Check out this important advance in mitochondrial 🧬 lineage tracing by @gaoteng.bsky.social and @wengchen.bsky.social from our group, in collaboration with @jswlab.bsky.social 👇👇
15.02.2026 17:15 — 👍 16 🔁 3 💬 0 📌 0
We turned to population genetics for a solution. The resulting approach, MitoDrift, integrates Wright-Fisher drift dynamics with phylogeny inference via a hidden Markov tree model, enabling us to produce confidence-calibrated lineage trees.
15.02.2026 15:45 — 👍 2 🔁 0 💬 1 📌 0
Mitochondrial lineage tracing brought exciting new capabilities to single-cell genomics. However, a core problem remains: unlike classical lineage recorders, mtDNA mutations can drift and disappear as cells divide, preventing us from precisely decoding lineage history.
15.02.2026 15:45 — 👍 3 🔁 1 💬 1 📌 0
We turned to population genetics for a solution. The resulting approach, MitoDrift, integrates Wright-Fisher drift dynamics with phylogeny inference via a hidden Markov tree model, enabling us to produce confidence-calibrated lineage trees.
15.02.2026 14:36 — 👍 0 🔁 0 💬 1 📌 0
@biorxivpreprint.bsky.social Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans
www.biorxiv.org/content/10.6... @bloodgenes.bsky.social @jswlab.bsky.social @bostonchildrens.bsky.social @hhmi-science.bsky.social @broadinstitute.org
13.02.2026 17:52 — 👍 17 🔁 5 💬 0 📌 0
