ISB

Personalized Clostridioides difficile colonization risk prediction and probiotic therapy assessment in the human gut Carr et al. show how microbial community-scale metabolic models (MCMMs) predict personalized Clostridioides difficile colonization risk and probiotic efficacy. MCMMs reveal key metabolic strategies ex...

💥Personalized C. difficile colonization risk prediction and probiotic therapy assessment in the human gut💥

I'm very excited about this work, driven by Alex Carr & co-supervised by @cdiener.com

@cp-cellsystems.bsky.social @isbscience.org @nitinbaliga.bsky.social

www.cell.com/cell-systems...

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🦠 New paper out today in @cellpress.bsky.social's Cell Systems! ISB researchers show how personalized gut models can predict – and help prevent – dangerous C. diff infections before they strike.
Cell Systems paper: www.cell.com/cell-systems...
ISB news story: isbscience.org/news/health/...

A Simpler, Smarter Way to Measure Gut Bacterial Biomass ISB has developed a fast, affordable gut bacterial biomass measurement from stool data, advancing microbiome research and health insights.

For a pop-sci digest of this work, check out the @isbscience.org news story here: isbscience.org/news/health/...

Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization | mSystems In this study, we asked whether normalization by host reads alone was sufficient to estimate absolute bacterial biomass directly from stool metagenomic data, without the need for synthetic spike-ins, ...

You can get an accurate estimate of total bacterial biomass from stool metagenomes by simply normalizing by host read count, without needing any additional measurements.

Excellent work by UW Master's student Gechlang Tang in @asm.org #mSystems Journal.

journals.asm.org/doi/10.1128/...
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RECOVER 2.0: New Insights and Next Steps in Long COVID Research Catch up on ISB’s RECOVER Town Hall for Long COVID research, RECOVER 2.0, clinical trials, plus insights from study participants.

What’s next for #LongCovid research? RECOVER 2.0 aims to define long-term disease trajectories & test new treatments. Watch @isbscience.org's recent town hall conversation with researchers & coordinators from Providence Swedish, @uwmedicine.bsky.social & Cedars-Sinai. isbscience.org/news/isb-eve...

New Tool Unlocks Biomedical Discovery with Launch of Biomedical Data Translator Biomedical Data Translator intuitively integrates biomedical datasets, empowering researchers to generate data-driven insights.

Announcing the initial public release of the Biomedical Data Translator, a powerful open-source knowledge graph-based system designed to integrate and harmonize vast, complex biomedical datasets to accelerate translational science and patient care.
isbscience.org/news/health/...

Announcing the Biomedical Data Translator: Initial Public Release - PubMed The growing availability of biomedical data offers vast potential to improve human health, but the complexity and lack of integration of these datasets often limit their utility. To address this, the ...

"Announcing the Biomedical Data Translator: Initial Public Release" pubmed.ncbi.nlm.nih.gov/40635371/

Translator is the knowledge-graph integration system we're developing to support hypothesis generation by scientists. Funded by NCATS.
As I said in the past, best consortium ever. Awesome people.
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RECOVER Event banner

Join us on Monday, July 28 from 5 - 6 p.m. for a virtual event on Long COVID research, hosted by the PNW Consortium of the RECOVER study.

Following talks, audience members will have the opportunity to ask questions directly to the panel during a live Q&A. Register: us02web.zoom.us/webinar/regi...

What Your Gut Knows About Your Diet Dr. Sean Gibbons discusses a breakthrough method that analyzes food-derived DNA in fecal metagenomes and what this means for human health

Be sure to listen to @gibbological.bsky.social's recent interview on the Finding Genius podcast! www.findinggeniuspodcast.com/podcasts/wha...

Researchers from @isbscience.org are using generative AI to unlock new understanding of human immunity. These discoveries could help predict disease severity and improve #CancerTherapies.

🤔 Learn about TARPON, created by Dr. Jim Heath and Daniel Chen: bit.ly/4kjTAb5

We are thrilled to welcome three incredible new members to ISB's Board of Directors! Welcome Kevin Fitzwilson, Bill Wright, PhD, and Rod Hochman, MD!

Read their bios and see all of our board members here: isbscience.org/people/?grou....

The Human Body as a Microbial Ecosystem—Sean Gibbons Sean Gibbons, PhD, is a distinguished investigator at the Washington Research Foundation and assistant professor at the Institute for Systems Biology.

ISB Associate Professor Dr. Sean Gibbons (@gibbological.bsky.social) was a guest on the Finding Genius podcast. The episode is titled “The Human Body as a Microbial Ecosystem” – you can listen the episode here: www.findinggeniuspodcast.com/podcasts/the...

How Generative AI Is Helping Decode the Human Immune System Discover how ISB is using generative AI to unlock immune system insights across aging, cancer, and disease in this Research Roundtable.

Generative AI meets human immunity: @isbscience.org’s Jim Heath shows how a new model, TARPON, reveals immune rule-breaking that could explain disease severity, aging, and more.
Watch the talk + read the recap: isbscience.org/news/isb-eve...

Metabolic modeling reveals determinants of synbiotic efficacy in a human intervention trial. Synbiotic interventions show variable effects across individuals, likely driven by ecological interactions with the endogenous microbiota and the host diet. Rationally predicting individual-specific s...

