Tom Nolan

How effective are de-implementation strategies to reduce low value care? Aleksi Raudasoja and colleagues conducted a systematic review and meta analysis to find out. 🧵

Between promise and peril: role of suzetrigine as a non-opioid analgesic In the current landscape of the opioid crisis, which was responsible for over 100,000 overdose deaths in the United States in 2022 alone, interest in the development of non-opioid analgesics has been ...

"The opioid crisis warrants innovation in drug development, but not at the cost of repeating history" concludes an editorial in BMJ Medcine about suzetrigine, the non-opioid analgesic recently approved by the FDA bmjmedicine.bmj.com/content/4/1/...

Benefits, burden, and harms of computer aided polyp detection with artificial intelligence in colorectal cancer screening: microsimulation modelling study Objective To estimate the benefits, burden, and harms of implementing computer aided detection (CADe) of polyps in colonoscopy of population based screening programmes for colorectal cancer.Design Mic...

CADe in population based screening “provides small and uncertain clinical meaningful benefit, no incremental harms, and increased surveillance burden" according to a microsimulations study in BMJ Medicine that informed the Rapid Recommendations guideline. bmjmedicine.bmj.com/content/4/1/...

Computer aided detection and diagnosis of polyps in adult patients undergoing colonoscopy: a living clinical practice guideline Clinical question In adult patients undergoing colonoscopy for any indication (screening, surveillance, follow-up of positive faecal immunochemical testing, or gastrointestinal symptoms such as blood ...

A new guideline in the BMJ recommends against the routine use of AI powered computer aided detection (CADe) systems to assist colonoscopy. www.bmj.com/content/388/...

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New paper in @bmj.com. Ever been told ‘what does your DAG say?” or “show me your DAG”, or “ok draw a DAG” and not sure what that means or how to get started? Well buckle up, because Fernando Hartwig, @neilmdavies.bsky.social and I wrote an RMR on just this topic. www.bmj.com/content/388/...