Nixa Sedes, MD

Lorundrostat for Adults With Uncontrolled and Treatment-Resistant Hypertension This randomized clinical trial compares the efficacy and safety of lorundrostat for lowering blood pressure when added to a prescribed antihypertensive regimen of 2 to 5 medications vs placebo among participants with uncontrolled hypertension, including those with treatment-resistant hypertension.

In this pivotal phase 3 RCT, lorundrostat lowered blood pressure in adults with uncontrolled or treatment-resistant #hypertension on multiple antihypertensive medications. ja.ma/3HiFclY

Endothelial PRMT7 prevents dysfunction, promotes revascularization and enhances cardiac recovery post-myocardial infarction - Experimental & Molecular Medicine Myocardial infarction (MI), commonly known as a heart attack, is a leading cause of death worldwide. Researchers are exploring ways to improve heart recovery after MI. This study focuses on a protein ...

Endothelial PRMT7 prevents dysfunction, promotes revascularization and enhances cardiac recovery post-myocardial infarction🔓
www.nature.com/articles/s12...

Pottery production, early urbanization and the Uruk phenomenon at Tell Brak in Upper Mesopotamia - Archaeological and Anthropological Sciences Tell Brak is one of the largest sites in Upper Mesopotamia, where urbanism and social complexity already emerged in the late 5th and early 4th millennia BCE. This paper combines ceramic petrography an...

Pottery production, early urbanization and the Uruk phenomenon at Tell Brak in Upper Mesopotamia🔓
link.springer.com/article/10.1...

Helicobacter pylori base-excision restriction enzyme in stomach carcinogenesis Abstract. Many recent lines of evidence from the human microbiome and other fields indicate bacterial involvement in various types of cancer. Helicobacter

Helicobacter pylori base-excision restriction enzyme in stomach carcinogenesis🔓
academic.oup.com/pnasnexus/ad...

Use of biomass-derived biochar as a sustainable material for carbon sequestration in soil: recent advancements and future perspectives - npj Materials Sustainability npj Materials Sustainability - Use of biomass-derived biochar as a sustainable material for carbon sequestration in soil: recent advancements and future perspectives

Use of biomass-derived biochar as a sustainable material for carbon sequestration in soil: recent advancements and future perspectives🔓
www.nature.com/articles/s44...

A Taste of the past: cooking ware traditions from Bronze Age to classical Thessaloniki Toumba, Central Macedonia, Northern Greece The site of Thessaloniki Toumba situated in Central Macedonia on the coastal plain of the Thermaic Gulf, in Northern Greece, holds significant archaeo…

A Taste of the past: cooking ware traditions from Bronze Age to classical Thessaloniki Toumba, Central Macedonia, Northern Greece🔓
www.sciencedirect.com/science/arti...

Characteristics of Hearing Loss in Type 2 Diabetes Mellitus: A Systematic Review and Meta‐Analysis Methods A systematic review of CINAHL, Cochrane Library, PubMed, and SCOPUS databases was conducted according to PRISMA guidelines to identify studies evaluating T2DM and hearing loss. Primary outco...

Characteristics of Hearing Loss in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis🔓
aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1002/...

Exercise Intolerance and Response to Training in Patients With Postacute Sequelae of SARS-CoV2 (Long COVID): A Scientific Statement From the American Heart Association | Circulation The postacute sequelae of SARS-CoV-2, also known as Long COVID, may affect 10% to 25% of individuals diagnosed with SARS-CoV-2. More than 100 symptoms have been reported among patients with Long COVID...

Exercise Intolerance and Response to Training in Patients With Postacute Sequelae of SARS-CoV2 (Long COVID): A Scientific Statement From the American Heart Association🔓
www.ahajournals.org/doi/10.1161/...

Paper-based flexible electronic devices: processing, integration, and applications - npj Flexible Electronics npj Flexible Electronics - Paper-based flexible electronic devices: processing, integration, and applications

Paper-based flexible electronic devices: processing, integration, and applications🔓
www.nature.com/articles/s41...

Large-scale photonic processors and their applications - npj Nanophotonics npj Nanophotonics - Large-scale photonic processors and their applications

Large-scale photonic processors and their applications🔓
www.nature.com/articles/s44...

Initiation of Pregabalin vs Gabapentin and Development of Heart Failure This cohort study assesses whether pregabalin is associated with higher incidence of heart failure compared with gabapentin in older populations with noncancer chronic pain.

Initiation of Pregabalin vs Gabapentin and Development of Heart Failure🔓
jamanetwork.com/journals/jam...

Environment and hunting territories for Late Neanderthals in central Italy: new palaeoecological data from Grotta dei Santi (Monte Argentario – Tuscany, Italy) The Italian peninsula is a key biogeographical region in southern Europe, which acted as a refugium for flora and fauna and favoured the persistence o…

Environment and hunting territories for Late Neanderthals in central Italy: new palaeoecological data from Grotta dei Santi (Monte Argentario – Tuscany, Italy)🔓
www.sciencedirect.com/science/arti...

Baseline isotopic variability in plants and animals and implications for the reconstruction of human diet in 1 st century AD Pompeii - Scientific Reports Scientific Reports - Baseline isotopic variability in plants and animals and implications for the reconstruction of human diet in 1 st century AD Pompeii

Baseline isotopic variability in plants and animals and implications for the reconstruction of human diet in 1 st century AD Pompeii🔓
www.nature.com/articles/s41...

Figure 1. Pathophysiology, Progression, and Complications of Acute Diverticulitis

#Diverticulitis, an inflammatory condition of diverticula, affects roughly 180 per 100 000 people annually in the US.