Our latest preprint is online @medrxivpreprint.bsky.social:

"‪Metabolic modeling reveals determinants of synbiotic efficacy in a human intervention trial." www.medrxiv.org/content/10.1...

Amazing work here by postdoc Nick Quinn-Bohmann @isbscience.org

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🦠 Microbial communities perform some of the planet’s most important work.

Drs. Alex Carr and Nitin Baliga at @isbscience.org has shown that critical microbial partnerships are vulnerable to disruption in contaminated environments: bit.ly/4k6WbFm

Microbes That Keep Ecosystems in Balance Can Fall Apart Easily, New Study Finds Microbial teamwork behind denitrification can collapse in polluted environments, threatening ecosystem balance and resilience.

New @isbscience.org research shows how microbial teamwork behind denitrification can collapse in polluted environments, threatening ecosystem balance and resilience. isbscience.org/news/environ...

How can generative #AI transform our understanding of the immune system? Join Dr. Jim Heath for a compelling Research Roundtable discussion designed for a general audience. Includes live Q&A.

Register here: give.isbscience.org/research-rou...

Medical digital twins: enabling precision medicine and medical artificial intelligence The notion of medical digital twins is gaining popularity both within the scientific community and among the general public; however, much of the rece…

A new article in The Lancet Digital Health co-authored by @isbscience.org's Lee Hood, the late Ilya Shmulevich and colleagues outlines a 5-part framework for medical digital twins – virtual models of individuals that could advance personalized medicine.
Read: www.sciencedirect.com/science/arti...

⏳ RECOVER Town Hall Event: Monday, 6/23, 6-7 p.m. PT
🎟 REGISTER FOR FREE: us02web.zoom.us/meeting/regi...

We're ONE WEEK AWAY from the virtual RECOVER Town Hall event. You'll hear updates from the PNW Consortium team, followed by a live Q&A. Send questions upon registering. #longCOVID

Gut Microbiome Expert: The HIDDEN Side Of Health You're MISSING | Dr. Sean Gibbons — Optispan

Matt Kaeberlein welcomed @isbscience.org's @gibbological.bsky.social on the Optispan #podcast. The long-form conversation touched on a number of fascinating topics. Watch/listen below, or on Youtube, Apple Podcasts, Spotify, or wherever you get your podcasts.

www.optispan.life/podcast/v/2f...

Many thanks to the incredible team: Clifford Rostomily, Ameek Bhalla, Gary Wormser, Lance Pflieger, Mary Brunkow, Noa Rappaport, Leroy Hood, and the entire @isbscience.org Lyme team.
Deeply grateful to our funders: DOD USAMRAA, Wilke Family Fdn, Steven & Alexandra Cohen Fdn, Global Lyme Alliance.

RECOVER Town Hall – June 23, 6-7pm PT (Virtual)
Updates from the PNW RECOVER team + live Q&A with Dr. Jim Heath, Dr. Jason Goldman & research coordinators.
Register: us02web.zoom.us/meeting/regi...
#LongCOVID #RECOVER @uwmedicine.bsky.social

Mark your calendar: June 24, noon PT 🧠💻
@isbscience.org President and Professor Dr. Jim Heath unpacks how Generative #AI is changing what we know about the immune system — and why it matters for your health.
Free, virtual, open to all.

🔗 Register today! give.isbscience.org/research-rou...

Business or pleasure, the Gibbons Lab is laser focused! 😀

On brand!

YouTube video by Progress, Potential, and Possibilities Dr. Sui Huang, MD, PhD - ISB - Complex Systems Approaches For Biomedical Research

Our own Dr. Sui Huang had a great week! Catch his interview on the Progress, Potential, and Possibilities #podcast with Ira S. Pastor, recorded just before his recent Research Roundtable on #cancer. Watch it here: www.youtube.com/watch?v=LoUk...

Beyond Faulty Genes: Sui Huang Presents a Cancer Paradigm Shift Research Roundtable: Sui Huang proposes a cancer paradigm shift, challenging the genetic view for one based on cell state transitions.

Interesting discussion at @isbscience.org's Research Roundtable with Dr. Sui Huang on moving beyond the genetic paradigm of cancer. Explores cell state transitions and new treatment ideas. Watch the video: isbscience.org/news/isb-eve...

From 'Genesis' to Reality: Decoding the AI Revolution Learn about the future of AI and its applications in science and biomedicine from a discussion between Craig Mundie and ISB's Jim Heath.

Great conversation on the #AI Revolution last week featuring Craig Mundie and @isbscience.org President Jim Heath! Recap and video available: isbscience.org/news/isb-eve... @townhallseattle.bsky.social

Is cancer solely genetic? 🤔 Join @isbscience.org's Dr. Sui Huang TOMORROW (5/14, noon PT) for a FREE virtual event challenging the dominant view. Register here, and please share widely! give.isbscience.org/research-rou...

Many thanks to the 25 donors who helped us reach the finish line and unlocked the $2,500 challenge match for #GiveBIG! You have made an important impact on our groundbreaking #research and vital #STEM programs – THANK YOU!