haysamrady

Lecithin-cholesterol acyltransferase deficiency with the finding of “zebra bodies”: A diagnostic challenge in the context of suspected Fabry disease Lecithin-cholesterol acyltransferase (LCAT) deficiency is a rare autosomal recessive disorder resulting from mutations in the LCAT gene, which leads t…

Lecithin-cholesterol acyltransferase deficiency with the finding of “zebra bodies”: A diagnostic challenge in the context of suspected Fabry disease
#nephsky #nephrology
www.sciencedirect.com/science/arti...

Bx in older F pt for subnephrotic proteinuria reveals numerous myelin figures in podocytes. Concern for Fabry + other genetic diseases. Subsequently learned the pt was on long term to Plaquenil. Genetics pending, but may all be HCQ tox. #renalpath #pathsky #nephsky

An NGS-based investigation of copy number variants in the diagnosis and severity of adult polycystic kidney disease Patients were recruited from Beaumont Hospital, Dublin, Ireland as a part of the Irish Kidney Gene Project (IKGP) [30]. To qualify for inclusion, patients had to be clinically diagnosed with PKD using the unified criteria for ultrasonography diagnosis of ADPKD or having evidence of >5 cysts [31] and have WES or TGP data available. Participants must have undergone CT, MRI or ultrasound imaging of their abdomen to assess for kidney and liver cysts. During recruitment, patients were given an individual ID and a family ID to allow for segregation analysis of identified variants. Individuals with a known familial connection (i.e. through a pedigree) were assigned the same family ID. Clinical records were used to gather information on age at kidney failure, height-adjusted total kidney volume (htTKV), and presence or absence of liver cysts. Kidney failure was defined as the need for dialysis or pre-emptive kidney transplantation. HtTKV was estimated by calculating the total kidney volume from imaging data correcting for height of the patient [32]. The occurrence of liver cysts was evaluated based on imaging report by expert clinical radiologist. Short-read sequencing data Sequencing of the patients was performed on whole blood as a part of the IKGP. Of the...

An NGS-based investigation of copy number variants in the diagnosis and severity of adult polycystic kidney disease
->Nature | More on "Polycystic kidney disease genetic diagnosis" at BigEarthData.ai | #Health #Disease

🧪 Acid–base basics

https://youtu.be/wW-I2GX9rlE

pH regulation, buffering systems, bicarbonate–CO₂ & clinical correlations

🔬 ABC Kidney series www.abckidney.com for immersive experience! 👈

#Nephrology #FOAMed #AcidBase #ABG #MedEd #Physiology

Generic controlled-release budesonide in IgA nephropathy – a single center retrospective study IgA nephropathy(IgAN) is the most common primary glomerular disease in adults worldwide. It has a smouldering trajectory with significant risk of progressive kidney failure. Recent breakthroughs have ...

Generic controlled-release budesonide in IgA nephropathy – a single-centre retrospective study
#nephsky #nephrology
www.kireports.org/article/S246...

Major changes to type 2 diabetes treatment could save thousands of lives

New NICE guidance to transform treatment for people living with type 2 diabetes by providing earlier access to vital drugs that protect the heart and kidneys from diabetes related complications
www.nice.org.uk/news/article...

Sex Hormones and Effects on Kidney Health: Piecing Together the Science Studies in the general population and individuals with chronic kidney disease (CKD) show that men experience greater declines in kidney function with age and progress to end-stage kidney disease…

In the Literature by @estrella_khrc:

Sex Hormones and Effects on Kidney Health: Piecing Together the Science

Implementation of a Protocol With a Shortened Vancomycin Prophylaxis Duration is Associated With Reduced Acute Kidney Injury in Lung Transplant Recipients: A Quasi‐Experimental Study We evaluated implementation of a shortened post-operative vancomycin prophylaxis duration protocol on acute kidney injury (AKI) in lung transplant recipients. The intervention, modifying vancomycin (...

A shortened 72-hour vancomycin prophylaxis protocol in lung transplant recipients was associated with lower odds of acute kidney injury — with similar infectious outcomes.

Research from WSU EACPHS.

#AntimicrobialStewardship #TransplantMedicine

doi.org/10.1111/tid....

Alport syndrome is a frequent cause of hereditary glomerulonephritis, and some pathogenic variants affect splicing.

Here, Hassan Saei @hassansaei.bsky.social & team establish a kidney organoid platform of AS & correct gene splicing using ASO therapy: doi.org/10.1172/jci....

Capillary refill time (CRT) measured in digital nail bed blood return is quick, easily performed, and a long-standing component of the physical exam in the ICU
#Nephpearls #AKIinICU #NephSky

👉 www.wolterskluwer.com/en/solutions...
👉 pubmed.ncbi.nlm.nih.gov/30772908/

Obinutuzumab works in membranous!

Genentech is shooting fish in a barrel. Every disease that responds to Ritux is going to be in their sights.

www.nasdaq.com/articles/gen...

