Philipp Kuhnke

This is work together with @numole.bsky.social, @jvoeller.bsky.social, @vincentcheung.bsky.social, Konstantin Weise, Markus Kiefer and @gesahartwigsen.bsky.social @copla.bsky.social @unileipzig.bsky.social @mpicbs.bsky.social.

(PDF) Left inferior parietal lobe and auditory cortex jointly contribute to sound knowledge retrieval PDF | Background Conceptual knowledge is central to human cognition. Neuroimaging studies suggest that conceptual processing relies on the joint... | Find, read and cite all the research you need on R...

I’m extremely excited that this work of 3 years is finally published in @braistimjournal.bsky.social. Using condition-and-perturb TMS with e-field-based optimized targeting and dosing, we provide causal evidence for hybrid theories of semantic cognition: www.researchgate.net/publication/...

The ‘reading’ brain: Meta-analytic insight into functional activation during reading in adults Literacy provides the key to social contacts, education, and employment, and significantly influences well-being and mental health. Summarizing 163 st…

New meta-analysis on reading in the brain by @sabrinaturker.bsky.social, Beatrice Fumagalli, @gesahartwigsen.bsky.social and myself. We looked for consistent activations across multiple levels - from letters to words to sentences to and text reading. www.sciencedirect.com/science/arti...

Causal Contributions of Left Inferior and Medial Frontal Cortex to Semantic and Executive Control Semantic control guides the targeted and context-based retrieval from semantic memory. The overlap with and dissociation from domain-general executive control in the frontal lobe remains contentious. ...

🧠 How do semantic and executive control dissociate in the frontal lobe? Applying TMS to IFG and pre-SMA, we find:
⚡ Specialization
▸ IFG = semantic (and executive) control
▸ pre-SMA = executive functions
🔄 Compensation between both regions during single-site disruption!
Read more: shorturl.at/UVtRk

Comparison of whole-brain task-modulated functional connectivity methods for fMRI task connectomics - Communications Biology Large-scale neural mass simulations revealed best task-modulated functional connectivity methods for different fMRI designs and fundamental limitations for detecting rapid modulations of neural synchr...

I found it quite impressive that a recent simulation study by Masharipov et al. (2024) could show that deconvolution in PPI analyses of task-modulated functional connectivity massively increases sensitivity and ability to estimate directionality (vs. without deconvolution): doi.org/10.1038/s420...

Thrilled to share our latest research with PhD student @zijianfeng.bsky.social and Postdoc @drsandramartin.bsky.social! We investigated TMS-induced heart–brain coupling (HBC) as a potential biomarker for personalized stimulation targets in the left DLPFC: doi.org/10.1101/2025...

Postdoc @drsandramartin.bsky.social presented her research on aging effects on predictive processing in language at the Dallas Aging and Cognition Conference this week. Results show that as we age, we increasingly rely on our internal predictions, possibly as compensation for executive decline. 1/2

New insights into the mechanisms of language recovery after stroke A new study shows how the brain reorganises itself in the first few months after a stroke to improve the ability to speak again. The findings will help researchers understand how functional networks w...

New press release by @unileipzig.bsky.social about our BRAIN paper on connectivity changes during post-stroke aphasia recovery: www.uni-leipzig.de/en/newsdetai...

Excited to share our latest preprint on the retest reliability of measuring 'bilateral' hemispheric language dominance using functional neuroimaging! 🔎🧠🔍 Discover how our findings inform the challenging classification of 'small' asymmetries in brain activation: osf.io/ry4sf_v1

Cool new work by @nicohinrichs.bsky.social looking at the semantics-pragmatics continuum from both linguistic and neuroscientific angles:

🚀 Preprint alert! New work by @nicohinrichs.bsky.social, a recent member of our lab, explores multimodal dialogue annotation for neurophysiological mapping of communication—plus insights on speech acts, implicatures & turn-taking: doi.org/10.31234/osf... #Neuropragmatics #CognitiveLinguistics

More from our postdocs! This week @drsandramartin.bsky.social gave a presentation at @mpicbs.bsky.social, charting a new way forward to understand language processing in the aging brain 🍁

NYAS Publications The left temporo-parietal cortex is critical for phonological decoding during reading and appears hypoactive in dyslexia. Here, we combined facilitatory neurostimulation to this brain region with fun...

