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•Reviews how mitochondrial protein import maintains cellular and organelle homeostasis.
•Summarizes the main stress response pathways (ISR, UPRam, UPRmt, mitophagy) triggered by import dysfunction.
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This review integrates evidence from preclinical and clinical studies to explain how tryptophan catabolism interacts with microbial activity and steroid regulation.
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Effects of exercise on the intercellular communications, inflammation, and gut microbiome.

Exercise attenuates the hallmarks of aging: Novel perspectives
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When cancer adapts to new organs The three-dimensional arrangement of DNA within a cell might influence the ability of a tumor to metastasize to specific locations.

The 3D arrangement of DNA within a cell might influence the ability of a tumour to metastasise to specific locations.
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Cinnamaldehyde suppresses ovarian cancer progression by activating ROS-mediated apoptosis and mitophagy
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Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender Huang et al. show that excessive vigorous exercise causes cognitive impairment. During this process, muscle lactate accumulation facilitates the secretion of otMDVs through ATF5 lactylation. PAF and m...

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender: Cell Metabolism www.cell.com/cell-metabol...

The fun leaving your body the moment you're done with the science and it's time to get it published

Dual photoreception via rho and opn4al2 drives light-dependent color plasticity in Plectropomus leopardus Body coloration in fish is crucial for ecological adaptation and commercial value, regulated by opsin-based photoreception in response to ambient ligh…

Fish skin has independent "visual" system

Red light → activates Rho → melanin suppression→skin lightening
Blue light → activates Opn4al2 → melanin synthesis → skin darkening

Melanocyte opsins function as light-triggered pigment switches for eye-independent color adaptation

Daily steps and sleep in adults: A systematic review and meta-analysis Sleep problems constitute a global public health challenge, imposing adverse health consequences and substantial economic costs. Although physical act…

• Higher daily steps link to better #sleep quality, shorter sleep duration, and reduced daytime dysfunction
• Step-increasing interventions improve sleep duration and reduce sleep disturbances
• No consistent step-sleep relationships were found for sleep latency or sleep efficiency

Association between hospital arrival time/day and mortality in pediatric patients with severe trauma: a nationwide retrospective observational study in Japan This study aimed to evaluate the association between hospital arrival time/day and mortality in pediatric patients with severe trauma.This retrospecti…

• This study found that nighttime hospital arrival was associated with higher in-hospital mortality in pediatric patients with severe trauma.
• Establishing medical systems that deliver continuous, high-quality care is essential for reducing mortality in this patient population.

Circadian clocks and adaptive immune function: from mechanisms to therapeutic applications
www.frontiersin.org/journals/imm...

Near-infrared light improves postoperative cognitive dysfunction by alleviating Lcn2-dependent ferroptosis induced neuronal injury Iron overload and oxidative stress significantly contribute to the pathophysiology of postoperative cognitive dysfunction (POCD). Our previous finding…

•NIR improves cognitive function in aged POCD mice by reducing hippocampal and neuronal ferroptosis.
•Lcn2 regulates ferroptosis and is a promising target for alleviating POCD.
•NIR suppresses Lcn2 to mitigate hippocampal neuronal ferroptosis in POCD.

Cancer, deuterium, and gut microbes: A novel perspective
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Real-World Data Confirm That the Integration of Deuterium Depletion into Conventional Cancer Therapy Multiplies the Survival Probability of Patients Background: Over thirty years of basic research has demonstrated that the deuterium-to-hydrogen ratio plays a pivotal role in regulating metabolism and cell growth via a sub-molecular regulatory system that orchestrates the intricate complexity of ...

The real-world data analysis suggests that integrating deuterium depletion via DDW into standard cancer treatments could multiply survival probability by a factor of 4–5 and lower cancer-specific mortality rates by approximately 75–80%."