Health Watch USA to Examine COVID-19 Vaccination and Kidney Disease Outcomes | Infection Control Today Join Health Watch USA on February 18, 2026, as Christos Argyropoulos, MD, PhD, MS, FASN, discusses how repeated COVID-19 vaccinations compare with COVID-19 disease in patients with kidney disease,…

I will be talking later today (February 18th) about #COVID19 infection & vaccination kidney outcomes. This is work done with electronic health records (#TrinetX) by our group that was presented at the ASN #KidneyWk 2025.
Announcement and zoom link
www.infectioncontroltoday.com/view/health-...

Osteoporosis & CKD-MBD under the Same Umbrella: Insights From a Joint Scientific Symposium Osteoporosis and Chronic Kidney Disease–Metabolic Bone Disease (CKD-MBD) are increasingly recognized as overlapping conditions, particularly in the aging population. Declining renal function and skele...

Osteoporosis & CKD-MBD under the Same Umbrella: Insights From a Joint Scientific Symposium
#nephsky #nephrology
www.kireports.org/article/S246...

Canadian Society of Nephrology Commentary on the Evolving Kidney Disease Improving Global Outcomes Adult Glomerulonephritis Guidelines - PubMed The commentary aims to provide tailored guidance to enhance the care of Canadians living with glomerular disease.

Canadian Society of Nephrology Commentary on the Evolving Kidney Disease Improving Global Outcomes Adult Glomerulonephritis Guidelines

Figure 2. Pros and cons of albuminuria in diagnosis and prognosis of kidney diseases. The figure shows a schema c of a glomerulus and the filtra on of low molecular proteins, albumin and high molecular weight immunoglobulins in glomerular disease. Also showed are the pros and cons of the measurement of albuminuria compared to proteinuri

Albuminuria or proteinuria?

the European GN workgroup sees to hedging, proteinuria now, maybe albuminuria later

more research is needed™️

academic.oup.com/ndt/advance-...

Stone prevention algorithm for most and Ca stones

Stone prevention algorithm for uric acid and cystine

Stone prevention algorithm for most and Ca stones

Australian guidelines on stone prevention in KI Reports

www.kireports.org/article/S246...

What do you think @weddelite.bsky.social?

In a renal transplant recipient, what is your diagnosis?

#DiagnoseThis #nephsky #pathsky #renal #kidneypath

Low-density lipoprotein apheresis for recurrent focal segmental glomerulosclerosis in pediatric kidney transplant recipients: a systematic review and meta-analysis - Pediatric Nephrology Background Recurrent focal segmental glomerulosclerosis (rFSGS) is a significant cause of graft failure in pediatric patients. Low-density lipoprotein apheresis (LDL-A) is an FDA-approved treatment…

Low-density lipoprotein apheresis for recurrent focal segmental glomerulosclerosis in pediatric kidney transplant recipients: a systematic review and meta-analysis

Figure 3 (a) Acute Phase: Mean (+/-SD) Serum Potassium by Time for WS016 3g and Placebo. (b) Maintenance Phase: Mean (+/-SD) Serum Potassium by Day for WS016 3g and Placebo. (c) Acute Phase: Mean (+/-SD) Serum Potassium by Time for WS016 6g and Placebo. (d) Maintenance Phase: Mean (+/-SD) Serum Potassium by Day for WS016 6g and Placebo. (e) Acute Phase: Mean (+/-SD) Serum Potassium by Time for WS016 12g and Placebo. (f) Maintenance Phase: Mean (+/-SD) Serum Potassium by Day for WS016 12g and Placebo. After 48 hours of acute treatment, the mean serum potassium levels in the WS016 groups were 4.72 mmol/L (3 g), 4.79 mmol/L (6 g), and 4.57 mmol/L (12 g), all within the normal range (3.5–5.0 mmol/L), compared with 5.08 mmol/L in the placebo group. Following maintenance treatment, mean serum potassium levels were 4.84, 4.79, and 4.99 mmol/L in the WS016 12 g, 6 g, and 3 g groups, respectively, compared to 5.11, 5.14, and 4.92 mmol/L in their corresponding placebo groups.

new K resin drop from China WS016, seems like a Na/Ca cation exchange resin
~ 0.5 to 0.9 mmol/L decrease in K, and seems to be somewhat fast

very convoluted phase 2 study in KI Reports www.kireports.org/article/S246...

A Case Series of Elevated Donor-Derived Cell-Free DNA Leading to Diagnosis of Post-Transplant Glomerulonephritis No prior associations between elevated donor-derived cell-free DNA (dd-cfDNA) levels and glomerulonephritis (GN) in kidney transplant recipients have been reported. We present 3 cases of post-transpla...

A Case Series of Elevated Donor-Derived Cell-Free DNA Leading to Diagnosis of Post-Transplant Glomerulonephritis
#nephsky #nephrology
www.kidneymedicinejournal.org/article/S259...

