Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...

💫The July issue of @natgenet.nature.com is out!

Featuring:

✅retrotransposons in limb malformation and cancer
✅single-cell Micro-C
✅long-term effects of chemotherapy on normal blood cells
✅blood regulatory variation map in South Africans

And more!

⬇️

www.nature.com/ng/volumes/5...

So it’s not just chromosomes—God checks the iron levels too🤭

How a mysterious epidemic of kidney disease is killing thousands of young men Nature - Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail.

Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail

https://go.nature.com/3Ze2sri

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early events during cancer development.

Nature research paper: Multigenerational cell tracking of DNA replication and heritable DNA damage

https://go.nature.com/4jxWDMJ

Join for the first FASEB Ferroptosis conference in the US this July! This stellar speaker line up brings together almost all leaders in the field!

Four rising stars at the forefront of cancer research These scientists are coming at cancer from all angles.

We've just published our new Cancer supplement for @nature.com, which features four impressive young researchers - @oriolpich.bsky.social @frogsandstars.bsky.social

go.nature.com/4iwN7c8

Recommendations for robust and reproducible research on ferroptosis Nature Reviews Molecular Cell Biology, Published online: 09 April 2025; doi:10.1038/s41580-025-00843-2Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in disease. This Expert Recommendation article summarizes ferroptosis regulation and mechanisms and provides recommendations to increase the reproducibility and robustness of ferroptosis research.

New Online! Recommendations for robust and reproducible research on ferroptosis

Congrats Anna🍻

Encorafenib, cetuximab and chemotherapy in BRAF-mutant colorectal cancer: a randomized phase 3 trial - Nature Medicine As presented at the 2025 ASCO GI Cancers Symposium: in the phase 3 BREAKWATER trial, patients with previously untreated BRAF V600E metastatic colorectal cancer received the BRAF inhibitor encorafenib,...

📰 hot off the press in #NatureMedicine & presented today at #GI25: The phase 3 #BREAKWATER trial in patients w/ BRAFV600E metastatic #ColorectalCancer
🗝️ finding: Encorafenib + cetuximab + mFOLFOX6 ⬆️ ORR vs standard of care
www.nature.com/articles/s41...
#OncSky #CRCSM @natureportfolio.bsky.social

Aspartate signalling drives lung metastasis via alternative translation - Nature Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.

new out in Nature www.nature.com/articles/s41...