Alberto Mazzoni @Sant'Anna Pisa

This is my first work with a potential impact on energy efficiency and hence on climate. Following neurons' example we can find alternatives to the madness of energy-hungry AI. My environmentalist side and my neuroscientific side are both happy.

Neuromorphic architectures do not simply learn to properly decode sensory stimuli: they do it in an energy efficient way. My latest work out in @natcomms.nature.com

www.nature.com/articles/s41...

Digital twins support cross-modal and cross-centric classification of mild cognitive impairment - Communications Medicine Amato et al. evaluate whether brain digital twins can be utilized to derive robust dementia biomarkers. Biomarkers derived from digital twin outperform standard MEG and EEG metrics in diagnosing patho...

Our personalized cortical models can diagnose #dementia early using non-invasive EEG/MEG. They generalize across data from different centers and recording modalities, boosting real-world reliability. #Neurotech #digital_twins www.nature.com/articles/s43...

Transformer-based long-term predictor of subthalamic beta activity in Parkinson’s disease - npj Parkinson's Disease npj Parkinson's Disease - Transformer-based long-term predictor of subthalamic beta activity in Parkinson’s disease

aDBS revealed long-term drifts and sudden changes in #Parkinsons subthalamic activity. We propose a deep learning framework to predict them before they lead to clinical consequences

www.nature.com/articles/s41...

No Italian more than six years old will consider it a carbonara. It's like confusing a wolf with a chihuahua.

Into population dynamics? Coming to #CNS2025 but not quite ready to head home?

Come join us! at the Symposium on "Neural Population Dynamics and Latent Representations"! 🧠
📆 July 10th
📍 Scuola Superiore Sant’Anna, Pisa (and online)
👉 Free registration: neurobridge-tne.github.io
#compneuro

Alleato contro l’Alzheimer. Un modello matematico per la diagnosi precoce Sviluppato nei laboratori della Scuola Sant’Anna è capace di individuare con grande precisione l’insorgenza della malattia. Ne parliamo col suo creatore

Per i lettori italiani, qui spiego come usiamo modelli matematici per la diagnosi dell' #Alzheimer in modo divulgativo

www.lanazione.it/pisa/cronaca...

Digital twins and non-invasive recordings enable early diagnosis of Alzheimer’s disease - Alzheimer's Research & Therapy Background The diagnosis of Alzheimer’s disease (AD) in its preclinical stages, such as subjective cognitive decline (SCD), is crucial for a timely management of the condition. However, current early ...

Novel work from the Computational Neuroengineering Laboratory at Sant'Anna (Pisa)

From computational models to clinical applications: a digital twin of #Alzheimers enables prediction of individual patients' dementia evolution from non-invasive EEH recordings

link.springer.com/article/10.1...

How climate change will burden our children: data reveal a lifetime of extreme heat Young people will be exposed to a number of heatwaves that no one would have experienced in pre-industrial times.

Just over half of the children born in 2020 will face unprecedented exposure to heatwaves over their lifetime — even under a conservative projection for how climate change will unfold over the next 75 years

https://go.nature.com/3YzbUFn

Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration - Alzheimer's Research & Therapy Cognitive decline is a condition affecting almost one sixth of the elder population and is widely regarded as one of the first manifestations of Alzheimer’s disease. Despite the extensive body of know...

Our novel network model of early stages of #Alzheimer's identifies a phase transition in neurodegeneration parameters that could support early diagnosis based only on EEG recordings alzres.biomedcentral.com/articles/10....

Oscar-winning Palestinian director of ‘No Other Land’ assaulted by Israeli settlers in the West Bank | CNN The Palestinian co-director of Oscar-winning film “No Other Land” Hamdan Ballal was beaten up by Israeli settlers in the occupied West Bank and taken away by Israeli soldiers, his colleagues and eyewi...

The Palestinian co-director of Oscar-winning film "No Other Land" Hamdan Ballal was beaten up by Israeli settlers in the occupied West Bank and taken away by Israeli soldiers, his colleagues and eyewitnesses said.

Spiking Patterns in the Globus Pallidus Highlight Convergent Neural Dynamics across Diverse Genetic Dystonia Syndromes Objective Genetic dystonia is a complex movement disorder with diverse clinical manifestations resulting from pathogenic mutations in associated genes. A recent paradigm shift emphasizes the functio...

Don't forget to read the previous work about genetic profile and spiking patterns to have the complete picture

onlinelibrary.wiley.com/doi/full/10....

Genetic Etiology Influences the Low‐Frequency Components of Globus Pallidus Internus Electrophysiology in Dystonia Background Elevated low-frequency activity (4–12 Hz) within the globus pallidus internus (GPi) has been consistently associated with dystonia. However, the impacts of the genetic etiology of dystoni...

Another piece of the puzzle of the genetic aetiology of dystonia falls into place: how the genetic profile affects spectral components of globus pallidus activity.

onlinelibrary.wiley.com/doi/full/10....

Congratulations, Andreas! It's great news for European neuroscience to have you back and to have an institute dedicated to network stimulation! I hope to see you soon in Kobe and that you will tell me more about this.

Moreover, comparing our results with the literature on the efficacy of DBS in dystonia we observe that the reported efficacy seems to be proportional to the degree of burstiness associated with the genetic profile.

Briefly, neural activities recorded during pallidal DBS implant from patients with different genetic profiles converge robustly in three clusters: one tonic firing group (AOPEP, PANK2, THAP1) one bursting group (GNAL, PLAG26, KMT2B, SGCE) and one highly irregular group (TOR1A, VPS16)

Spiking Patterns in the Globus Pallidus Highlight Convergent Neural Dynamics across Diverse Genetic Dystonia Syndromes Objective Genetic dystonia is a complex movement disorder with diverse clinical manifestations resulting from pathogenic mutations in associated genes. A recent paradigm shift emphasizes the functio...

Interested in #dystonia? Wondering how so many different genes can lead to this pathology? We might have found some answers analysing neural recordings from basal ganglia. Check our latest paper just out on Annals of Neurology: onlinelibrary.wiley.com/doi/full/10....

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

Article from @science.org re: today's freeze on #NIH study sections, Council, comms, hiring, travel

www.science.org/content/arti...

Conflict of interest disclosure: I was actually born in Florence

A few days left for Tutorials and Workshops proposals submission for the 2025 meeting of the Organization for Computational Neuroscience. And this year the congress takes place in the most beautiful city of the world - you really can't miss it!

www.cnsorg.org/cns-2025

For once we disagree my friend. Every aspect of Twin Peaks S3 is pure gold, including David Lynch role as Gordon Cole. "Who is the dreamer?"

The amazing dataset of neural data from freely moving monkeys was collected by Luca Bonini's team at the University of Parma, and I performed the analysis with my incredible student Elena Hillary Rondoni from the Computational Neuroengineering Lab of Sant’Anna School of Advanced Studies in Pisa

Neuroethology of natural actions in freely moving monkeys The current understanding of primate natural action organization derives from laboratory experiments in restrained contexts (RCs) under the assumption that this knowledge generalizes to freely moving ...

First post on @bsky.app to announce my first paper published @science.org!

How much do we know about how the cortex encodes the same movement when it is performed in arbitrarily different contexts? Find out here:

www.science.org/doi/10.1126/...