Nixa Sedes, MD

The role of liver sinusoidal endothelial cells in liver diseases: Key players in health and pathology Liver sinusoidal endothelial cells (LSECs) are specialised endothelial cells that orchestrate hepatic homeostasis within the liver sinusoid. Besides t…

The role of liver sinusoidal endothelial cells in liver diseases: Key players in health and pathology🔓
www.sciencedirect.com/science/arti...

Reduced Vegetation Uptake During the Extreme 2023 Drought Turns the Amazon Into a Weak Carbon Source Drought turned the biogeographic Amazon in 2023 to a weak carbon source, with a magnitude similar to the drought of 2015 but less than 2016 Seasonal development of net carbon exchange in 2023 was...

Reduced Vegetation Uptake During the Extreme 2023 Drought Turns the Amazon Into a Weak Carbon Source🔓 - Botía - 2026 - AGU Advances - Wiley Online Library agupubs.onlinelibrary.wiley.com/doi/10.1029/...

Low-Density Lipoprotein Cholesterol Lowering and Risk of Major Adverse Cardiovascular Events in Primary Prevention Trials: A Meta-Analysis Analyses of statin trials by the Cholesterol Treatment Trialists’ Collaboration (CTTC) have suggested larger relative risk reduction (RRR) for major a…

Low-Density Lipoprotein Cholesterol Lowering and Risk of Major Adverse Cardiovascular Events in Primary Prevention Trials: A Meta-Analysis🔓
www.sciencedirect.com/science/arti...

Multifunctional biosensors redefining liquid biopsy: advancing simultaneous multianalyte detection Liquid biopsy has revolutionized noninvasive disease diagnosis and monitoring by detecting circulating biomarkers such as tumor-derived DNA, miRNAs, proteins, exosomes, and circulating tumor cells in body fluids. Conventional single-analyte approaches fail to capture disease complexity, limiting diagnostic accuracy. Multifunctional biosensors enable simultaneous detection of multiple biomarkers, representing a paradigm shift in liquid biopsy. This review highlights recent advances in diverse detection strategies, including optical, electrochemical, plasmonic, and clustered regularly interspaced short palindromic repeats–based assays, alongside innovations in hybrid platforms, smart surface engineering, and nanotechnology. We also discuss integration with microfluidics, artificial intelligence, and chemometric analysis to enhance sensitivity, reduce signal interference, and improve scalability. Finally, challenges in clinical translation and standardization are highlighted, underscoring the transformative potential of multifunctional biosensors in precision medicine and early disease detection.

Online now: Multifunctional biosensors redefining liquid biopsy: advancing simultaneous multianalyte detection

Molecular evolution and diversity of the norovirus RNA-dependent RNA polymerase🔓
www.nature.com/articles/s41...

From nicotine to SARS-CoV-2 antivirals with potent in vivo efficacy and a broad anti-coronavirus spectrum🔓
www.nature.com/articles/s41...

The heart-brain axis in the context of cardiovascular disease The heart-brain axis forms an important physiological network, which is increasingly gaining recognition due to its involvement in cardiac function under steady-state conditions and pathological modifications of the heart in cardiovascular disease. ...

The heart-brain axis in the context of cardiovascular disease🔓
pmc.ncbi.nlm.nih.gov/articles/PMC...

Integrated hydrogel microneedle aptamer sensor for wearable insulin monitoring Wearable biosensors can continuously monitor disease biomarkers, therapeutic drugs and health-related analytes to provide real-time diagnostic insights. The wearable biosensor Aptalyzer integrates hydrogel microneedles and an electrochemical ...

Integrated hydrogel microneedle aptamer sensor for wearable insulin monitoring🔓
pmc.ncbi.nlm.nih.gov/articles/PMC...

Macrophage κ-OR mitigates hypoxic #PulmonaryHypertension & right #HeartDysfunction by activating an SCD1-dependent anti-inflammatory axis, providing a basis for therapeutic targeting of κ-OR in pulmonary #VascularRemodeling.

#OpenAccess: doi.org/10.1016/j.ge...

📢New publication in THEORIA (Online first): “Time dilation and rates of the passage of time” — Peter J. Riggs.

▶️DOI: 10.1387/theoria.27426

🔗https://ojs.ehu.eus/index.php/THEORIA/article/view/27426

AI-driven complex systems redefine cognitive science

AI-driven complex systems redefine cognitive science🔓
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Biography of a Levantine dolmen during the Early Bronze Age: construction, reuse and memory at Rjile (Kufr Yuba, North Jordan) The architectural and ritual biography of dolmen ST_30 in the Rjile necropolis (Kufr Yuba, Jordan) provides new chronological and cultural insights in…

Biography of a Levantine dolmen during the Early Bronze Age: construction, reuse and memory at Rjile (Kufr Yuba, North Jordan)🔓
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Etched in stone? Exploring temporality through the itineraries of ten stone inscriptions from a Roman frontier fort in Wales Time is a fundamental but underexplored concept in archaeology. The materiality of stone in particular warrants attention in exploring the ways people respond to things as they conceptualize the pa...

