Fluorochem Ltd

Selection of structures and product details of GPCR modulators available in the Fluorochem catalogue.

GPCRs are highly druggable yet complex. Fluorochem’s small molecules, including agonists & antagonists, help tune signalling processes, study ligand-receptor interactions & explore disease pathways. Perfect tools for #Biochem #DrugDiscovery #MedChem #Protein #Signalling research!

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...

PFAS (“forever chemicals”) are everywhere — water, soil, even our blood. A new study finds they can build up in gut bacteria without harming them. In mice, these PFAS-loaded microbes were later excreted, opening the door to probiotic-based ways to remove PFAS.

#PFAS #PublicHealth #Microbiome

Phase Transfer Catalysts 🧪

Transporting reaction components between phases, our phase-transfer catalysts efficiently accelerate synthetic and industrial processes while improving solvent economy.

#ChemSky #LabLife #OrgChem #OrganicChemistry #SustainableChemistry

fluorochem.co.uk/product-cate...

Bottom‐Up Regulation of Perovskite Growth and Energetics via Oligoether Functionalized Self‐Assembling Molecules for High‐Performance Solar Cells Oligoether chain was incorporated to construct self-assembling molecules, which can not only enable good coverage and optimized buried interface properties but also assist high-quality and ordered pe...

Researchers have achieved stable devices with 25.5% energy efficiency when combining self-assembling molecules (EPA and MEPA) with Nickel oxide PSCs. Continuous improvement will make solar energy an economically viable answer to energy demand.🧪
#SolarEnergy #GreenChem #Renewable #Sustainability

Find transition-metal complexes to catalyse molecular remodelling. Fluorochem’s selection covers heavy-hitting stalwarts like Grubbs, precious metal catalysts including palladium and gold and powerful complexes using earth abundant metals.🧪
#ChemSky #Catalysts #Metal #Catalysis #AcademicSky

Speak to Fluorochem at the 28th International Symposium: Synthesis in Organic Chemistry.
Find out how we can support your #synthesis or #medchem with our extensive range of building blocks, synthesis reagents, #NMR solvents or #photochemistry.
#AcademicSky #Conference #ChemSky #orgchem

Organocatalysts

Offering greener methods, while still producing excellent chemical results including highly selective asymmetric catalysis, Fluorochem’s organocatalysts promote countless chemical reactions.

fluorochem.co.uk/product-cate...

#ChemSky #Biosky #catalysts #organocatalyst 🧪

Controlled delivery of therapeutic molecules is an ongoing challenge of targeted medicine. This Rotaxane device can release a payload in response to force or an absence of water.
This has been tested with the chemotherapy drug gemcitabine and the biliary antispasmodic drug Hymecromone. 🧪
#ChemSky

A table of orange chemistry themed merchandise including brochures about small molecule inhibitors and squishy conical flasks. The back ground is 2 banners with the Fluorochem logo and info graphics about our service

Come and speak to us today if you're at the Chemistry symposium @ucl.ac.uk and find out how Fluorochem can support your research far beyond fluorinated compounds

#ChemSky #ucl #AcademicSky #chemistry #research 🧪

Activatable Fluorescence/Photoacoustic Macromolecular Probe for Imaging of Tumor‐Associated Natural Killer Cells An activatable near-infrared fluorescence (NIRF)/photoacoustic (PA) macromolecular probe is developed based on the optimized fluorophore scaffold with a long absorption maximum and high PA brightness...

New in chemistry, imaging and cancer

The new dye BhCyNK is designed to activate only in the presence of a specific enzyme found in tumours rich in natural killer cells. The dye produces a strong signal, helping researchers track these immune cells live, inside the body.

🧪 #Cancer #imaging

Protected amino acids - these protected forms ensure controlled stepwise synthesis, for application in solid-phase peptide synthesis (SPPS) or solution-phase methods.

Premium amino acids provide the consistency and performance your science demands.

#aminoacids #peptidesynthesis #ChemSky 🧪

Solid‐Phase Parallel Synthesis of Photocleavable Bifunctional Molecules Enables Efficient Phenotypic Protein Degrader Discovery An integrated platform enables efficient parallel solid-phase synthesis of diverse, photocleavable CRBN-focused degrader libraries. Direct-to-biology (D2B) phenotypic screening, incorporating mechani...

This study presents an integrated platform for phenotypic protein degrader discovery (PPDD)—a method particularly useful for targeting proteins that lack detailed structural or ligand-binding information.

#ChemSky #ScienceSky #AcademicSky #BioSky 🧪
onlinelibrary.wiley.com/doi/abs/10.1...

Peptide synthesis and amide bond formation are essential techniques in chemical biology.

Coupling reagents like COMU, HBTU, and HATU high efficiency, low racemization, and broad substrate compatibility make them go-to tools in both academic and industrial labs.

🧪 #ChemSky #Peptide #Biochem

Overall Survival with Inavolisib in PIK3CA-Mutated Advanced Breast Cancer | NEJM In the phase 3, double-blind, randomized INAVO120 trial, treatment with inavolisib plus palbociclib–fulvestrant led to a significant progression-free survival benefit, as compared with placebo plus...