This Review summarizes current evidence and treatment of diverticulitis.

ja.ma/45y9w5i #MedSky

Figure 1. Radiographic Images of the Thoracic Spine

#Osteoporosis is a common condition among older adults that leads to increased susceptibility to fracture.

Learn more about the epidemiology, diagnosis, and treatment of osteoporosis in this review.

ja.ma/4owy2vo #MedSky

Black holes don’t just swallow light, they sing. And we just learned the tune Using a powerful mathematical tool, scientists have unveiled the intricate "ringing" of black holes, unlocking patterns missed for decades and laying the groundwork for sharper gravitational wave meas...

www.sciencedaily.com/releases/202...

📖 Validation and Epidemiologic Definition of the Novel Steatotic #Liver Disease Nomenclature in a National United States Cohort With #Cirrhosis: ow.ly/5btu50Ww7Rh

For #FossilFriday have a look at the Late Cretaceous vertebrate remains of a Transylvanian Titanosaur and an anatomical record of the remains described by Diaz et al. (2025) in JSP.
Read the full study here: buff.ly/0eDwNJI

#PaleoSky #NHM #Dinosaur #Fossils #NaturalHistory #Giant #JSP #MindBlown

Our(?) Concept of Food or, They are Eating Their Pets This article examines the idea that deep disagreements are best understood as rooted in conceptual differences rather than differences in judgments and opinions, by means of a reflection on the diffe....

Our(?) Concept of Food or, They are Eating Their Pets🔓
onlinelibrary.wiley.com/doi/10.1111/...

Poly(ADP-ribose) polymerase 1 orchestrates vascular smooth muscle cell homeostasis in arterial disease - Experimental & Molecular Medicine Vascular smooth muscle cells (VSMCs) help to control blood vessel function and can change from a contractile state to a synthetic state, which is important for healing but can also lead to diseases su...

Poly(ADP-ribose) polymerase 1 orchestrates vascular smooth muscle cell homeostasis in arterial disease🔓
www.nature.com/articles/s12...

New regional-scale Classic Maya population density estimates and settlement distribution models through airborne lidar scanning Vast tracts of tropical forest of the Yucatan Peninsula have remained largely uninhabited for the last 1000 years representing a rare opportunity to d…

New regional-scale Classic Maya population density estimates and settlement distribution models through airborne lidar scanning🔓
www.sciencedirect.com/science/arti...

Gliflozins in hypertension: basic mechanisms and clinical insights | American Journal of Physiology-Renal Physiology | American Physiological Society Sodium-glucose cotransport (SGLT) inhibitors, or gliflozins, initially developed for managing type 2 diabetes mellitus, have emerged as promising therapeutic agents for hypertension, offering both car...

Gliflozins in hypertension: basic mechanisms and clinical insights🔓
journals.physiology.org/doi/full/10....

BPS Publications Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidenc...

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases🔓
bpspubs.onlinelibrary.wiley.com/doi/full/10....

Is There a Reproducibility Crisis? On the Need for Evidence-based Approaches The ‘Sixth Report—Reproducibility and Research Integrity’ (UK House of Commons Science, Innovation and Technology Committee 2023. ‘Sixth Report—Reproducibility and Research Integrity’) (‘The Report...

Is There a Reproducibility Crisis? On the Need for Evidence-based Approaches🔓
www.tandfonline.com/doi/full/10....

New onset of type 1 and type 2 diabetes post-COVID-19 infection: a systematic review COVID-19 may primarily cause respiratory symptoms but can lead to long-term effects known as long COVID. COVID-19-induced diabetes mellitus was reported in many patients which shares characteristic...

New onset of type 1 and type 2 diabetes post-COVID-19 infection: a systematic review🔓
www.tandfonline.com/doi/full/10....

Adherence to plant-based diets and long-term changes in cardiometabolic markers: a longitudinal analysis in a population-based cohort The evidence on the association between adherence to plant-based diets and longitudinal changes in preclinical cardiometabolic markers among general p…

Adherence to plant-based diets and long-term changes in cardiometabolic markers: a longitudinal analysis in a population-based cohort🔓
www.sciencedirect.com/science/arti...

The latest TBME research features a breakthrough in early-stage cognitive screening: "A Multi-modality Fusion Model based on Dual‑task Measurement for the Automatic Detection of Early‑stage #CognitiveImpairment"

https://ieeexplore.ieee.org/document/11048422?utm_source=bluesky&utm_medium=social

What is Cardiometabolic HFpEF and How Can We Study it Preclinically? Cardiometabolic heart failure with preserved ejection fraction (HFpEF) has emerged as a distinct and dominant endotype of HFpEF. Driven by prevalent c…

What is Cardiometabolic HFpEF and How Can We Study it Preclinically?🔓
www.sciencedirect.com/science/arti...

Insights into the natural history and disease course of eosinophilic esophagitis Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease marked by eosinophilic inflammation and esophageal dysfunction, with a significant impact on morbidity, quality of life, and health...

Insights into the natural history and disease course of eosinophilic esophagitis🔓
www.annallergy.org/article/S108...

Adipokines Pathogenesis in Heart Failure Explore the role of adipokines in heart failure pathogenesis, including ANGPTL2, FGF21, and osteopontin, and their impact on prediction, diagnosis, and prognosis.

This commentary highlights the role of adipokines, like ANGPTL2, C1q/TNF-related proteins 3 and 9, Fibroblast growth factor 21, Osteopontin, and Tumor necrosis factor-alpha observed in the pathogenesis of heart failure.

#OpenAccess: tinyurl.com/28yfyxug