

The story of the discovery of monoclonal antibodies 50 years ago shows how the free exchange of ideas can lead to life-changing treatments

go.nature.com/45GeSM0

Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...

💫The July issue of @natgenet.nature.com is out!

Featuring:

✅retrotransposons in limb malformation and cancer
✅single-cell Micro-C
✅long-term effects of chemotherapy on normal blood cells
✅blood regulatory variation map in South Africans

And more!

⬇️

www.nature.com/ng/volumes/5...

So it’s not just chromosomes—God checks the iron levels too🤭

How a mysterious epidemic of kidney disease is killing thousands of young men Nature - Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail.

Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail

https://go.nature.com/3Ze2sri

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early events during cancer development.

Nature research paper: Multigenerational cell tracking of DNA replication and heritable DNA damage

https://go.nature.com/4jxWDMJ

Join for the first FASEB Ferroptosis conference in the US this July! This stellar speaker line up brings together almost all leaders in the field!

Four rising stars at the forefront of cancer research These scientists are coming at cancer from all angles.

We've just published our new Cancer supplement for @nature.com, which features four impressive young researchers - @oriolpich.bsky.social @frogsandstars.bsky.social

go.nature.com/4iwN7c8

Recommendations for robust and reproducible research on ferroptosis Nature Reviews Molecular Cell Biology, Published online: 09 April 2025; doi:10.1038/s41580-025-00843-2Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in disease. This Expert Recommendation article summarizes ferroptosis regulation and mechanisms and provides recommendations to increase the reproducibility and robustness of ferroptosis research.

New Online! Recommendations for robust and reproducible research on ferroptosis

Congrats Anna🍻

Encorafenib, cetuximab and chemotherapy in BRAF-mutant colorectal cancer: a randomized phase 3 trial - Nature Medicine As presented at the 2025 ASCO GI Cancers Symposium: in the phase 3 BREAKWATER trial, patients with previously untreated BRAF V600E metastatic colorectal cancer received the BRAF inhibitor encorafenib,...

📰 hot off the press in #NatureMedicine & presented today at #GI25: The phase 3 #BREAKWATER trial in patients w/ BRAFV600E metastatic #ColorectalCancer
🗝️ finding: Encorafenib + cetuximab + mFOLFOX6 ⬆️ ORR vs standard of care
www.nature.com/articles/s41...
#OncSky #CRCSM @natureportfolio.bsky.social

Aspartate signalling drives lung metastasis via alternative translation - Nature Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.

new out in Nature www.nature.com/articles/s41...