Domokos Meszena

Interested in consciousness? Join the club. And join us tomorrow (noon on Zoom) for the first seminar of the MIT Consciousness Club.
sites.google.com/view/mit-con...

Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach? Despite advancements in implantable electrode technology, challenges persist in scaling up these devices to record most of the neuronal activity across the cortex. This review explores the limitation...

"Capturing the Electrical Activity of all Cortical Neurons:
Are Solutions Within Reach?" in Advanced Science, link to the paper: doi.org/10.1002/advs... 5/5

#neurotechnology #neuralinterfaces #iBCI #neuralink #invasive #electrophysiology #clinical #electrode #systemsneuroscience #highdensity

Although there has been some discussion about this recently (E.g., the #Science Corp. mentions it in their update: science.xyz/news/biohybr... ), we are making the first attempt to systematically assess the BN of the best available probes (high-density rigid, flexible, and biohybrid electrodes). 4/5

In close connection with this, we are introducing the term “ #Butcher_Number ” in the literature as a valuable parameter for assessing insertion-related damage and acute recording quality (first mentioned by #Markus_Meister @mameister4.bsky.social whom we thank for the term in the paper). 3/5

But scaling this is far from trivial. What are the theoretical and practical limits for #BCIs interfacing with the neural tissue? We are exploring this in our recent review, led by #Gergely_Katona (co-first-authored by #Attila_Kaszas and me), together with other brilliant members from our lab. 2/5

Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach? Despite advancements in implantable electrode technology, challenges persist in scaling up these devices to record most of the neuronal activity across the cortex. This review explores the limitation...

As we saw in the latest #Neuralink Summer 2025 update, the more electrodes we have, the more neurons can be recorded. They are planning to implant into multiple brain regions, ultimately aiming to reach every cell in the whole brain.
1/5

High–resolution laminar recordings reveal structure–function relationships in monkey V1 The relationship between the structural properties of diverse neuronal populations in the monkey primary visual cortex (V1) and their functional visual processing in vivo remains a critical knowledge ...

On behalf of Nicole Carr: new preprint from the Chand/Moore labs! High-resolution laminar recordings reveal structure-function relationships in monkey V1.

1/4

www.biorxiv.org/content/10.1...

Is the word pope not P.O.P.U.S in Latin, by any chance?:)

Optimizing electrode placement and information capacity for local field potentials in cortex https://www.biorxiv.org/content/10.1101/2025.04.25.650658v1

Optimal inter-electrode distances for maximizing single unit yield per electrode in neural recordings https://www.biorxiv.org/content/10.1101/2025.04.11.648355v1

Learning and language in the unconscious human hippocampus Consciousness is a fundamental component of cognition, but the degree to which higher-order perception relies on it remains disputed. Here we demonstrate the persistence of learning, semantic processi...

New paper from the Neurosurgery Research Team at BCM! "Learning and language in the unconscious human hippocampus"
www.biorxiv.org/content/10.1...

The coolest result, IMO, is active prediction of upcoming words in the sequence, suggesting that hippocampus is involved in the process of using information about current words to predict future words, even in the absence of consciousness.

DREDge: robust motion correction for high-density extracellular recordings across species - Nature Methods DREDge is a software tool for motion correction of high-density electrophysiology recordings. It can handle action potential or local field potential data and is demonstrated on a variety of acute or ...

Incredible effort from a massive team led by Charlie Windolf and Erdem Varol to develop DREDge motion correction algorithm of high resolution neural data across species including humans is finally out in Nature Methods! It was an honor to be involved! www.nature.com/articles/s41...

DREDge is a software tool for motion correction of high-density electrophysiology recordings. It can handle action potential or local field potential data and is demonstrated on a variety of acute or chronic recordings from humans, nonhuman primates and mice.

www.nature.com/articles/s41...

All Credit goes to first and last authors, I am just a co-author:) thank you for reposting!

On the longevity and inherent hermeticity of silicon-ICs: evaluation of bare-die and PDMS-coated ICs after accelerated aging and implantation studies - Nature Communications Silicon ICs are key to neural implants but face reliability challenges. Here, the authors show bare die ICs can be inherently hermetic, and PDMS encapsulation limits degradation over 12 months, offeri...

Here, our team have conducted the longest and most thorough evaluation available on the electrical and material performance of chronic implantable bare-die and PDMS-coated CMOS chips.

www.nature.com/articles/s41...

It was an honour to contribute even a little bit to this project and to work in this awesome collaboration! If you are interested in the packaging, accelerated aging, and biocompatibility of neural implants, check out our new paper!

Could you please add me, if still possible? We are doing high-density in vivo human Neuropixels recording in the OR!:) thanks!

Could you please add me as well, if still possible? We are doing high-density intraoperative Neuropixels recordings in human, single unit, LFP, cognitive tasks all involved, thanks!

I would like to join too, working on human in vivo single unit and LFP analysis!:)