π¬ LTSV40 disrupts cell cycle regulation!
β
Induces conformational changes in pRb, blocking E2F access.
β
LXCXE motif & disordered regions are key to interference.
β
A generalized mechanism for pRb inactivation might apply to other viral oncoproteins.
23.05.2025 03:06 β π 0 π 0 π¬ 0 π 0
Frontiers | Structural and dynamical characterization of pRb, LTSV40 and the pRb-LTSV40 complex suggests a common mechanism for pRb inactivation
We have published a new article in Frontiers in Chemical Biology! π
In collaboration with Gustavo Pierdominici-Sottile
Nicolas Palopoli and Juliana Palma, we explored the interaction between the retinoblastoma protein and the simian virus 40 large T antigen.
www.frontiersin.org/journals/che...
23.05.2025 03:05 β π 1 π 0 π¬ 1 π 0
Latin American journals are open-access pioneers. Now, they need an audience
SciElo, other platforms work to help journals reach readers around the world
Latin America is a leader in nonprofit open-access, with pioneering platforms like Scielo and Redalyc. But it still struggles to have their journals valued at home, as researchersβ perfomances often depend on them publishing on mainstream commercial journals.
www.science.org/content/arti...
06.12.2024 12:56 β π 42 π 11 π¬ 0 π 3
Intro slide with cute drawings in the background and a text box saying "The cute side of proteins. Behind every scientific discovery, lies a story. Often this story is of a scientist and their passion and awe for natureβs design."
A woman is making the shape of a heart with her hands. Next to her is a model of molecular structure of a protein overlaid on a drawing of the human heart. A text box below says: "Maria Costanzo from EMBL Barcelona is fascinated by the YAP protein β its interesting abilities and its heart shape.". Protein reference: Alphafold P46938.
A man is blowing soap bubbles. Next to him is a circular shape containing several protein structures, which have an empty middle and concentrically arranged petal-like parts. The text box above says: "Veijo Salo from EMBL Heidelberg describes his favourite protein, seipin, as a molecular bubble blower, tightly holding fat bubbles inside a cell." Protein reference: PDBe SDS5.
A woman is petting a complex of molecules that looks like a poodle. The text below says: "Sarah Gharbi from EMBL Grenoble describes this protein complex as a poodle: it has a head (E.coli elongation factor protein), a muzzle (tRNA), a body (SidH), and even a flexible tail, like a dog!". Protein reference: PDBe 8QFS.
Science is full of wonder, creativity, and unexpected stories!
π In this special series, EMBL scientists share their passion about proteins in stories full of curiosity and imagination.
π Join us in uncovering natureβs hidden structures!
Complete series here: www.embl.org/news/tag/cut...
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10.04.2025 08:27 β π 26 π 5 π¬ 1 π 3
π¨ Big News from #3DSIG at #ISMB2025!
Weβre thrilled to announce our incredible Keynote Speakers for this yearβs edition! π§ β¨
@ffrancafrat.bsky.social @adrianmulholla1.bsky.social @diegulise.bsky.social
Remember to submit your abstractπhttps://easychair.org/conferences/?conf=ismbeccb2025
#3DSIG #ISCB
10.04.2025 19:25 β π 8 π 3 π¬ 0 π 1
βοΈIt's the final day to submit your abstract for
#SCS2025
𧬠Join in person or online β a great chance for early-career researchers to present and network in bioinformatics
β
A 250-word abstract is all you need
ποΈ Deadline: April 17
π easychair.org/account2/sig...
@iscb.bsky.social @ebi.embl.org
16.04.2025 09:55 β π 6 π 2 π¬ 0 π 0
π The 14th ISCB #Wikipedia Competition is here!
Students and postdocs are invited to create or improve Wiki articles on #ComputationalBiology and #ISCB core topics.
π Prizes include cash awards and a 1-year ISCB membership!
π
Deadline: May 2, 2025
π t.ly/hIJQy
10.12.2024 15:10 β π 4 π 3 π¬ 0 π 0