patternAlchemist

Defeating Nondeterminism in LLM Inference Reproducibility is a bedrock of scientific progress. However, it’s remarkably difficult to get reproducible results out of large language models. For example, you might observe that asking ChatGPT the...

Thinking Machines wrote a superb blog post on determinism in LLMs and it is fascinating (if you like computer architecture otherwise you’re going to tear your hair out)

spoiler: did you know GPUs have instructions that aren’t deterministic?

thinkingmachines.ai/blog/defeati...

Let’s continue with the fresh new Greenland series 🙂.
Pastel late sunset with mountain style iceberg in background & our beautiful red sails 😌.

Henry has long been emphasizing that representative democracy is a method of thinking and decision-making, not just a way of extracting fixed preferences from a populace.

SCOTUS has at no point indicated a willingness to subvert the constitution, despite conservative sentiments. Robert’s especially has consistently prioritized procedural and institutional continuity

Agreed it was a crisis. But the institutions are stronger than you’re giving them credit for. Also they weren’t taking orders from them although the VP, although acting SecDef did call and consult w pence and speaker

That would’ve been a much darker day but play it out - say they get control and stop the proceedings. You actually think it would work out and all the institutions would buckle including the courts?

Ha. I’ll admit w Vance instead of Pence J6 looks much darker. But surely you’d admit a constitutionally blocked 3rd term is a different animal than overturning a reelection bid? His campaign would never get off the ground

I mean Trump certainly stoked the flames but you wouldn’t dispute those far right groups weren’t already willing and mobilizing?

the system was stress tested and passed. Despite the bad optics & rhetoric we were never close to an *actual* constitutional crisis. I’ll admit another stress test is within the realm of possibility, but I’d argue the inevitability of violence requiring removal from office is beyond a stretch

Yes, for one that was largely supporter outrage over losing the reelection. Running for a 3rd constitutionally barred term is an entirely diff prospect. Also the court has already demonstrated willingness to rule against Trump especially Roberts. Finally, J6 is proof of my argument -

Out of curiosity, what would you put the odds out of 100 that we see actual violence? That Trump/Vance make an actual autocrat play?

Op did, but otherwise agree here

Appreciate the pushback but I’m aware of sham autocrat elections. Institutional strength, redundancy, and breadth is one of America’s greatest strengths. This isn’t completely impossible but if we’re being honest sits more as fanfic than forecast. The “inevitable” narrative is especially hyperbolic

Looking upwards from a dense forest carpet of young pines into red/brown pine trees stretching up and away from the viewer.

Sometimes when you take a new path through the forest it peters out and you're left in dense woodland. Often though, you get a fine view for your efforts. I'm sure there's a life metaphor in there somewhere. 😀

#hiking #nature #photography #ForestFriday #EastCoastKin #Ireland

You actually believe is Trump passed tomorrow Vance would serve indefinitely and there wouldn’t be a 2028 election…? Conspiracy theory central here let’s come back to reality. Constitution, military brass, and yes even Trump appointed judges aren’t letting that happen

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

AlphaFold is amazing but gives you static structures 🧊

In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃

Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...

🔥 Benchmark Alert! MotifBench sets a new standard for evaluating protein design methods in motif scaffolding.
Why does this matter? Reproducibility & fair comparison have been lacking—until now.
Paper: arxiv.org/abs/2502.12479 | Repo: github.com/blt2114/Moti...
A thread ⬇️

📢📢 "Proteina: Scaling Flow-based Protein Structure Generative Models"

#ICLR2025 (Oral Presentation)

🔥 Project page: research.nvidia.com/labs/genair/...
📜 Paper: arxiv.org/abs/2503.00710
🛠️ Code and weights: github.com/NVIDIA-Digit...

🧵Details in thread...

(1/n)

RFDiffusion2: a diffusion model that scaffolds enzyme active sites at the atomic level enables the generation of functional de novo enzymes

www.biorxiv.org/content/10.1...

Excited to share our preprint “BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design” — a collaboration with
@martinpacesa.bsky.social, @Zhidian Zhang, @Bruno E. Correia, and @sokrypton.org

🧬 Code will be released in a couple weeks

Protein function often depends on protein dynamics. To design proteins that function like natural ones, how do we predict their dynamics?

@hkws.bsky.social and I are thrilled to share the first big, experimental datasets on protein dynamics and our new model: Dyna-1!

🧵

The phrase "pathologically disorganized" is used to describe a neural network trained to predict protein structure from sequence embeddings

A post by @ncfrey.bsky.social and @amyxlu.bsky.social on repurposing ESMFold for protein design, featuring one of my favorite phrases in the field ncfrey.substack.com/p/hit-the-vi...

Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @minhuanli.bsky.social and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.

@science.org Cryo-EM reveals mechanisms of natural RNA multivalency | Science www.science.org/doi/10.1126/...
#RNAsky #RNAbiology #Cryo-EM

Awakening valley in the French Alps, with the Mt Blanc massif in background 🏔️

#photography #mountains #nature #art #landscape

A sign in front of paper bags that says, "Please have your nuts weighed at register during checkout."

And now I'm not allowed in the store anymore.

Btw, that scale was very cold.

I think there’s obviously a difference & continuum from pronouns, dress to more permanent changes. But as long as a professional is involved and it’s over time I don’t have a strong opposition at all. Let people be live authentically

I don’t feel strongly about that part compared to the prisons. Shouldn’t have included it. If they want to transition with guidance from doctors and maybe parents, I don’t support denying them that