A study funded by Roche trialled a novel triple therapy for breast cancer patients with PIK3CA –mutated HR+, HER2- breast cancer and demonstrated positive outcomes for the patients quality of life, with a few side effects which will need to be monitored.
#ScienceNews #Cancer #MedSky #Pharma 🧪

Peptides have wide applications in modern medicine and drug discovery, diagnostics and biological research. They are versatile enough to function as selective therapeutics, biomarkers and high-specificity probes in biological assays. 🧪

#ChemSky #BioSky #Peptides #Research #Benchwork

Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody‐Dependent Cytotoxicity This study presents novel macrocyclic peptides with low nanomolar affinity for CD59, an immunomodulatory cell surface receptor associated with human disease. Crystallographic and structure-activity r....

Interesting to read about macrocyclic peptides being utilised to find solutions for challenging disease-associated targets.
🧪
CD59 is associated with #cancer, #multiplesclerosis and other neurological disorders, auto-immune diseases (E.g PNH) and #viral infections.

#AcademicSky #ChemSky #MedSky

Generalizing arene C–H alkylations by radical–radical cross-coupling - Nature Using the concept of dynamic orbital selection distinct organic radical species can be differentiated, enabling direct coupling of aromatics with alcohols or carboxylic acids.

Photocatalytic approaches are widening the possibilities of synthetic chemistry. In the paper below aryl C-H bonds are directly alkylated with alcohol & carboxylate starting materials, using an iridium photocatalyst (F551860) to create active radical species. 🧪

Contact us for a quote!
#Chemsky

Continuing with our sponsor appreciation, we would like to thank Fluorochem, Lumicks and Oxford nanopore for their support!!
Remember to register now!! @fluorochemltd.bsky.social @lumicks.bsky.social @nanoporetech.com

Organoboron Building Blocks 🧪

Widely used as cross-coupling partners to rapidly assemble more complex molecules, boronic acids and their derivatives have been reliable features of medicinal chemistry, materials science and general synthesis for decades.

#ChemSky #ScienceSky #SyntheticChem #Pharma

Ethanol is present in alcoholic beverages of all kinds enjoyed by humans and, it transpires, wild chimpanzees (Pan troglodytes verus)! They've been reported to eat and share fermented African Breadfruit (Treculia africana).

Cheers! 🧪

www.cell.com/current-biol...

#AcademicSky #BioSky #ZooSky

Chiral building blocks can conveniently introduce stereocentres, giving precise structure to your molecules. Fluorochem have a range of these optically active molecules for producing compounds with selective biological activity. 🧪

#ChemSky #DrugDiscovery #Pharma #ChemicalBiology

Delighted to be attending the 11th RSC/SCI Symposium on Kinase Inhibitor Design in the beautiful city of Edinburgh on behalf of Fluorochem Ltd

Looking forward to hearing about the latest kinase related therapy development from researchers over the next 2 days.🧪

#Kinase2025
#ChemSky
#MedSky

Reflecting the increasing interest in the therapeutic value of modulating serotonergic and dopaminergic pathways, Fluorochem stock a selection of building blocks that can be used in the creation of molecules that interact with CNS receptors like D2 and 5-HT2. 🧪

#ChemSky #ChemicalBiology #Pharma

🧪 The RSC Organic Division Ireland meetings yesterday featured #macrocycles, #fluorescence, improving efficiency in chemistry and moving towards #sustainable chemical synthesis, combining optimism, innovation and an acknowledgement of the significant challenges faced.

#Chemsky #SciComm

A fantastic day of #organicchemistry 🧪 at Queen's University Belfast yesterday

#Chemsky #SciComm

Choose the right payload from Fluorochem’s range of advanced payloads to tailor your ADC design 🧪

CAS: 474645-27-7 MMAE
CAS: 171335-80-1 Exatacan
CAS: 441045-17-6 Eribulin mesylate

Our team of experts are here to help with custom synthesis!
#MedSky #BioSky #ADC #ChemSky #Pharma

Bank Holiday Alert

1st of May is the national holiday In Germany, our warehouse will reopen 2nd May 🚚

5th of May is the UK bank holiday, our warehouse will reopen 6th May 🚚

We always work to ensure these closures have a minimal impact on your delivery times.🧪

Cartoon of a scientist dressed in full PPE in a scene with a larger than life test tube rack behind them, and they're holding a test tube as big as the over a large drum barrel

Custom Synthesis Capabilities:

Small Molecules
Protein Degraders
Oligonucleotides
Peptides
Antibodies

Our deep expertise in chemical and life sciences doesn’t just shape our catalogue - it powers our ability to deliver truly customised solutions 🧪

#Medsky #antibodies #peptides #ChemSky

Scientist observing a well illuminated reaction flask containing radicals, charges and reactive chemicals.

Photoinitiators break apart when exposed to light, a process known as photodissociation. This reaction generates reactive species, such as radicals, cations, or anions, which initiate chemical reactions.🧪
Browse our catalogue for our photoinitators today!
#ChemSky #Academicsky #Photochemistry

Pharmaceutical pollution influences river-to-sea migration in Atlantic salmon (Salmo salar) Despite the growing threat of pharmaceutical pollution, we lack an understanding of whether and how such pollutants influence animal behavior in the wild. Using laboratory- and field-based experiments...

Clobazam has been found in the brain of Atlantic salmon and is changing their migratory and shoaling behaviour.
This highlights how important it is to clean up our waterways, as pharmaceutical agents become pollutants once washed into ecosystems. 🧪
#Pollution #Environment #Biosky #Chemsky