Long-Term Outcomes in Nephrotic Syndrome by Kidney Biopsy... : Journal of the American Society of Nephrology sociated with good kidney outcomes at 10 years.Monogenic nephrotic syndrome cases had very high proteinuria and rapid progression to kidney failure with little response to current treatments. Backgro...

Great paper from UK RaDaR dataset on outcomes in adult and childhood nephrotic syndrome

journals.lww.com/jasn/fulltex...

A stylized representation of the unmet need in a typical adult patient with IgA Nephropathy #IgAN ca. 2024
#ERA25 🇦🇹 #Nephpearls #NephSky

👉 pubmed.ncbi.nlm.nih.gov/39211339/

10 years of SGLT2i trials shared by Dr Kaitlyn Mayne at #era25!

Disease-modifying anti-nephropathic drugs (DMANDs)—a definition proposed by the Immunonephrology Working Group (IWG) of the European Renal Association (ERA) ABSTRACT. A definition of ‘disease modification’ for kidney disease is long overdue. Here, we propose three key criteria for disease modification in immune

Disease-modifying anti-nephropathic drugs ‘DMANDs’ in NDT this month

@ndt-era.bsky.social

The right drug for the right patient…that’s how we keep changing the story for patients with kidney disease

academic.oup.com/ndt/article/...

YouTube video by Ottawa Nephrology Foundation therapies for heart failure in end stage kidney disease with Dr Matt Graham-Brown

Foundational therapies in ESRD for heart failure

Dr Matt Graham-Brown from Leicester presents at #NephGR

www.youtube.com/watch?v=Ar11...

(Rounds from Feb, late share!)

Frailty in Adults with Chronic Kidney Disease and... : Clinical Journal of the American Society of Nephrology aim was to validate KFRE by frailty status and assess whether model performance could be improved by using cystatin based estimated glomerular filtration rate (eGFR) equations and to assess the impact...

KFRE underestimates risk in people with CKD and frailty

journals.lww.com/cjasn/abstra...

Blood pressure measurement technique in clinical practice in the NHS Greater Glasgow and Clyde - PubMed Blood pressure (BP) measurement is a common procedure conducted in various disciplines and is widely available on clinical reports. The diagnosis and management of hypertension require reliable measur...

The remaining challenge is measuring BP by standardized method. Very few clinics can do it in Scotland. Is the same true in Canada? pubmed.ncbi.nlm.nih.gov/39638870/

That’s what we just did in Canada! Target is SBP < 130 mmHg for all

www.cmaj.ca/content/197/...

So we should remove diastolic targets from guidelines no? @hswapnil.medsky.social

A randomized controlled trial of intravenous immunoglobulin vs standard of care for the treatment of chronic active antibody-mediated rejection in kidney transplant recipients

doi.org/10.1016/j.kint.2025.04.023

#NephSky #MedSky @dialysisbloke.bsky.social #kidneytransplant #KTx

It is not lack of capacity driving this in Scotland. It is patient choice.

Aspirin Continuation or Discontinuation in Surgically Treated Chronic Subdural Hematoma The SECA randomized clinical trial assesses the risk of recurrence of chronic subdural hematoma (cSDH) and cardiovascular events in patients undergoing surgical treatment for cSDH with continuous vs discontinuous low-dose acetylsalicylic acid treatment.

Discontinuing aspirin during surgery for chronic subdural hematoma did not lower recurrence rates compared to continuous treatment.

by Kamenova M, Pacan L (...) Soleman J et 9 al. in JAMA Neurol #MedSky

👉 get more here

📖 read the article:

Come to #ERA2026 in Glasgow @hswapnil.medsky.social . It will be a great meeting and we will make you very welcome.

#archive30 #day24

It's very hard to choose 😵‍💫

But this is a pretty #popularitem - an original X ray tube

Plus the man who set up the world's very first X ray department in 1896 at #glasgowroyalinfirmary our medical electrician Dr John McIntyre ❤️

@arascot.bsky.social

Why Health Guidelines Should Be Waged Like War Updated Here's a modest proposal: we need fewer and shorter guidelines. In fact, I'd like to propose that guidelines, like war, should be waged only when there is absolute consensus and overwhelming e...

