Trevor Graham

We focused the first #CANPOP on our local SE England community, but would be delighted to open it up nationally or even internationally for #CANPOP2.

Our goal is to help grow the cancer popgen community. Please do shout if you'd like to join us (also we're open to ideas of how to organise this too)

Speakers were:
@carolinewatson.bsky.social (pre-leukaemia)
Verena Körber (Oxford) - SFS modelling
@calumgabbutt.bsky.social - methylation lineage tracing
@benjaminwerner.bsky.social - ecDNA evolution
@zaccasimo.bsky.social - CNA phylogenetics
Liz Murchison (Cambridge) - transmissible cancer

We held the first #CANPOP symposium today (cancer population genetics club) @icr.ac.uk. 6 excellent & didactic talks, all applying mathematical #popgen theory to dissect somatic evolutionary dynamics: spanning the full range of pre-cancer, metastasis through to 6000 year old transmissible cancer...

ProMPt: A modular preclinical platform for functional modelling of prostate cancer heterogeneity and therapeutic vulnerabilities Prostate cancer progression is driven by heterogenous genetic, phenotypic, and microenvironmental programs that remain challenging to model experimentally. Existing systems such as genetically enginee...

First paper from the exceptional Marco Bezzi, group leader in our @cec-icr.bsky.social: a disease-matched syngeneic mouse modelling platform for prostate cancer evolution. Many results here, highlighted is MYC/MAPK driving castration resistance & remodelling tumour microenvrn Congrats! @icr.ac.uk

MI/25/63 Associate Scientist | Cancer Research UK Manchester Institute We are seeking a highly motivated and accomplished Associate Scientist to help lead and shape the programme. You will act as an operational deputy to Professor Samra Turajlic, helping to bridge activi...

Fantastic opportunity from @turajliclab.bsky.social! 🚀

The CanDy Lab is recruiting an Associate Scientist to drive cutting-edge cancer research across @cruk-mi.bsky.social and @crick.ac.uk.

A rare chance to lead, grow, and shape high-impact science 👇
www.cruk.manchester.ac.uk/career/mi-25...

@kevinmonahan.bsky.social & I have an open clinical #PhD position between @stmarkshospital.bsky.social and @icr.ac.uk If you're interested in the biology of pre-cancer in the bowel & want to translate biology for cancer prevention this one could be for you... funded by the brilliant #40tude

Data Scientist in Sutton | The Institute of Cancer Research View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £53,500 (Dependent on experience ) Reporting to: Professor Trevor Gra...

Calling cancer data scientists! 📊 💽 🧮
We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...

Epigenetically driven and early immune evasion in colorectal cancer evolution - Nature Genetics This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...

Congratulations Alvaro! And your exciting papers are following...

Ouse Valley Viaduct, Sussex, UK

🚨🚨🚨
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.

If you're excited about evolution, genomics and biomedical research, this is your DN! 😃

Further info: www.evomg-dn.eu and 👇

Both projects involve lots of collaboration, supervision, mentorship and training (& travel!) across our @evomg-dn.bsky.social network. They mandate motility across the #EU and partner countries too. Consequently I think the studentships will offer exceptionally rich #PhD experiences.

The second is about potential fitness costs of cancer drug resistance, and how we might exploit them using approaches like adaptive therapy. (building on our work with @mlockley.bsky.social in ovarian cancer: aacrjournals.org/cancerres/ar...). Description here: www.icr.ac.uk/study-and-ca...

The first is about developing new approaches to track cancer evolution from cell free DNA (cfDNA - liquid biopsy), and is a collaboration with industry partner nonacus.com Description here: www.icr.ac.uk/study-and-ca...

We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.

Big, beautiful trees!!

SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.

www.biorxiv.org/content/10.1...

Great flash talks from Anton Patrikeev (HPV evolution in head and neck cancer) and Florian Gabel (resistance evolution in prostate cancer) both from our @cec-icr.bsky.social @icr.ac.uk #CrickCancerConf

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

thanks Vijay!

Here's @calumgabbutt.bsky.social's nice thread on our #EVOFLUx paper in @nature.com that uses fluctuating methylation to track cancer evolution

Thanks Christian!

Epigenetic clues from cancer’s past foretell its future An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.

A nice news and views about the paper too: www.nature.com/articles/d41...

Thank you Pavlo Lutsik @kuleuvenuniversity.bsky.social & Veselin Manojlovic, George Vassiliou @cruk-ci.bsky.social

I'm really excited about this work: EVOFLUx tech means we can measure cancer evo at massive scale, even reusing old data. Truly joyful collaboration with brilliant @calumgabbutt.bsky.social Inaki Martin & Marti Duran @idibaps.bsky.social @imperialcollegeldn.bsky.social @qmbci.bsky.social @icr.ac.uk

With the wonderful Inaki Martin-Subero & Marti Duran @idibaps.bsky.social we applied the method (called EVOFLUx) to meth data from ~2000 lymphoid cancers, inferring cancer age, initial growth rate & other evo dynamics. This evolutionary history strongly predicted clinical outcome, especially in CLL.

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

This looks very cool... implementing mathematical models of cell and tissue biology from plain-text human readable statements. I want to have a play with it! Congratulations Paul @mathcancer.bsky.social and team

Congrats Kit! @yosoykit.bsky.social Extremely worthy recipient of the Leah Edelstein-Kehset prize #SMB2025: she is leading the way modelling disease progression to improve early detection and prevention of #cancer

smb.org/SMB-Awards

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disru...

Goldschmidt's hopeful monsters in cancer: single cell DNAseq shows whole genome doubling (WGD) is an ongoing and frequent mutational process in ovarian cancer. www.nature.com/articles/s41... beautiful work from @sohrabshah.bsky.social and team

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

Schmidt Fellows: if you're a #compbio #AI postdoc, feel free to drop me a line to discuss ideas and I can help you find host labs in the @icr.ac.uk

Postdocs in the USA who'd like to return to Europe to set up their own thing... these could be for you?

www.imperial.ac.uk/jobs/search-...