Trevor Graham

This looks very cool... implementing mathematical models of cell and tissue biology from plain-text human readable statements. I want to have a play with it! Congratulations Paul @mathcancer.bsky.social and team

Congrats Kit! @yosoykit.bsky.social Extremely worthy recipient of the Leah Edelstein-Kehset prize #SMB2025: she is leading the way modelling disease progression to improve early detection and prevention of #cancer

smb.org/SMB-Awards

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disru...

Goldschmidt's hopeful monsters in cancer: single cell DNAseq shows whole genome doubling (WGD) is an ongoing and frequent mutational process in ovarian cancer. www.nature.com/articles/s41... beautiful work from @sohrabshah.bsky.social and team

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

Schmidt Fellows: if you're a #compbio #AI postdoc, feel free to drop me a line to discuss ideas and I can help you find host labs in the @icr.ac.uk

Postdocs in the USA who'd like to return to Europe to set up their own thing... these could be for you?

www.imperial.ac.uk/jobs/search-...

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

Mathematical modelling of cancer cell evolution and plasticity In this review, we argue that mathematical modelling is an essential tool for understanding cancer cell evolution and phenotypic plasticity. We show t…

New review from @chloecolson.bsky.social on cancer evolution & plasticity from a mathematical modelling lens: www.sciencedirect.com/science/arti...

Chloe provides a framework to think about plasticity & evolution, & explains how maths models can reveal cell dynamics that we can't directly observe.

Advancing cancer research via comparative oncology - Nature Reviews Cancer Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms un...

Enjoyed this @natrevcancer.nature.com article on comparative oncology - how we can learn from other species 🐘🐋🦜🐍 about ways to prevent (& possibly treat) cancer. Both a review and a call to action for the research community. www.nature.com/articles/s41... @atjcagan.bsky.social @cmaley.bsky.social

Congratulations @vinaya-gunasri.bsky.social. Fantastic achievement, look forward to seeing your lab grow.

Closing keynote from the fabulous @atjcagan.bsky.social on "The impossibility of whales" discussing somatic mutagenesis across species. Brilliantly delivered and exceptionally illustrated talk, as anyone who knows Alex's work would expect! #EBECancer25
@eventswcs.bsky.social

Great press write up of @beckilee.bsky.social's DyNAMIC clinical trial, testing adaptive targeted therapy for melanoma with ctDNA guided decision making. The hope is that ctDNA guided treatment cessation and restart (potentially less drug, less often) will improve outcomes for patients.

Who were the ancient Egyptians?

It is expressed in the extraordinary historical and archaeological record, but what about ancestry links to other ancient individuals?

Today we report the successful sequencing of the whole genome of an individual who lived in Egypt about ~4700 years ago.

Now medical oncologist and clinician scientist @beckilee.bsky.social leading the first clinical session. Discussing how to bring evolutionary and ecological ideas into molecular tumour boards, and how to design evo clinical trials for better treatment regimens. #EBEcancer25 @eventswcs.bsky.social

This morning we switch focus to cancer ecology, starting with Marta Luksza @mskcancercenter.bsky.social lecturing on tumour-immune coevolution and immunogenomics. #EBECancer25

@amyboddy.bsky.social @afrankell.bsky.social @yosoykit.bsky.social @sangerinstitute.bsky.social @icr.ac.uk

Our Evolutionary Biology and Ecology of Cancer Summer School #EBECancer2025 in full swing @eventswcs.bsky.social in sunny Hinxton, Cambridge. @florentmouliere.bsky.social giving a deep dive into tracking cancer evolution with cfDNA. @amyboddy.bsky.social @yosoykit.bsky.social @afrankell.bsky.social

Thanks very much Alejo!

Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding - Nature Communications Understanding the dynamics of how drug resistance originates in cancer remains crucial, but it is not possible to observe them directly. Here, the authors construct a mathematical framework to infer d...

Using barcodes 📊 to track cancer 💊 resistance evolution: is it clonal selection or plasticity? @fwhiting.bsky.social‬ knows! His new "Evolutionary Informed Resistance Assays" (EIRAs) framework infers resistance evolution dynamics from barcode diversity data. www.nature.com/articles/s41... @icr.ac.uk

Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling - Nature Communications The authors show that aberrant epithelial GREM1 expression remodels intestinal stroma to form ectopic stem cell niches in mice. Anti-GREM1 reversed these changes, highlighting a potential strategy for...

