New layer-fMRI preprint capturing the spatial variability of layer-profiles for a simple visual stimulation.

By Blazejewska et al
doi.org/10.1101/2025...

New layer-fMRI preprint using simultaneous layer-fMRI with EEG at 7T. Establishing an acquisition and analysis setup to capture layer-fMRI correlates of spontaneous alpha power variations.
By Marsh et al.
doi.org/10.1101/2025...

There is going to be an exiting workshop on advanced fMRI end of October in Erice, Sicily (Italy).

The agenda looks just at great as the location.

ismrbf.marbilab.eu/events/7-xiv...

New manuscript that uses layer-fMRI to investigate the brain mechanism of afterimages.
By @sharifkronemer et al.,
doi.org/10.1101/2025...

2/2
Häkkinen et al., investigated how to push layer-fMRI VASO at the next-Gen 7T (Feinbergatron) 7T scanner for layer-specific circuitry mapping. The fast gradients reveal temporal dynamics and connectivity with the cortex.
doi.org/10.1101/2025...

Two exciting new manuscripts on layer-fMRI VASO in the Hippocampus:

1/2
Ahmadi et al. focuses on the biophysical challenges and how to account for them. They show the feasibility of laminar specific VASO- disseminated across multiple clinical 7T scanners.
doi.org/10.1101/2025...

YouTube video by Sam Torrisi OHBM 2021 SurfLayers abstract video

From a few years ago but it disappeared off yt so I recently re-uploaded. SurfLayers demo. #tbt youtu.be/Py0a8O2h-gc?...

The potential of laminar functional MRI in refining the understanding of epilepsy in humans Aitken et al. highlight laminar fMRI as a tool to connect the neural effects of anti-seizure medications with the microcircuits that generate seizures in e

Our review discussing the potential use of laminar fMRI for probing the role of cortical layers in epileptic seizure propagation and spread as well as it possible future clinical applications out in Brain (well as accepted manuscript!)

academic.oup.com/brain/advanc...

This thread reminds me on a satirical Blog post on this issue.
layerfmri.com/the-best-seq...

Maybe this one fits best here on the topic of bing noisy.

Thanks. I am glad we agree that the replication discussion was not about VASO then.

Kenshu Koiso (movies + newly faces/places), Insub Kim (orientation), Daniel Haenelt (ODC) compared MVPA across contrasts. Their results agree with you on vein effects in MVPA BOLD.

No 🌌 left, DM 4 🔗.

Fully agree. There was a slide on one of the layer-fMRI educationals at OHBM trying to get an overview of the layer field.
Attention (or what people call it to be) seems to be the least reproducible effect in the field.

It's not so easy.
It depends, if reduced sensitivity is coming from removing fasle-positive vein signals. VASOs sensitivity to micro vessels is not bad and often used for MVPA
Wasn't the replication issue in that study discussed wrt segmentation issues. If at all, VASO's T1 contrast helps with that

Hence use VASO :-)

For the laminauts. @layerfmri.bsky.social

Happy to see this out: our new preprint shows that laminar GE-BOLD fMRI decoding isn’t immune to vascular draining biases. Simulations reveal false positives due to multivariate signal spread across layers, but oversampling + deconvolution can (sometimes) improve specificity.

New layer-fMRI preprint looking at laminar response differences of across (very) early development in newborns.
Exciting new directions in the field.
By Moore et al.
doi.org/10.1101/2025...

This is a really nifty tool. Great to have it working for the lastest MacOS versions. Thanks Pete

New layer-fMRI paper investigating the microcircuitry of proprioception by comparing laminar fMRI profiles during active and passive finger movements.
By Knudsen et al.
doi.org/10.1093/cerc...

I’m proud to share that on July 3rd, I defended my PhD thesis: "Distinct and complementary: insights on bistable perception in humans using ultra-high field MRI across multiple spatial scales."

The defense stream is here: youtube.com/live/J7wmn5s...

Excited for what’s next!🧠🧲🥳

New layer-fMRI post doc position for methods development of high-res fMRI in the human Hippocampus.
In Tübingen with Klaus Scheffler, Jonas Bause and Svenja Brodt
layerfmri.wordpress.com/wp-content/u...

A series of talks on 7T (f)MRI from the SIEMENS UHF user meeting in Frankfurt are now online:
www.magnetomworld.siemens-healthineers.com/clinical-cor...

Spatial specificity of the functional gradient echo and spin echo BOLD signal across cortical depth at 7 T Functional magnetic resonance imaging (fMRI) at high magnetic field strengths (≥ 7 T) is a promising technique to study the functioning of the human brain at the spatial scale of cortical columns and ...

I’m happy to share that our manuscript on the cortical depth-dependency of the GE- and SE-BOLD point spread function at 7 Tesla is now available on bioRxiv!

www.biorxiv.org/content/10.1...

The Minnesota ultra-high-field meeting will again offer the popular hands-on layer-fMRI analysis pre-workshop on practical aspects.
October 13th-14th 2025.
Registration: sites.google.com/umn.edu/2025...

Next week there is going to be an exciting virtual workshop from the ISMRM brain function group: Studying Brain Function in Fetuses, Newborns and Infants.
Next Wednesday. Zoom link in the QR code

This is a nice new study showing the mechanisms why CBV fMRI is so specific to cortical layers:
The somatostatin neurons are driving the hemodynamic response at fMRI-typical time scales.
By Vo et al, from Seong-Gi Kim's lab.
doi.org/10.1038/s414...

New layer fMRI book chapter on the value of layer-fMRI for understanding psychiatric disorders.

by J Haarsma and P Kok @jhaarsma.bsky.social @peterkok.bsky.social

doi.org/10.1007/7854...

I've always wanted to explore fMRI time series as a smooth, real-time movie. Now I can with LayNii IDA. Plus, with voxel-wise correlations on the fly.

Fast, intuitive, and surprisingly insightful.

40 ms TR fMRI data from @practicalfmri.bsky.social !

@layerfmri.bsky.social @afni-pt.bsky.social

New layer-fMRI preprint by Clauner et al.

Interleaved EEG and layer-fMRI is used to investigate feature-specific and unspecific correlates of alpha and gamma oscillations in superficial and deeper layers.

doi.org/10.1101/2024...

New high resolution fMRI paper describing the capabilities and challenges of 9.4T fMRI in the cerebellum.
By van der Zwaag et al., (@highonfield.bsky.social, @nikospriovoulos.bsky.social)

doi.org/10.1002/mrm....

New layer-fMRI study:
Combined GE and SE BOLD captures mirrored finger representations in human motor cortex.
By SoHyun Han et al.,
doi.org/10.1016/j.ne...