Fluorochem Ltd

We’re proud to highlight the pioneering research and manufacturing organisations we collaborate with, all working at the forefront of chemistry.

On our Insights page, you’ll learn how their products integrate seamlessly into your research🧪
#ScienceSky #Collaboration #ChemSky #LifeSciences

VHL ligands engage the VHL E3 ligase, a highly validated recruiter in PROTAC design, offering robust degradation profiles. Their structural diversity supports fine-tuning of ternary complex stability and pharmacological properties.

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🧪 #TargetedProteinDegradation

Targeted Protein Degradation

Fluorochem is here to support you as you build PROTACs or other heterobifunctional molecules with an excellent range of target-binding ligands, linkers and E3 ubiquitin ligase ligands.

🧪 #ChemicalBiology #LifeSciences #TPD

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Cereblon (CRBN) ligands the most extensively used ligase recruiters in targeted protein degradation. The CRL4 CRBN E3 ligase complex is recruited to tag proteins for ubiquitination & degradation. 🧪
#TargetedMedicine #MedicinalChemistry #ProteinDegradation #PharmaResearch #TranslationalResearch #TPD

Scalable metasurface-enhanced supercool cement Reengineered cement enables scalable radiative cooling for energy-efficient, low-carbon construction.

Cool cement is helping to keep surfaces cooler. It’s both strong and durable, meaning it can be incorporated into conventional concrete help cities moderate extreme summer temperatures.
#ClimateChange #SustainableConstruction #MaterialsScience #Chemistry 🧪

Tertrazines are ideal for pre-targeted imaging, drug delivery, and bioorthogonal chemistry. browse our range of click chemistry reagents and much much more on our site!

#Chemistry #ClickChemistry #Imaging #MolecularBiology #MedChem
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There's till time to talk to our rep in Cambridge and find out how Fluorochem can support your ADC and PROTAC synthesis, library development or custom projects!🧪

#CamMedChem25 #ADC #PROTAC #Pharma #ChemSky #BioSky #AcademicSky

Another medicinal chemistry symposium this week! Drop by to hear the latest developments at Fluorochem and new ranges in chemical building blocks, biological reagents and complex medicinal agents like ADCs OR heterobifunctional protein degraders!

#CamMedChem25
#ADCs
#ChemSky
#AcademicSky
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Click chemistry is ideal for fast, selective and modular reactions that simplify complex molecule assembly. In biological systems, copper free reagents are ideal - find them on our site!🧪

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#ChemSky #BioSky #Biochem #ClickChem #ClickReactions #MolecularBio #MedChem

How did click reactions become common practise in synthesis?
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#ClickChem #Chemistry #Biochemistry #ChemSky #clickreactions #Syntheticchem

Find everything for chemical synthesis, delivered fast, with uncompromising quality 🚚

Click chemistry simplifies complex molecule assembly with fast, selective and modular reactions. Find click reagents & more on our site!🧪
fluorochem.co.uk/product-cate...
#ChemSky #Biochem #Synthesis #Clickchem

Come and speak to us about all things #peptides #smallmolecules and #medicinalchemistry at the EFMC-ASMC x International Symposium on advances in synthetic and medicinal chemistry.

#medchem #ASMC #EFMCASMC2025 #EFMC

Click chemistry has become a go-to strategy for fast, selective and modular reactions that simplify complex molecule assembly. 🧩

Find everything you need to assemble your molecules with Fluorochem’s high quality click reagents!🧪

#ChemSky #ClickChem #Synthesis

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Kinases contribute to regulation of cellular signalling and drive many diseases when dysregulated. Small molecule kinase inhibitors allow precise control over these enzymes, enabling pathway dissection, biomarker discovery and therapeutic targeting.🧪
#Kinase #MedChem
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Ion channels control the flow of ions across membranes, governing everything from nerve impulses to cardiac rhythms. With small molecule activators and inhibitors, researchers can modulate channel activity with precision. 🧪
#ChemSky #BioSky #MedChem #IonChannel
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Proteases are involved in processes like immunity, cancer progression, and viral replication. Small molecule protease inhibitors help control these enzymes with high specificity, useful in both research and therapeutic applications. 🧪
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#SMI #protease #ChemSky #cancer

Simple device can produce water, oxygen and fuel from lunar soil Using samples collected by the Chinese Chang’e 5 mission, researchers have discovered a new way to release water from lunar regolith and process the carbon dioxide breathed out by astronauts

Lunar soil is revealing unexpected potential. A team led by Lu Wang has developed a solar-powered photothermal reactor that simultaneously extracts water from regolith and converts exhaled CO₂ into oxygen, hydrogen, and carbon monoxide, with ilmenite as a catalyst. 🧪
#Chemsky #AstroSky #Sciencenews

Selection of structures and product details of GPCR modulators available in the Fluorochem catalogue.

