@Bruskolab

@biorxivpreprint.bsky.social High-affinity CD155 expression enhances immune evasion of Stem cell-derived β-cells, improving their potential for restorative therapy in type 1 diabetes @bruskolab.bsky.social ‪@mebrown4.bsky.social‬
www.biorxiv.org/content/10.1...

Prevention of diabetic ketoacidosis in relatives screened for islet autoantibodies and followed up in the TrialNet Pathway to Prevention study at a single institution in Italy - Diabetologia Aims/hypothesis Screening for islet autoantibodies is an effective method for identifying individuals with pre-symptomatic (stage 1 and 2) type 1 diabetes. This approach offers a valuable opportunity ...

Early identification of pre-clinical type 1 #diabetes combining autoantibody screening and metabolic monitoring at a single centre fully prevented #DKA at disease onset in relatives of affected patients. #T1D #DiabetesResearch link.springer.com/article/10.1... 🔓

Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development Effector CD8+ T cells are key cellular drivers of type 1 diabetes (T1D) pathogenesis, yet questions remain regarding the molecular defects leading to altered cytotoxicity, their signature in periphera...

Our latest preprint on cellular and molecular phenotypes in T1D is out now. www.biorxiv.org/content/10.1...

Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes This study explores the inflammatory response observed in pancreata and pancreatic lymph node (pLN) samples obtained throughout the natural history of type 1 diabetes (T1D) including non-diabetic indi...

🚨New work from our lab with important clinical implications. Thanks to our collaborators in @TheHPAP. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes | bioRxiv

www.biorxiv.org/content/10.1...

Happening today!

The end of the genetic paradigm of cancer Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...

This paper from cancer should be read by all as a challenge to conventional dogmas. journals.plos.org/plosbiology/...

Science, folks. Science. This is wonderful news.

🎉FOCIS is celebrating 25 years of innovation and impact! 🎉

This June, we’re marking a milestone in our journey of embracing diverse perspectives and fostering global collaboration. 🌍✨

Learn more about what’s coming 👉 zurl.co/iFu1c

#FOCIS2025 #Celebrating25Years

If I did not worry about future prospects for my trainees, I don’t think I would ever publish beyond pre-prints unless there were free open-access society journals.

Extremely pleased to share our new work in collaboration with the @bruskolab.bsky.social lab, where we leveraged one of the largest TCRbeta sequencing datasets to identify T1D-associated TCR-based signatures. Paper link and 🧵 are below. Incredible work led by @puneet021192.bsky.social.

Therapeutic targeting of the T1D-associated costimulatory molecule CD226.
rdcu.be/d2A3k

I clearly feel more comfortable on the water than in the Arizona desert but it was a fun Thanksgiving in both places.

I was honored to talk to @evartesfaye.bsky.social about one community’s effort to stay put in the face of climate change.

“The oyster reef is a living thing. … When the sea level rises, because oysters are growing on it, it will grow vertically as well, so it will continue to add protection.” — me

Please join us for this amazing event. Looking forward to seeing these talks. @ufdiabetes @breakthrought1d.bsky.social

Cedar Key

Looking forward to seeing more science, less garbage.