Kristoffer Stewart

Excited to be at #esmo! Though there is so much on the agenda I don't know where to begin - suggestions are welcome!
@myesmo.bsky.social

Inferior control arms in oncology trials in LMICs: contextualised or compromised? In recent years, cancer drug randomised controlled trials (RCTs) have been criticised for employing a control arm treatment that is inferior or suboptimal to the existing standard of care.1 2 Using an...

✅ Highlights the urgent need for equity & global trial harmonization.

❓ Question to think: Should trial standards always reflect the best global care — or adapt to local realities?

#OncoEthics #GlobalOncology #ClinicalTrials #OncoTwitter #Medicalwatch
bmjoncology.bmj.com/content/4/1/...

Novel radiopharmaceuticals for molecular imaging of renal cell carcinoma Conventional diagnostic strategies for imaging patients with renal cell carcinoma (RCC) have predominantly relied on ultrasonography, CT and MRI. However, a paradigm shift is underway with the emergen...

Really excited to see this paper live on BMJ Oncology!

The authors have provided a comprehensive overview of novel radiopharmaceuticals for molecular imaging of renal cell carcinoma🔬

bmjoncology.bmj.com/content/4/1/...
#radiation #kidneycancer #oncology

Really excited to see this paper live on BMJ Oncology!

The authors have provided a comprehensive overview of the tumour-infiltrating lymphocyte therapy landscape, and their work will be a valuable resource for the field 🔬

bmjoncology.bmj.com/content/4/1/...
#immunotherapy #immunology #oncology

Jobs and careers with BMJ Group Jobs and careers with BMJ Group -

We're hiring a new clinical editor to join our team and support the launch of a new journal, BMJ Surgery

Clinical Editor - BMJ Surgery
£69,632 (pro-rata 0.4fte)
London, Hybrid
jobsearch.bmj.com/jobs/latest
If you want to know more email kstewart@bmj.com

Mismatch in testing: a retrospective analysis of mismatch repair testing in endometrial cancer and Lynch syndrome diagnosis in multiple specialist centres in the UK and Ireland (March 2022–March 2023) Objectives To assess the implementation of Lynch syndrome testing in endometrial cancer (EC) across the UK and Ireland, identify diagnostic gaps and evaluate adherence to the National Institute for He...

Significant gaps in testing for #lynchsyndrome #hereditarycancer risk, UK study finds @bmj.com

#cancerresearch #oncsky #openaccess

Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity Cancer remains one of the most formidable challenges in modern medicine, due to its complex and dynamic nature, which demands innovative therapeutic approaches. One major challenge to cancer treatment...

Can targeted therapies towards the hypoxia-inducible factor (HIF) pathway enhance the potency of current cancer treatments? This review explores the science:
bmjoncology.bmj.com/content/3/1/...
#cancer #hypoxia #oncology

Specificity of Food and Drug Administration postmarketing requirements and associations with timely submissions and regulatory decisions for oncology accelerated approvals, 2011–2023: a cross-sectiona... Objectives To assess the specificity of postmarketing requirement (PMR) statements and associations between PMR statement specificity and PMR study characteristics, timeliness and regulatory decisions...

New pub on cancer accelerated approvals in which we find: 1) PMR statements often lack specificity on key study design elements and 2) less stringent specs in PMR statements are associated with on-time submission, potentially trading rigor for speed. bmjoncology.bmj.com/content/4/1/...

I'm wondering if I can get some help with the kind people of @bsky.app. I'm trying to compile a list of key conferences across the broad field of #immunology - if you have any thoughts please reply or directly message.

All suggestions welcome!👍

Air pollution and its impact on cancer incidence, cancer care and cancer outcomes Air pollution is an under-recognised global health threat linked to an increased risk of cancers and is due primarily to the burning of fossil fuels. This review provides a high-level overview of the ...

BMJ Oncology features research from OUCH members Dr. Roselle De Guzman & Dr. Joan Schiller on how pollutants contribute to cancer incidence and outcomes. Cleaner air isn't just an environmental issue; it's a public health necessity.

Read more: bmjoncology.bmj.com/content/4/1/...
#CancerResearch

Innovations in #clinical #education - great opportunity to listen to ways to maximise learning for students across #healthcare #crtitical
#thinking and #creative #arts. Don’t miss it 👇 @radchat.bsky.social @journal-kristoffer.bsky.social @yattsang.bsky.social @gerryhanna.bsky.social

Happy PM day to all who celebrate! PubMed, that is. BMJ Oncology is proud to announce that all our content is now available on PubMed! 🎉 🍾 🥂 @journal-kristoffer.bsky.social @mazer.us @eabhalynn.bsky.social @oncoalert.bsky.social

The study suggests it is necessary to conduct prospective life-course cohort studies to explore the aetiologies of early-onset cancers, and countries should adjust prevention strategies based on the characteristics of early-onset cancer.