GPCRs are highly druggable yet complex. Fluorochem’s small molecules, including agonists & antagonists, help tune signalling processes, study ligand-receptor interactions & explore disease pathways. Perfect tools for #Biochem #DrugDiscovery #MedChem #Protein #Signalling research!

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...

PFAS (“forever chemicals”) are everywhere — water, soil, even our blood. A new study finds they can build up in gut bacteria without harming them. In mice, these PFAS-loaded microbes were later excreted, opening the door to probiotic-based ways to remove PFAS.

#PFAS #PublicHealth #Microbiome

Phase Transfer Catalysts 🧪

Transporting reaction components between phases, our phase-transfer catalysts efficiently accelerate synthetic and industrial processes while improving solvent economy.

#ChemSky #LabLife #OrgChem #OrganicChemistry #SustainableChemistry

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Bottom‐Up Regulation of Perovskite Growth and Energetics via Oligoether Functionalized Self‐Assembling Molecules for High‐Performance Solar Cells Oligoether chain was incorporated to construct self-assembling molecules, which can not only enable good coverage and optimized buried interface properties but also assist high-quality and ordered pe...

Researchers have achieved stable devices with 25.5% energy efficiency when combining self-assembling molecules (EPA and MEPA) with Nickel oxide PSCs. Continuous improvement will make solar energy an economically viable answer to energy demand.🧪
#SolarEnergy #GreenChem #Renewable #Sustainability

Find transition-metal complexes to catalyse molecular remodelling. Fluorochem’s selection covers heavy-hitting stalwarts like Grubbs, precious metal catalysts including palladium and gold and powerful complexes using earth abundant metals.🧪
#ChemSky #Catalysts #Metal #Catalysis #AcademicSky

Speak to Fluorochem at the 28th International Symposium: Synthesis in Organic Chemistry.
Find out how we can support your #synthesis or #medchem with our extensive range of building blocks, synthesis reagents, #NMR solvents or #photochemistry.
#AcademicSky #Conference #ChemSky #orgchem

Organocatalysts

Offering greener methods, while still producing excellent chemical results including highly selective asymmetric catalysis, Fluorochem’s organocatalysts promote countless chemical reactions.

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#ChemSky #Biosky #catalysts #organocatalyst 🧪

Controlled delivery of therapeutic molecules is an ongoing challenge of targeted medicine. This Rotaxane device can release a payload in response to force or an absence of water.
This has been tested with the chemotherapy drug gemcitabine and the biliary antispasmodic drug Hymecromone. 🧪
#ChemSky

A table of orange chemistry themed merchandise including brochures about small molecule inhibitors and squishy conical flasks. The back ground is 2 banners with the Fluorochem logo and info graphics about our service

Come and speak to us today if you're at the Chemistry symposium @ucl.ac.uk and find out how Fluorochem can support your research far beyond fluorinated compounds

#ChemSky #ucl #AcademicSky #chemistry #research 🧪

Activatable Fluorescence/Photoacoustic Macromolecular Probe for Imaging of Tumor‐Associated Natural Killer Cells An activatable near-infrared fluorescence (NIRF)/photoacoustic (PA) macromolecular probe is developed based on the optimized fluorophore scaffold with a long absorption maximum and high PA brightness...

New in chemistry, imaging and cancer

The new dye BhCyNK is designed to activate only in the presence of a specific enzyme found in tumours rich in natural killer cells. The dye produces a strong signal, helping researchers track these immune cells live, inside the body.

🧪 #Cancer #imaging

Protected amino acids - these protected forms ensure controlled stepwise synthesis, for application in solid-phase peptide synthesis (SPPS) or solution-phase methods.

Premium amino acids provide the consistency and performance your science demands.

#aminoacids #peptidesynthesis #ChemSky 🧪

Solid‐Phase Parallel Synthesis of Photocleavable Bifunctional Molecules Enables Efficient Phenotypic Protein Degrader Discovery An integrated platform enables efficient parallel solid-phase synthesis of diverse, photocleavable CRBN-focused degrader libraries. Direct-to-biology (D2B) phenotypic screening, incorporating mechani...

This study presents an integrated platform for phenotypic protein degrader discovery (PPDD)—a method particularly useful for targeting proteins that lack detailed structural or ligand-binding information.

#ChemSky #ScienceSky #AcademicSky #BioSky 🧪
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Peptide synthesis and amide bond formation are essential techniques in chemical biology.

Coupling reagents like COMU, HBTU, and HATU high efficiency, low racemization, and broad substrate compatibility make them go-to tools in both academic and industrial labs.

🧪 #ChemSky #Peptide #Biochem