Finally published! 🥳 New TMS-fMRI study led by @sabrinaturker.bsky.social shows that temporoparietal stimulation can alleviate dyslexia. This was associated with changes in effective connectivity between left IFG and the visual word form area: doi.org/10.1111/nyas...

Lab meeting time! Last week, @robingerrits.bsky.social, who joined the lab at the end of last year, told us about his future projects, connecting his main research interest, brain laterality, to brain stimulation - fascinating combination! 🧩

Happy 30th birthday year to SPM!! 🎈🍰

To get the party started, we are delighted to announce SPM 25.01, a major new version of the open-source neuroimaging software.

Read the preprint to discover what's new arxiv.org/pdf/2501.12081 and download SPM for free from Github github.com/spm/spm/rele...

informal announcement: we'll be doing a *cluster* hire of faculty in theoretical/computational neuroscience in the coming year(s). a senior/mid-career person could be selected to bring in 2-3 more ppl of their choosing (subject to committee approval), or we could otherwise hire together a group 1/

Thanks a lot, Rocco! Looking forward to hearing what you think.

Thank you, Ole! Another awesome collab with you and @brainnetleipzig.bsky.social

YouTube video by Organization for Human Brain Mapping OHBM 2024 | Oral Session | Philipp Kuhnke | Left inferior parietal lobe and auditory cortex joint…

I also gave a talk on this study at @ohbmofficial.bsky.social 2024 in Seoul. Check it out: youtu.be/4HkHnrhN1uk?...

Meta-analytic evidence for a novel hierarchical model of conceptual processing Conceptual knowledge plays a pivotal role in human cognition. Grounded cognition theories propose that concepts consist of perceptual-motor features r…

Our findings support “hybrid theories” of conceptual processing, which propose that task-dependent functional interactions between modality-specific and multimodal regions are crucial, such as our hierarchical convergence model proposed here: www.sciencedirect.com/science/arti...

These results indicate that the joint contribution of multimodal IPL and auditory cortex is causally relevant for sound knowledge retrieval: The functional relevance of left IPL depends on the integrity of the auditory cortex as single perturbation of either region did not disrupt performance.

The individual impairment of sound judgments was best explained by the electric field in the auditory cortex.

We found that combined stimulation of auditory cortex and multimodal IPL selectively impaired sound judgments, but not action judgments, on low sound–low action words. Unifocal TMS over auditory cortex or IPL alone did not disrupt behavior, suggesting adaptive compensatory plasticity.

For the first time in a TMS study on higher cognition, we optimized TMS targeting and dosing using a priori computational electric field simulations (see doi.org/10.1162/imag...).

To tackle this issue, we combined offline TMS over modality-specific cortex (somatomotor, auditory, or sham) with online TMS over multimodal cortex (IPL, or sham) while 24 participants performed action and sound knowledge tasks on written words.

Task-Dependent Functional and Effective Connectivity during Conceptual Processing Abstract. Conceptual knowledge is central to cognition. Previous neuroimaging research indicates that conceptual processing involves both modality-specific

Neuroimaging studies suggest that conceptual processing involves functional coupling between multimodal and modality-specific areas (doi.org/10.1093/cerc...). However, it remains unclear whether these interactions are causally relevant for behavior.

This is work together with @jvoeller.bsky.social, @vincentcheung.bsky.social, @numole.bsky.social, Konstantin Weise, Markus Kiefer and @gesahartwigsen.bsky.social at @unileipzig.bsky.social and @copla.bsky.social @mpicbs.bsky.social.

🚨 New preprint!! Using condition-and-perturb TMS, we show that functional interaction between multimodal and modality-specific cortices is causally relevant for conceptual knowledge retrieval: ssrn.com/abstract=510...

Thanks, Jamie! We will take it as a compliment ;)

Our lab is now also on BlueSky!