Taco subo

I’m at the point where the best way to find amyloid in an echo is: if your amyloid sense is tingling off the plax, run the ekg thru @cardslab.bsky.social ai, if it’s over 20%, call it. Running strain and rwt isn’t worth the squeeze. Would love all 3 but our lab is stuck in 1999 #echosky #cardiosky

My chats with patients basically boil down to, waiting seems to increase stroke risk and you’re probably not going to stay asymptomatic for years anyway so might as well just pull the tavr trigger now. Maybe we need a doac v early tavr trial powered for cva

Oh ok. I don’t put on my critical thinking hat for non cardiology trials. Guess the grass isn’t that much greener

He’s probably mad about hospitalizations in the endpoint. Fair point. I’d like to see total hospitalizations. Concern that irrrversible fibrosis occurs while waiting and you wind up with worse chf after you eventually get the tavr. Don’t know why evolved trial didn’t look at 30 month ecv

What was wrong with early tavr?

Teclistamab–Daratumumab in Relapsed or Refractory Multiple Myeloma | NEJM Select an option below:

Hr of 0.17! Gives me med specialty envy #cardiosky #medsky #oncsky

63 seconds in the video they snort cocaine off a toilet seat

Yah and if you use 0.4 eroa as your cut point (like my institution), there’s not too many patients that get so massively remodeled that you don’t label them as disproportionate

If it doesn’t get approved, there will be 0 confidence that decision was made fairly

They opened the dnc with a land acknowledgement last August. Feels performative. it’s gonna come down to primaries in 27 if they go the Bernie aoc route or something less appealing. Until then. Don’t think they’ll have a central message

FDA will now review flu vaccine it had rejected - Axios

So does Moderna carry through with its no vaccine true threat?

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They need less land acknowledgment and more m4a/ climate action

Colbert Says CBS Pulled Senate Candidate Interview

Seems like a tempting loophole here. If you have to give equal time, just give 10 minutes to the QAnon shaman or some other whack job

Colbert Says CBS Pulled Senate Candidate Interview www.nytimes.com/2026/02/17/b...

Doesn’t seem there was ever a consensus on this from the teer trial meta analyses. I see a lot of chatter clinically on the lvef and lv volumes since the mitra-fr apparently had big low ef ventricles. They also had Eroa 0.31 on average. Way lower than anything I’ve ever referred

I would. Have had patients rejected when their ef is super low like <10%

Detecting Transthyretin Cardiac Amyloidosis With Artificial Intelligence This nonrandomized clinical trial reports the development and evaluation of an artificial intelligence–augmented screening program designed to detect transthyretin cardiac amyloidosis.

Point goes to the robots. 250 amyloid patients flying under the radar, picked up by mass ecg screening. Nnt for tafamidis is 7.5 so that’s 40 lives saved. 👍 they set their screen threshold at 50%. Way too high a bar. Gonna miss most patients. I use 10%.

Would be more interesting to see prognosis of amyloid positive carpal tunnel biopsy. Cleveland data suggests very few of these get systemic amyloid in the near term

I would enjoy not having to ask family history

Me: have your parents or siblings had any heart attacks before age 65?

Patient: well my grandmother had high blood pressure

I don’t know how genetic counselors keep their wits

Took me a second, this one

Classic mandrola. Always bitching about absolute treatment effects being too small. By his logic , every downhill skier would tie because winning by a few milliseconds isn’t big enough a win. Medicine is a game of inches. You take a rrr of 20% here, 15% there, eventually it all adds up

Hfref not hfpef in this trial but I feel like it’s worth bayers money. I only prescribe finerenone if the patients hit their $2000 copay max and I even prescribe Vericiguat. I don’t need all cause mortality reduction, I’d take a win ratio stacked with qol and biomarkers. I’m a cheap date

If the Dow makes it to 60000 dollars, Does trump get to go on a murder spree?

If ticsgrelor v prasugrel trials are getting done, seems like there’s a chance we may see finerenone v. Eplerenone

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ChatGPT it

Glad we’re getting outcomes trials. Boston scientific could have just taken the fda approval and left it at that

Oral Semaglutide and Heart Failure Outcomes in Persons With Type 2 Diabetes This secondary analysis of a randomized clinical trial evaluates the effect of oral semaglutide on heart failure events, major adverse cardiovascular events, and safety among participants with or with...

Posted this a few times already but one other pearl: no interaction between treatment effect and bmi. Paves the way for glp1a tx in the bmi<30 hfpef crowd

I always know I’m fucked when the consult gets placed