John Rubinstein

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1...

Very nice work! Congratulations!

This is very cool!

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

Congratulations @kev-in-situ-et.bsky.social and the whole team on in situ cryo-ET images of OA-induced mitochondria damage and Parkin-dependent mitophagy out now tinyurl.com/25b82cp4. We couldn't have done it without in situ guru @wilflinglab.bsky.social and mito guru @samlewis.bsky.social .‬

Sub-3 Å resolution protein structure determination by single-particle cryo-EM at 100 keV Cryoelectron microscopy (cryo-EM) has transformed structural biology by providing high-resolution insights into biological macromolecules. We report s…

Now out in Structure: Paper on high-resolution #cryoEM using the 100 kV Tundra cryo-TEM by Dimple Karia, Adrian Koh, @abhaykot.bsky.social, @lingboyu.bsky.social, @landerlab.bsky.social and many others. Happy to have contributed to this effort. Check it out:
www.sciencedirect.com/science/arti...

SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a pro...

This has a neat mechanism of inhibition:
www.nature.com/articles/s41...

Trump Administration Puts New Chokehold on Billions in Health-Research Funding The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.

NEW
The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year

Chokes off billions in research funding

Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social

Faculty (UWOFA) Western University, in vibrant London, Ontario, delivers an academic and student experience second to none.

Political Science at Western University, Canada is searching for three tenure track assistant professors. There are two ads, one in International Politics (IR or comparative) and one in Comparative or Canadian. Ads are here: www.uwo.ca/facultyrelat...

"In TAG’s view, the suspended TB studies do not pose a substantial risk to the American public in comparison with the clear and present danger of TB, which is the world’s leading cause of death from a single infectious agent."

www.treatmentactiongroup.org/statement/tr...

Photo of Tom Lehrer

My last living musical hero is still my hero but unfortunately no longer living. RIP to the great, great Mr. Tom Lehrer.

The black-and-white photograph shows two men, identified as Charles Best and Frederick Banting, seated side by side in a formal setting. Both are dressed in suits with ties, typical of early 20th-century professional attire. Charles Best, on the left, wears a three-piece suit with a patterned tie and has his hands clasped in front of him. Frederick Banting, on the right, is dressed in a darker suit with a striped tie and holds a pair of glasses in one hand while resting the other on his lap. Behind them is a wooden bookshelf filled with books and papers, along with a framed picture on the wall.

On this day in 1921, Dr. Frederick Banting and Charles Best successfully isolated the hormone insulin. They accomplished this at the University of Toronto. On Jan 11, 1922, 14-year-old Leonard Thompson became the first person to receive an insulin injection for diabetes.

And Stockholm is a great city! 🇸🇪

🇨🇦🚨Job alert🚨🇨🇦
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children

We are hiring 📣 Join our mighty team! See posting below 👇

www.sickkids.ca/en/research/...

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!

We are looking for creative, innovative scientists asking fundamental questions in any area of biology.

Join our vibrant, collaborative, and supportive community!

aprecruit.ucsf.edu/JPF05702

Wow, that brings back old memories from my PhD!

When particles have orientation bias, the resulting maps are often streaked along the missing directions. In this case study, we cover why orientation bias produces anisotropic #cryoEM maps and how you may be able to recover from it!

guide.cryosparc.com/processing-d...

Congratulations, Martin!

Very honored to receive this year's Byers Award in Basic Science!
Huge thanks to my lab and our funders for enabling our research on Alzheimer's disease and related dementias.

www.ucsf.edu/news/2025/07...

Congratulations, Eva!!

A unique honor to become a Foreign Member of the @royalsociety.org, together with my @ucberkeleyofficial.bsky.social colleague Stuart Russell and old friends like John Briggs, Asia Akhtar, Patrick Cramer or Ruth Lehmann. Learning about great science and science history was a real treat.

Fay: Cuts to research funding risk the collapse of U.S. science and technology I started as an assistant professor of molecular biology at the University of Wyoming in 2001.

Thanks to @isakoditomassi.bsky.social and the McClintock Letters Initiative who motivated me to submit this.

Checking out Toronto’s day-old park (Biidaasige Park) on my morning run. Beautiful in the morning sun.

Tucked away in the 'One Big Beautiful Bill' is the requirement that all visitors to the US must pay $250 just to enter the country starting 1 October! For a family of 5 that's $1250! I doubt this will help America's crashing tourism business which is down 10% already since January

Climate change doesn’t exist which is why parts of Canada can now support warmer weather plants (some regions are seeing a two zone shift).

Link here! guide.cryosparc.com/processing-d...

Working with symmetric or pseudosymmetric particles in #cryoEM?

This TRPV5 and CaM case study includes practical considerations for using symmetry relaxation and 3D classification when analyzing a pseudosymmetric particle in #CryoSPARC!

Are you a top US-based scientist wanting to relocate to Australia? We are now calling for formal applications from both Australian and non-Australian citizens based in the US whose work is internationally recognised as exceptional.
📅 Applications close: Aug 29, 2025
🔗 science.org.au/gtap/?utm_so...