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Felix Pahmeier

@fpahmeier.bsky.social

PhD Candidate - Infectious Diseases and Immunity

70 Followers  |  267 Following  |  1 Posts  |  Joined: 16.01.2024  |  1.5308

Latest posts by fpahmeier.bsky.social on Bluesky

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Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social‬, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...

20.05.2025 18:19 β€” πŸ‘ 58    πŸ” 20    πŸ’¬ 1    πŸ“Œ 1
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Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread Glycoprotein GP38-specific antibodies reduce viral dissemination and GP38-mediated vascular leak in Crimean-Congo hemorrhagic fever virus infection.

Happy to finally see this study published, a great collaboration between academic, government and industry labs! We show that CCHFV GP38 can induce vascular leak and that this can be prevented by protective but not virus-neutralizing antibodies! www.science.org/doi/10.1126/...

19.02.2025 23:31 β€” πŸ‘ 9    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes Crimean-Congo hemorrhagic fever virus is a widespread tickborne virus that infects humans. Engineering-based structural studies of the viral glycoprotein complexes GP38-Gn and GP38-Gn-Gc provide insights to their function in the viral life cycle. GP38-Gn-Gc confers partial protection against lethal viral challenge in mice, showing promise as a vaccine antigen for further development.

I'm happy to announce that our paper is now online in Cell! This study was the result of a highly collaborative effort from many scientists. Please read it here: www.cell.com/cell/fulltex...
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20.12.2024 20:01 β€” πŸ‘ 16    πŸ” 11    πŸ’¬ 1    πŸ“Œ 1
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A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice The continued emergence of SARS-CoV-2 variants and the threat of future Sarbecovirus zoonoses have spurred the design of vaccines that can induce broa…

"A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice"

www.sciencedirect.com/science/arti...

18.11.2024 19:07 β€” πŸ‘ 16    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

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