Greg Bowman

Hate talk and a Christ-centred life do not, and have never come from the same well.

Kitten cage match!

YouTube video by CultRepo (formerly Honeypot) Python: The Documentary | An origin story

such an amazing documentary: www.youtube.com/watch?v=GfH4...

Being ridiculously cute is exhausting!

Night Sky on Mars

#nasadailyupdates

Adriatic NMR 2025 Adriatic NMR Conference 2025. Adriatic NMR Conference will take place at Imperial Park Hotel, Vodice, Croatia, from 18 to 20 September 2025.

Adriatic NMR Conference, with workshop: NMR Wine Profiling, September 18–20, 2025, Vodice, Croatia adriatic-nmr-conference.hkd.hr
#NMRevents #NMRchat #NMR 🧲

Our Brain—Immune Axis Gets A Jolt Facts, data and analytics about biomedical matters

A rundown on the big advances we’re seeing on the brain-immune axis

erictopol.substack.com/p/our-braini...

Congrats! Great work

Navigating protein landscapes with a machine-learned transferable coarse-grained model - Nature Chemistry The development of a universal protein coarse-grained model has been a long-standing challenge. A coarse-grained model with chemical transferability has now been developed by combining deep-learning m...

Our development of machine-learned transferable coarse-grained models in now on Nat Chem! doi.org/10.1038/s415...
I am so proud of my group for this work! Particularly first authors Nick Charron, Klara Bonneau, Aldo Pasos-Trejo, Andrea Guljas.

BioEmu now published in @science.org !!

What is BioEmu? Check out this video:
youtu.be/LStKhWcL0VE?...

Fossilized coral I found at the beach by Calvert Cliffs. Highly recommend!

Hosts fireworks 😀

I repeated what Penn told me without reading more, poor choice on my part

Kind of a misleading headline. Penn just follows NCAA guidelines, which means they allowed the swimmer a few years ago and wouldn't now. So maybe lets keep our anger at the real a* holes driving this:)

Made this cat beaker for my science and cat loving 9yo😀

Assistant, Associate, or Full Professor in BioChemistry University of California, Merced is hiring. Apply now!

🚨JOB ALERT🚨 open rank position in Biochemistry apply now: aprecruit.ucmerced.edu/JPF01995 #ChemSky do your thing, repost please!

Excited to share about new experimental structures of the coronavirus spike protein that confirm predictions we made early during the COVID-19 pandemic! Congrats to former student Max Zimmerman and the rest of the team at Generate Bio
foldingathome.org/2025/06/26/e...

Look what my lab got me for Father’s Day!

Thanks for your enthusiasm about FAH😀 Didn't mean to ignore you, I was taking a break from social media for a bit. Plugging back in will hopefully help. We also have some new features coming to the client software. Happy to hear any suggestions you or others have.

Before and after for my latest gardening project (I build walls, Angela plants things)

Excited to share our latest paper on @natcomputsci.nature.com‬! We present MEMnets, a deep learning framework for coarse-graining protein dynamics, driven by an analytical statistical mechanics theory to minimize memory kernels. Congratulations to all the authors! @uwmadisonchem.bsky.social

Antiviral unveiled that goes after multiple coronaviruses Open-science consortium discloses its lead candidate to fight SARS-CoV-2 and MERS-CoV

Antiviral unveiled that goes after multiple coronaviruses: Open-science consortium discloses its lead candidate to fight SARS-CoV-2 and MERS-CoV. cen.acs.org/acs-news/acs...

Its too hard to tell what's real right now for April Fools' jokes to sound fun...

Just one week left! Please consider submitting an abstract to our Pacifichem 2025 @pacifichem.bsky.social symposium on machine learning for biomolecular dynamics. Deadline: April 2!

At least not 2 more grant proposals

Enzyme Enhancement Through Computational Stability Design Targeting NMR-Determined Catalytic Hotspots Enzymes are the quintessential green catalysts, but realizing their full potential for biotechnology typically requires improvement of their biomolecular properties. Catalysis enhancement, however, is often accompanied by impaired stability. Here, we show how the interplay between activity and stability in enzyme optimization can be efficiently addressed by coupling two recently proposed methodologies for guiding directed evolution. We first identify catalytic hotspots from chemical shift perturbations induced by transition-state-analogue binding and then use computational/phylogenetic design (FuncLib) to predict stabilizing combinations of mutations at sets of such hotspots. We test this approach on a previously designed de novo Kemp eliminase, which is already highly optimized in terms of both activity and stability. Most tested variants displayed substantially increased denaturation temperatures and purification yields. Notably, our most efficient engineered variant shows a ∼3-fold enhancement in activity (kcat ∼ 1700 s–1, kcat/KM ∼ 4.3 × 105 M–1 s–1) from an already heavily optimized starting variant, resulting in the most proficient proton-abstraction Kemp eliminase designed to date, with a catalytic efficiency on a par with naturally occurring enzymes. Molecular simulations pinpoint the origin of this catalytic enhancement as being due to the progressive elimination of a catalytically inefficient substrate conformation that is present in the original design. Remarkably, interaction network analysis identifies a significant fraction of catalytic hotspots, thus providing a computational tool which we show to be useful even for natural-enzyme engineering. Overall, our work showcases the power of dynamically guided enzyme engineering as a design principle for obtaining novel biocatalysts with tailored physicochemical properties, toward even anthropogenic reactions.

Our latest paper "Enzyme Enhancement Through Computational Stability Design Targeting NMR-Determined Catalytic Hotspots" now out in JACS @jacs.acspublications.org. Collaboration with Jose M. Sanchez-Ruiz in Granada, among others. pubs.acs.org/doi/full/10....

Visual graphic of membrane protein simulation

#FlatironCCB scientist @sonyahanson.bsky.social was a guest editor for the Journal of Physical Chemistry B's new Membrane Protein Simulations Special Issue. Read here: pubs.acs.org/toc/jpcbfk/1... #science #biology

Yea, curious what that is…

Glad to see general medical science and infectious disease are there

"Funding from the NIH was contributed to 354 of 356 drugs (99.4%) approved from 2010 to 2019 totaling $187 billion"

Reference: jamanetwork.com/journals/jam...