Immune Dysregulation and Neuroinflammation in Bipolar Disorder: Pathophysiological Insights and Therapeutic Perspectives
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This study offers a comprehensive overview of current developments in EV research for the main autoimmune conditions, including inflammatory bowel disease, systemic lupus erythematosus, and rheumatoid arthritis.
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Vitamin C combined with anti-PD-1 antibody alleviates peripheral lymphopenia and enhances CD4+ T-cell antiviral immunity during BVDV infection Bovine viral diarrhea virus (BVDV)-induced lymphopenia is associated with immune dysfunction. Vitamin C (VC) improves immune response by increasing pe…

•Vitamin C combined with PD-1 blockade alleviates lymphopenia during BVDV infection
•Vitamin C downregulated PD-1 expression in CD4+ T-cell of BVDV-infected mice
•Vitamin C enhanced CD4+ T-cell antiviral immunity during NCP BVDV infection

A mugshot registration photograph from Auschwitz. A woman wearing a striped uniform photographed in three positions (profile and front with a bare head and a photo with a slightly turned head with a headscarf on). The prisoner number is visible on a marking board on the left.

30 November 1898 | A Polish woman, Łucja Smerańska, was born in Stary Sącz. A teacher.

In #Auschwitz from 29 January 1943.
No. 32442
She perished in the camp on 12 March 1943.
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Women at Auschwitz

Lesson: https://lekcja.auschwitz.org/2022_kobiety_en/
Podcast: https://youtu.be/ijTxtbNlJO8

The impact of gut-liver-derived mediators on the organ crosstalk with brain, heart, and kidney: a systematic review
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In this study, we demonstrated that imeglimin alters peripheral clock gene expression in healthy mice under both acute bolus administration and chronic mixed-feeding conditions.
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https://www.sciencedirect.com/science/article/pii/S016503272502227X

• Unhealthy #sleep pattern alone: 75% higher risk of #schizophrenia (HR=1.75)
• High genetic risk (PRS) alone: 268% higher risk (HR=3.68)
• Combination of unhealthy sleep and high genetic risk: 480% higher risk (HR=5.80) compared to those with a healthy sleep pattern and low genetic risk.

The PER2:BRCA1:POU2F1(OCT-1) Ternary Complex Represents a Multi-Component Scaffold Model for Circadian Gene Regulation

Disruption of the ternary complex by BRCA1 mutations or #circadian misalignment may mechanistically link #cancer risk to circadian disruption.
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TCA cycle enzyme activity of citrate synthase, succinate, and malate dehydrogenases as a function of LMF and their non-linear fittings.

Mitochondrial respiration as a function of applied LMF.

Low Magnetic Fields Stimulate Cardiac Mitochondrial Bioenergetics with a Bell-Shaped Response: Possibly Via a Radical Pair Mechanism Low magnetic fields (LMFs) of less than 1 ×10-3Tesla (T) affect numerous biological processes, including plant growth and bird migration. At a cellula…

Narrow range of LMF can enhance mitochondrial bioenergetics and decrease mROS, through the radical pair mechanism of magnetoreception. These basic findings in isolated cardiac mitochondria may encourage future studies that apply quantum mechanics to explore the mitochondrial electron transfer system

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by the synergy of innate immune activation and metabolic stress. This process is regulated by mTORC2 and involves persis...

#NoTimeToDie! Welcome mitoxyperiosis! ⁦‪Kanneganti, Wang‬⁩ &co show ⁦‪@cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!

Key Findings on Depression & Metabolic Dysfunction (25 Studies):

↑ Fasting glucose in depression
Dyslipidemia trends:
↑ LDL
↓ HDL
Insulin resistance linked to:
• Anhedonia severity
• Sleep disturbances
• Suicidal ideation
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Caloric Restriction Alleviates Anxiety-like Behaviors by Mitigating Neuroinflammation and Insulin Signaling Dysregulation in a High-Fat Diet-induced Obesity Mouse Model Caloric restriction (CR) is reported to promote longevity and improve metabolism in different species, such as rodents and flies. However, limited stu…

Data indicate that CR even without a change in dietary composition could attenuate HFD-induced anxiety symptoms by modulating the gut microbiota, suppressing neuroinflammation, and regulating the brain insulin signaling pathway in adult male obese mice.
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The dietary intervention influenced positively the metabolic, psychological, and circadian rhythm marker profile, highlighting potential interconnections between metabolism, circadian gene expression, and mental well-being.
www.frontiersin.org/journals/nut...