Early-onset breast, tracheal, bronchus and lung, stomach and colorectal cancers showed the highest mortality and burden in 2019
@oncoalert.bsky.social

Dietary risk factors (diet high in red meat🥩, low in fruits🍎, high in sodium🧂 and low in milk🥛, etc), alcohol consumption 🍺and tobacco 🚬use are the main risk factors underlying early-onset cancers
#cancer #oncology #globalhealth

Global trends in incidence, death, burden and risk factors of early-onset cancer from 1990 to 2019 Objective This study aimed to explore the global burden of early-onset cancer based on the Global Burden of Disease (GBD) 2019 study for 29 cancers worldwid.Methods and analysis Incidence, deaths, dis...

A study by Zhao et al. showed that since 1990, the incidence and deaths of early onset cancers have substantially increased globally🌍🌏🌍

Countries with a high-middle and middle Sociodemographic Index and individuals aged 40–49 years were particularly affected

bmjoncology.bmj.com/content/2/1/...

I think this is great!

If you want @bsky.app to continue to grow then give the big publishing bodies an excuse to back this app - share research and click on research. #research #oncology

This is a true testament to how I think this platform differs - I don't know this account, but just check out how wholesome it is as a concept 🥰

I look forward to following, committing to reading the book and
inevitably letting everyone down 😅
@oncologybookclub.bsky.social @bsky.app

Flash backs to university when my friends who left their dissertation write-up and submission to the final minute and did better than me 😆

Do shortcuts leave older patients short changed? The UK TOASTIE study Some decision-making in medicine is easy. Facilitated by clear guidance, powerful evidence and strong opinion we can often reassure our patients that a therapeutic choice is the right one. Things are ...

If you want an overview of the field and some context for this research, check out @bmj-oncology.bsky.social's paired editorial by @breastdocuk.bsky.social & Nicolò Matteo Luca Battisti

"Do we need better scoring systems or better approaches?"

bmjoncology.bmj.com/content/3/1/...
#cancer #oncology

UK national observational cohort study investigating Tolerance of Anti-cancer Systemic Therapy in the Elderly: the TOASTIE study Objective The Cancer and Aging Research Group (CARG) score was developed to predict severe chemotherapy-induced toxicity risk in older adults; validation study results have varied. The Tolerance of An...

📣 Check out this recent study:

UK national observational cohort study investigating Tolerance of Anti-cancer Systemic Therapy in the Elderly: the TOASTIE study

From @drmarkbaxter.bsky.social and colleagues: bmjoncology.bmj.com/content/3/1/...
#cancer #chemotherapy

We are working on a whole new set of courses on #palliativecare for BMJ Learning, starting with this one on pain management.

If you want to know more, please contact: @journal-kristoffer.bsky.social

I clicked through into this special issue and nearly every article drew me in, such an interesting array of work.

Give it a click this Friday afternoon and treat yourself to a bit of insight! 💻📱

Well done to all involved 👏

BMJ Oncology - Patient toxicities

Are we overlooking cancer's hidden toxicities?
🧠Mental health strain
💰 Financial burdens
⏳ Logistical chaos

Should addressing these be as routine as managing the tumor itself?
#Oncology #CancerCare

Check out this paper by BMJ ONC's patient advocate Rick Bangs:
bmjoncology.bmj.com/content/3/1/...

Yes of course, you can do it here: mc.manuscriptcentral.com/bmjonc

You can find out more about the journal here:
bmjoncology.bmj.com/pages/about

We're an open access journal with a focus on publishing content that optimises cancer patient care and outcomes

Patient and public partnership - BMJ Author Hub

This is one of the reasons why it is so important to include the patients at an early stage in healthcare and research. At @bmj.com we are trying to encourage partnering with patients and the public to improving the quality, safety and value authors.bmj.com/policies/pat...

Bedside implications of the use of surrogate endpoints in solid and haematological cancers: implications for our reliance on PFS, DFS, ORR, MRD and more Clinical endpoints, such as overall survival, directly measure relevant outcomes. Surrogate endpoints, in contrast, are intermediate, stand-in measures of various tumour-related metrics and include tu...

Clinical endpoints (eg survival) measure real outcomes, but surrogate endpoints (eg tumor shrinkage) often fall short of predicting outcomes
Can misuse of surrogates in trials harm patients? Are we too reliant on surrogates?
bmjoncology.bmj.com/content/3/1/...
@vinayprasadmdmph.bsky.social #Oncology

Amazing thank you!

Couldn't agree more!👏

The joy of not having to scroll past adverts, promoted content and boosted profiles on x!

I'm excited to dive deeper and connect with those excited about sharing their ideas, work and enthusiasm!