Domainex Limited

If you're attending the Collaborative Drug Discovery - CDD Vault meeting next week, make sure to catch Nicholas Bland's talk on our Direct-to-Biology (D2B) platform.

Nick will be discussing how the D2B platform can be integrated into your drug discovery project.

This week is National Apprentice Week, and on Monday our biology apprentices, Rose, Chloe and Jude attended the #KentApprenticeshipAwards.

This was a great opportunity for them to get together with fellow apprentices and to celebrate success, with Rose nominated for an award.

Katie Day will be representing Domainex at the 33rd Protein Structure Determination in Industry Conference in Basel that starts on Sunday.

Don't miss her poster on Sunday evening "Using Direct-to-Biology in a Spectral Shift-PoLiPa Platform to Enable Fast Fragment Follow-Up for A2a Antagonists"

Check out our new blog, lnkd.in/esk6U9_h, by one of our scientists Alicia Overall, to find out about what the #Domainex team got up to at ELRIG.

The blog covers the team of volunteers working as Red Shirts, as well as our science presentations.

Don't miss Jonathan Powell giving a presentation at the RSC BMCS New Approaches to the Treatment of Parkinson's conference.
If you would like to find out more information about how #Domainex can advance your CNS drug discovery project, come speak to us there or get in touch enquiries@domainex.co.uk

Ray Boffey, CCO, will be at the "Bringing discoveries to life through partnerships and enterprise: How to engage with the Milner Institute" event on 3rd November.

If you are attending, look out for Ray to discuss how Domainex can help with your lead discovery challenges.

Our last poster presenter is Holly Madden, a scientist within our assay biology team, who will be at Poster 158.

Holly will be presenting "Using Direct-to-Biology in a Spectral Shift-PoLiPa Platform to Enable Fast Fragment Follow-Up for A2a Antagonists"

This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG next week, and up next is Nicholas Bland's poster.

Nick will be presenting "Unlocking RNA as a Drug Target: Novel Hit Discovery Strategies for Small Molecule Binders"

This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG.

Next up is Phil, who is presenting poster "Molecular Matchmakers: Finding the Perfect Glue".

The poster will detail our cell-free hit finding cascade to detect and characterise molecular glue activity.

This week we are highlighting the posters that the #Domainex team will be bringing to ELRIG next week.

First up is Kamini Magon, who is presenting a poster titled "Development of C5aR1 negative allosteric modulators with potential benefits for neuroinflammation".

Are you heading to ELRIG next week? Get in touch to set up a meeting with our team, and keep an eye on our socials next week to find out more about our scientists who will be attending alongside our commercial team.

Don't miss Tayo Alleyne-Weir's talk at the Annual GCI/ITC Community Meeting in Basel today.

His presentation, 'Harnessing Biophysical Methods for Hit Discovery and Validation at Domainex', will cover a case study for a difficult tpd project.

Chris Miller and Andrew Ratcliffe are at Booth 513 at #DOT2025, drop by to find out more about how we can drive your lead discovery project forward.

We'd also be delighted to discuss our #D2B services, highlighted during our talk. Looking forward to a day of good discussions.

FBLD Conference starts on Sunday in Cambridge and the #Domainex team are looking forward to attending.

Visit us at Booth 6 to catch up with Ray, Anna, Philip, Tom and Gang about our approach to fragment lead discovery and our expertise in applying our services to fragment based projects.

At #Domainex, we are continuously expanding our computational chemistry toolkit to better guide molecular design and selection. Find out more in our latest blog:
www.domainex.co.uk/news/new-pre...
#CADD #ComputationalChemistry #CompChem

Have you noticed a discrepancy in compound turnover between liver microsomes and hepatocytes, with accelerated degradation observed in hepatocyte incubations? This could be due to metabolism by aldehyde oxidase. Find out more:
www.domainex.co.uk/services/ald...
#ADME #Metabolism

Laura Lemel and Alec O'Keeffe are attending the GPCR-UK Network Meeting today. If you are there, make sure to catch up with them about how Domainex can support your GPCR project.
You can also find out more information on our website lnkd.in/ejJp-VCz or get in touch via enquiries@domainex.co.uk

Jason is attending the International Reid Bioanalytical Forum this week. He will be presenting a poster on 'The characterisation of irreversible and reversible covalent fragments using LC-MS workflows'.
Catch up with Jason at the event, or get in touch with our team at enquiries@domainex.co.uk.

#Domainex will be attending Discovery on Target in Boston from the 22nd September. Come find Chris Miller and Andrew Ratcliffe at Booth 513 if you are attending.
Don't miss AJ's talk on 'Direct-to-Biology Enabled Drug Discovery' to find out more about our #D2B platform.

Our #chemists have prepared a white paper describing how they have adopted high-throughput experimentation #HTE as part of their standard way of working and regularly use it to troubleshoot problematic reactions. A copy can be downloaded from our website:
www.domainex.co.uk/sites/defaul...

The #Domainex team are looking forward to attending the FBLD Conference later this month in Cambridge.

We are looking forward to connecting with the fragments community. Get in touch with us if you would like to set up a meeting.

Domainex will be at the RSC BMCS/SCI Medicinal Chemistry Symposium in Cambridge later this month. This is a great event to bring together experts in chemistry, with a focus on first disclosures and new strategies in the field.

Don't miss our posters which are focusing on our D2B platform.

As we head out of summer and into September, a busy conference season is upon us. The Domainex team have a busy few months of conferences ahead, with poster presentations and talks at events both in the UK and US.

Details of the events are on our website lnkd.in/eqUy8H6E.

#Domainex is delighted to announce it has joined forces with Pharmacelera to accelerate the discovery of molecules targeting transmembrane proteins.
Find out more:
www.domainex.co.uk/news/domaine...

In our latest blog, you can find out more about the Trek to Remember hike for
#AlzheimersSociety some of the #Domainex team participated in earlier this month.
www.domainex.co.uk/news/trek-re...

Congratulations to the two teams for completing the hike and raising over £4,000.

Have you got a molecular glue programme that you need support for? If so, get in touch with Domainex to find out how we can assist.

Find out more on our website: www.domainex.co.uk/services/mol...

Are you thinking of pursuing a #prodrug strategy for your drug discovery programme? If so, get in touch with #Domainex to find out how we can help or take a look at our new webpage for more information:
www.domainex.co.uk/services/pro...
#DrugDiscovery #LeadDiscovery #Prodrugs

Do you need support for your covalent inhibitor programme? Whether you need help identifying initial hits, optimising hits you've already identified, or profiling your covalent compounds, find out how we can help on our website: www.domainex.co.uk/services/cov...

At #Domainex, we have a large amount of expertise in GPCR projects.
We offer support at all stages, from initial protein production, through to assay biology and can then support a hit identification or hit-to-lead campaign.
Find out more on our website www.domainex.co.uk/services/gpcrs

We have recently updated our #ADME webpage to include details of our ChromLogD service.

ChromLogD is a fast, high-throughput alternative to the shake flask LogD. Find out more information on our website lnkd.in/ed8Ppbjk.