This seems like a - let us write more guidelines that will get heavily cited and boost my h-index - piece

I will argue we need less guidelines

They should be like wars - waged only when absolutely necessary (stealing from @cardiobrief.bsky.social Larry Husten www.forbes.com/sites/larryh...)

Longest human transplant of pig kidney fails In latest xenotransplant test, Towana Looney’s body rejects gene-edited organ after more than 4 months

Exclusive: Towana Looney, a 53-year-old woman who received a kidney from a gene-edited pig on 25 November 2024, had it removed last week after the organ suddenly stopped functioning, Science has learned. scim.ag/3EiaJmM

Sleep duration histogram

Overall they sleep poorly
Median ~ 6.5 hours - and look at the spread
2/

Very interesting pilot trial from @bhanu24.bsky.social and colleagues in @ajkd.bsky.social

Renal Denervation in .....loin pain hematuria syndrome!

www.ajkd.org/article/S027...

#NephSky

Screenshot of resignation letter

Screenshot of resignation letter

Screenshot of resignation letter

Nearly all patient representatives on the Organ Procurement and Transplantation Network board have resigned. #MedSky

hyponatremia: serum sodium tells us where you are and urine osm/lytes tell us how you got there

👏👏

Venous Thromboembolism in Primary Nephrotic Syndrome - Is the Risk High Enough to Justify Prophylactic Anticoagulation? - PubMed Patients with primary NS are at an increased risk of VTE. The timing of VTE means that only half of episodes would be targeted by prophylactic anticoagulation. Given the low frequency of events, a wel...

Contrary to other studies we observed highest incidence of thrombotic events in min change but we analysed events per month of NS. So maybe nothing special about membranous other than NS is sustained for longer than other causes? pubmed.ncbi.nlm.nih.gov/27669572/

Could it be that higher incidence of thrombotic events in the first 6m is because some NS scenarios involve imbalance of protein loss in favour of thrombosis and some don’t? So what remains after a few months is latter (who by implication will be harmed by anticoag because they never needed it)

We’re no further forward after 30 years of debate. Producing detailed treatment algorithms based on flawed observational evidence makes the RCTs the authors cry out for less likely to happen. Recommending a “Highly personalised” approach is code for “we don’t know”.

#archive30 #day3 #soundandvision

#musicinthegri our concert series, a wonderful project instigated & led by Arthur Doyle, a man who definitely has vision & makes some wonderful sounds on his violin.

The last concert in GRI was in1883; recitals were a common means of raising £ in the days pre #nhs

Anti-Nephrin Antibodies in Adult Chinese Patients with Minimal Change Disease and Primary Focal Segmental Glomerulosclerosis

doi.org/10.1016/j.kint.2025.02.028

#NephSky #MedSky #minimalchangedisease #FSGS #IgG #IgM #focalsegmentalglomeruloscelrosis

Anticoagulation for Patients with Atrial Fibrillation... : Journal of the American Society of Nephrology agulation (n=48).Despite coronavirus disease–related pauses, recruitment was completed in 30 months, with 83% of participants completing follow-up in their assigned treatment arm. Background Atrial...

Delivering a trial with adequate power to answer the question of anticoagulation and AF should now be a priority for the nephrology community. journals.lww.com/jasn/abstrac...

Haven’t entered for #nephmadness for couple of years as Twitter toxic. Really enjoyed entering for 2025. Excellent CME. Great work as ever from all involved. mild dismay at infiltration of “… up to x%” instead of “approximately x%” from general journalism in to nephrologist prose. up to x = 0 to x 🫣

Vertragsbeendigung

5 minute resting + 60 seconds between measurements is the current standard for Blood Pressure

Could 3 minutes resting + 30 seconds between measurements also work? from @spjuraschek.bsky.social et al

🔗 academic.oup.com/ajh/article/... 🔓

#OpenAccess #Free