Lovely new paper from @leedham-simon.bsky.social dissecting epithelium-microenvironment crosstalk through BMP & wnt signalling in the intestine. Inhibition of BMP antagonist GREM1 may forestall polyp formation in Hereditary Mixed Polyposis Syndrome (HMPS). www.nature.com/articles/s41...

Higher or Senior Scientific Officer in Sutton | The Institute of Cancer Research View details and apply for this Higher or Senior Scientific Officer vacancy in Sutton. Salary : Salary from 39,805 to 49,023 Reporting to: Prof Trevor Graham Duration of ...

Single cell whizz with green fingers for molecular genomics? Want to develop and apply new technologies for profiling #cancer #evolution? Like single cell WGS + ATAC: www.biorxiv.org/content/10.1...

Perhaps our senior scientific officer role is for you?

jobs.icr.ac.uk/vacancies/12...

@icr.ac.uk

Data Scientist in Sutton | The Institute of Cancer Research View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £49,023 (depending on the experience) Reporting to: Professor Trevor Graham ...

Calling data scientists: we have opening in our Data Science core @icr.ac.uk to lead work around cancer spatial biology and single cell analysis. These are staff scientist type positions, ideal for someone who wants to help drive computational research. Apply here: jobs.icr.ac.uk/vacancies/12...

Lemongrass sprouting update... now we have two plants and I confirm their leaves are delicious in a curry!

Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma - Nature Cancer Graham and colleagues analyzed locally advanced esophageal adenocarcinoma clinical trial patient samples and identified major changes in gene expression profiles and immune microenvironment compositio...

Tour de force from @melissabarroux.bsky.social on evolutionary and microenvironmental dynamics of oesophageal adenocarcinoma through neoadjuvant therapy

Published @natcancer.nature.com

Melissa is an outstanding new clinician scientist.. one to watch.

www.nature.com/articles/s43...

@icr.ac.uk

Massive experimental quantification allows interpretable deep learning of protein aggregation xAI trained on >100,000 random peptides predicts and elucidates primary sequence determinants of aggregation.

We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With @bennibolo.bsky.social www.science.org/doi/10.1126/...

Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial - Nature Medicine In a phase 2 trial, monitoring tumor resistance mutations in blood using liquid biopsies allowed rationally guided subsequent therapy with anti-EGFR antibodies in patients with colorectal cancer.

yes its very interesting. The same happens with RAS post EGFR blockade in colorectal cancer too, meaning that EGFRi rechallenge may be beneficial: www.nature.com/articles/s41...

Of course, the original idea of Adaptive Therapy was from the visionary Robert (Bob) Gatenby at @moffittnews.bsky.social. His seminal paper:
aacrjournals.org/cancerres/ar...

& lots of work since, with the epicentre being @sandyanderson.bsky.social's Centre at @moffittnews.bsky.social

In other words - remarkably - it could be that less drug, less often leads to better outcomes for some patients with ovarian cancer.

We eagerly await the clinical trial results - they will be definitive.

This means "adaptive therapy" where chemo dose is reduced when the tumour responds well could be a route to long-term tumour control for ovarian cancer (for certain disease types and stages). @mlockley.bsky.social is testing this in the ACTOv clinical trial: bmjopen.bmj.com/content/14/1...

With the brilliant @mlockley.bsky.social we've been exploring chemo resistance evolution in ovarian cancer. We find resistance has a fitness cost which means resistant cells are outcompeted by sensitive cells when treatment is stopped.
aacrjournals.org/cancerres/ar...

@icr.ac.uk @qmbci.bsky.social

Single cell multi-omic whole genome sequencing and chromatin accessibility profiling reveals genome-epigenome coevolution in colorectal cancer Epigenetic alterations co-evolve with genetic mutations to drive carcinogenesis and treatment response. Resolving genome-epigenome coevolution requires accurate multi-omic single cell measurement. Her...

dATAC: our new method for simultaneous very high quality whole genome sequencing and chromatin accessibility profiling of single cells. We used dATAC to trace epigenome clonal evolution in colon cancer. Devised by the extraordinarily talented @maxmossner.bsky.social

www.biorxiv.org/content/10.1...

Higher or Senior Scientific Officer in Sutton | The Institute of Cancer Research View details and apply for this Higher or Senior Scientific Officer vacancy in Sutton. Salary : Salary from 39,805 to 49,023 Reporting to: Prof Trevor Graham Duration of ...

🧬🔬🧫 We have an opening for a senior scientific officer to lead our single cell genomics #techdev and #cancer molecular profiling work @cec-icr.bsky.social

Details and application here: jobs.icr.ac.uk/vacancies/12...

Interested? Please do drop me a line to discuss.

@icr.ac.uk