Full article: Etched in stone? Exploring temporality through the itineraries of ten stone inscriptions from a Roman frontier fort in Wales www.tandfonline.com/doi/full/10....

Amyloidosis in Carpal Tunnel Syndrome and 1‐Year Cardiovascular and Renal Outcomes: A Propensity Score–Matched Cohort Study🔓
www.ahajournals.org/doi/10.1161/...

Gut-Heart Axis in Myocardial Repair: Mechanisms, Cross-Organ Networks, and Therapeutic Opportunities🔓
www.ahajournals.org/doi/10.1161/...

Triptan Initiation and Cerebrovascular Events in Patients With Migraine: A Nationwide Cohort Study | Journal of the American Heart Association

Triptan Initiation and Cerebrovascular Events in Patients With Migraine: A Nationwide Cohort Study 🔓
www.ahajournals.org/doi/10.1161/...

This is figure 1, which shose psychedelics induce brain desynchronization.

A Review in Nature Medicine outlines the science behind psychedelic medicine and integrates mechanistic knowledge with clinical evidence across neuropsychiatric indications, highlighting challenges, controversies and opportunities. go.nature.com/4amcefC #medsky #Neuroskyence 🧪

Machine Learning Models Rival Some Human Translators AI translation models are now rivaling junior and medium-level human translators.

What happens when AI translation meets human expertise? See how GPT-4 stacks up against seasoned professionals.

New iMetaomics research shows soil microbes control nitrogen balance and crop gene expression after fumigation—connecting microbial shifts to nutrient turnover and plant metabolism for smarter, sustainable nutrient management.

#OpenAccess➡️ https://ow.ly/yYsy50YepH5

#SoilScience #Microbiome

Palaeoscolecids from the early Cambrian Guanshan biota, Yunnan Province, China Palaeoscolecidomorphs (Palaeoscolecida and Cricocosmiidae) are widespread early Palaeozoic worms crucial to understanding the early evolution of Ecdysozoa. They are well known from the early–middle C...

Palaeoscolecids from the early Cambrian Guanshan biota, Yunnan Province, China 🔓- Shi - 2026 - Papers in Palaeontology - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....

From resistance genes to resistance states: A transcriptomics-driven precision medicine framework for antimicrobial therapy Antimicrobial resistance (AMR) is increasingly addressed through genomic approaches that identify resistance genes and mutations. While these methods …

From resistance genes to resistance states: A transcriptomics-driven precision medicine framework for antimicrobial therapy🔓
www.sciencedirect.com/science/arti...

Timing and amplitude of hydroclimate changes during the last glacial cycle in southwestern North America The presently (semi)arid southwestern North America experienced major shifts in hydroclimate during the Quaternary characterized by oscillations betwe…

Timing and amplitude of hydroclimate changes during the last glacial cycle in southwestern North America🔓
www.sciencedirect.com/science/arti...

The heavy connection: Decline in heavy-duty tools correlates with megaherbivore disappearance in the Paleolithic Levant Early Paleolithic (ca. 2-0.2 mya) lithic assemblages are marked by the recurrent presence of diagnostic heavy-duty tool classes, namely, handaxes, cho…

The heavy connection: Decline in heavy-duty tools correlates with megaherbivore disappearance in the Paleolithic Levant🔓
www.sciencedirect.com/science/arti...

Exploring the Association Between Autoimmune and Inflammatory Diseases and Uveitis To evaluate the association between immune-mediated inflammatory diseases (IMIDs) and uveitis.Retrospective cohort and case-control study using electr…

Exploring the Association Between Autoimmune and Inflammatory Diseases and Uveitis🔓
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Cigarette Smoking Exposure and Clinical Outcomes in Graves’ Disease 🔓 academic.oup.com/jcem/article...

Dosing Biologic Drugs for Patients With Obesity: One Size Does Not Fit All Click on the article title to read more.

Dosing Biologic Drugs for Patients With Obesity: One Size Does Not Fit All 🔓 - Balevic - Arthritis & Rheumatology - Wiley Online Library acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

Electron and focused ion beam microscopy of fossilized Albertosaurus sarcophagus (Dinosauria: Theropoda) bone reveals nano to microscale features🔓
www.nature.com/articles/s41...

Myocardial Dysfunction in Primary Mitral Regurgitation This narrative review describes current guidelines for intervention in severe primary mitral regurgitation and explores an approach that incorporates additional injury assessment, novel imaging marker...

Myocardial Dysfunction in Primary Mitral Regurgitation 🔓 jamanetwork.com/journals/jam...

Beyond Eosinophils: Redefining the Spectrum of Esophageal Inflammatory Diseases Through an Immune-Centric Paradigm Traditional classification of esophageal inflammatory diseases (EIDs) relies on predominant cell infiltrates, with eosinophilic esophagitis (EoE) defi…

Beyond Eosinophils: Redefining the Spectrum of Esophageal Inflammatory Diseases Through an Immune-Centric Paradigm🔓
www.sciencedirect.com/science/arti...