Trevor Graham

Great flash talks from Anton Patrikeev (HPV evolution in head and neck cancer) and Florian Gabel (resistance evolution in prostate cancer) both from our @cec-icr.bsky.social @icr.ac.uk #CrickCancerConf

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

thanks Vijay!

Here's @calumgabbutt.bsky.social's nice thread on our #EVOFLUx paper in @nature.com that uses fluctuating methylation to track cancer evolution

Thanks Christian!

Epigenetic clues from cancer’s past foretell its future An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.

A nice news and views about the paper too: www.nature.com/articles/d41...

Thank you Pavlo Lutsik @kuleuvenuniversity.bsky.social & Veselin Manojlovic, George Vassiliou @cruk-ci.bsky.social

I'm really excited about this work: EVOFLUx tech means we can measure cancer evo at massive scale, even reusing old data. Truly joyful collaboration with brilliant @calumgabbutt.bsky.social Inaki Martin & Marti Duran @idibaps.bsky.social @imperialcollegeldn.bsky.social @qmbci.bsky.social @icr.ac.uk

With the wonderful Inaki Martin-Subero & Marti Duran @idibaps.bsky.social we applied the method (called EVOFLUx) to meth data from ~2000 lymphoid cancers, inferring cancer age, initial growth rate & other evo dynamics. This evolutionary history strongly predicted clinical outcome, especially in CLL.

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

This looks very cool... implementing mathematical models of cell and tissue biology from plain-text human readable statements. I want to have a play with it! Congratulations Paul @mathcancer.bsky.social and team

Congrats Kit! @yosoykit.bsky.social Extremely worthy recipient of the Leah Edelstein-Kehset prize #SMB2025: she is leading the way modelling disease progression to improve early detection and prevention of #cancer

smb.org/SMB-Awards

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disru...

Goldschmidt's hopeful monsters in cancer: single cell DNAseq shows whole genome doubling (WGD) is an ongoing and frequent mutational process in ovarian cancer. www.nature.com/articles/s41... beautiful work from @sohrabshah.bsky.social and team

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

Schmidt Fellows: if you're a #compbio #AI postdoc, feel free to drop me a line to discuss ideas and I can help you find host labs in the @icr.ac.uk

Postdocs in the USA who'd like to return to Europe to set up their own thing... these could be for you?

www.imperial.ac.uk/jobs/search-...

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

Mathematical modelling of cancer cell evolution and plasticity In this review, we argue that mathematical modelling is an essential tool for understanding cancer cell evolution and phenotypic plasticity. We show t…

New review from @chloecolson.bsky.social on cancer evolution & plasticity from a mathematical modelling lens: www.sciencedirect.com/science/arti...

Chloe provides a framework to think about plasticity & evolution, & explains how maths models can reveal cell dynamics that we can't directly observe.

Advancing cancer research via comparative oncology - Nature Reviews Cancer Comparative oncology combines evolutionary biology, ecology, veterinary medicine and clinical oncology to better understand cancer, for example, by identifying the molecular and cellular mechanisms un...

Enjoyed this @natrevcancer.nature.com article on comparative oncology - how we can learn from other species 🐘🐋🦜🐍 about ways to prevent (& possibly treat) cancer. Both a review and a call to action for the research community. www.nature.com/articles/s41... @atjcagan.bsky.social @cmaley.bsky.social

Congratulations @vinaya-gunasri.bsky.social. Fantastic achievement, look forward to seeing your lab grow.

Closing keynote from the fabulous @atjcagan.bsky.social on "The impossibility of whales" discussing somatic mutagenesis across species. Brilliantly delivered and exceptionally illustrated talk, as anyone who knows Alex's work would expect! #EBECancer25
@eventswcs.bsky.social

Great press write up of @beckilee.bsky.social's DyNAMIC clinical trial, testing adaptive targeted therapy for melanoma with ctDNA guided decision making. The hope is that ctDNA guided treatment cessation and restart (potentially less drug, less often) will improve outcomes for patients.

Who were the ancient Egyptians?

It is expressed in the extraordinary historical and archaeological record, but what about ancestry links to other ancient individuals?

Today we report the successful sequencing of the whole genome of an individual who lived in Egypt about ~4700 years ago.

Now medical oncologist and clinician scientist @beckilee.bsky.social leading the first clinical session. Discussing how to bring evolutionary and ecological ideas into molecular tumour boards, and how to design evo clinical trials for better treatment regimens. #EBEcancer25 @eventswcs.bsky.social

This morning we switch focus to cancer ecology, starting with Marta Luksza @mskcancercenter.bsky.social lecturing on tumour-immune coevolution and immunogenomics. #EBECancer25

@amyboddy.bsky.social @afrankell.bsky.social @yosoykit.bsky.social @sangerinstitute.bsky.social @icr.ac.uk

Our Evolutionary Biology and Ecology of Cancer Summer School #EBECancer2025 in full swing @eventswcs.bsky.social in sunny Hinxton, Cambridge. @florentmouliere.bsky.social giving a deep dive into tracking cancer evolution with cfDNA. @amyboddy.bsky.social @yosoykit.bsky.social @afrankell.bsky.social

Thanks very much Alejo!

Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding - Nature Communications Understanding the dynamics of how drug resistance originates in cancer remains crucial, but it is not possible to observe them directly. Here, the authors construct a mathematical framework to infer d...

Using barcodes 📊 to track cancer 💊 resistance evolution: is it clonal selection or plasticity? @fwhiting.bsky.social‬ knows! His new "Evolutionary Informed Resistance Assays" (EIRAs) framework infers resistance evolution dynamics from barcode diversity data. www.nature.com/articles/s41... @icr.ac.uk

Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling - Nature Communications The authors show that aberrant epithelial GREM1 expression remodels intestinal stroma to form ectopic stem cell niches in mice. Anti-GREM1 reversed these changes, highlighting a potential strategy for...

Lovely new paper from @leedham-simon.bsky.social dissecting epithelium-microenvironment crosstalk through BMP & wnt signalling in the intestine. Inhibition of BMP antagonist GREM1 may forestall polyp formation in Hereditary Mixed Polyposis Syndrome (HMPS). www.nature.com/articles/s41...

Higher or Senior Scientific Officer in Sutton | The Institute of Cancer Research View details and apply for this Higher or Senior Scientific Officer vacancy in Sutton. Salary : Salary from 39,805 to 49,023 Reporting to: Prof Trevor Graham Duration of ...

Single cell whizz with green fingers for molecular genomics? Want to develop and apply new technologies for profiling #cancer #evolution? Like single cell WGS + ATAC: www.biorxiv.org/content/10.1...

Perhaps our senior scientific officer role is for you?

jobs.icr.ac.uk/vacancies/12...

@icr.ac.uk

Data Scientist in Sutton | The Institute of Cancer Research View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £49,023 (depending on the experience) Reporting to: Professor Trevor Graham ...

Calling data scientists: we have opening in our Data Science core @icr.ac.uk to lead work around cancer spatial biology and single cell analysis. These are staff scientist type positions, ideal for someone who wants to help drive computational research. Apply here: jobs.icr.ac.uk/vacancies/12...

Lemongrass sprouting update... now we have two plants and I confirm their leaves are delicious in a curry!