New hope for recurrent FSGS after kidney transplant: Targeting B cells and plasma cells with rituximab + daratumumab led to remission and improved kidney function in patients who hadn’t responded to standard therapies. #TXPforAll tinyurl.com/3nxrupcs

Novartis Vanrafia® Phase III data support slowing of kidney function decline in patients with IgA nephropathy - United Kingdom East Hanover, February 13, 2026 – Novartis today announced final results from the Phase III ALIGN study supporting a slowing decline in kidney function in

Novartis Vanrafia® Phase III data support slowing of kidney function decline in patients with IgA nephropathy

https://www.europesays.com/uk/761771/

In ALIGN study, Vanrafia (atrasentan) showed positive difference in eGFR change from baseline vs. placebo at Week 136,…#uk #news #uknews

Kidney patient forced to wait for someone to die to be able go home Kimberley resident David Lawford had to wait in Perth until someone in his hometown died before he could get access to dialysis on his return.

Kimberley resident David Lawford had to wait in Perth until someone in his hometown died before he could get access to dialysis on his return.

Regulation of Blood Pressure and Salt Balance By Pendrin-Positive Intercalated Cells: Donald Seldin Lecture 2020 | Hypertension Intercalated cells make up about a third of all cells within the connecting tubule and the collecting duct and are subclassified as type A, type B and non-A, non-B based on the subcellular distributio...

fun review if anyone is interested www.ahajournals.org/doi/10.1161/...

Vaughan Pendred was a house surgeon at Guy's hospital when he reported deaf-mutism with goitre www.sciencedirect.com/science/arti... in @thelancet.com - and went on to become a ....(not nephrologist) a general practitioner

Imaging Studies of the Abdomen and Pelvis. A three-dimensional volume-rendered image of the abdominal aorta and iliac arteries (Panel A) shows no evidence of stenosis or renal-artery abnormalities. An axial CT image, obtained in the portovenous phase after the administration of intravenous contrast material (Panel B), reveals a hypoenhancing, partially exophytic mass in the left kidney (arrow). A sagittal image obtained from contrast-enhanced CT in the portovenous phase (Panel C) shows the same lesion (white arrow), with a more hypodense focus along its superior margin (black arrow). An axial T1-weighted MRI, obtained after the administration of intravenous contrast material (Panel D), shows a hypointense, hypoenhancing lesion in the left kidney (arrow). A coronal T2-weighted MRI (Panel E) shows the lesion with predominantly hypointense signal (white arrow) and a small superior cystic component (black arrow).

a young woman with hypertension and hypokalemia, which is not PA! or FMD...

www.nejm.org/doi/full/10.... in @nejm.org

Silica Nephrolithiasis From Commonly Used Over-the-Counter Vitamins and Supplements: A Case Report | Annals of Internal Medicine: Clinical Cases Silica and calcium carbonate are very rare constituents of renal calculi, historically associated with chronic ingestion of magnesium trisilicate. We present a case of silica and calcium carbonate fir...

supplements are mostly useless, and sometimes dangerous?

stones of silica?

www.acpjournals.org/doi/10.7326/...

what do you make of this @weddellite.bsky.social ? there is a similar @ajkd.bsky.social case report too pubmed.ncbi.nlm.nih.gov/19100669/

Seronegative Cryoglobulinemic Glomerulonephritis Coexisting With Primary Sjögren’s Syndrome and HBV Infection: A Diagnostic and Therapeutic Challenge Cryoglobulinemic glomerulonephritis (CryoGN) is most often caused by mixed cryoglobulinemia (MC), encompassing both type II and type III forms. CryoGN is commonly associated with HCV infection or prim...

Seronegative Cryoglobulinemic Glomerulonephritis Coexisting With Primary Sjögren’s Syndrome and HBV Infection: A Diagnostic and Therapeutic Challenge
#nephsky #nephrology
www.kidneymedicinejournal.org/article/S259...

Proud today to share our latest work showing in vivo evidence that podocyte-derived ET-1 activating GEC ETA drives glomerular injury in FSGS. Congrats Liping Yu & @ubonge.bsky.social and big thanks to all co-authors for this tremendous team effort. #FSGS #nephrology #daehnlab @kidneyint.bsky.social

T2h
🔍🧠📊 Tubular sodium handling was… unexpected.
Despite robust glucosuria, FENa, FELi, and distal sodium reabsorption did NOT differ vs placebo.
Volume effects were present:
✔️ Increased 24-h urine volume
✔️ Sustained glucosuria at both 1 and 12 weeks. #NephJC

Oxalate nephropathy from cashew nut intake A 63-year-old woman was referred to a nephrologist for evaluation of decreased kidney function. The patient had no specific urinary symptoms or history of recurrent urinary tract infections, leg edema...

related case reports

cashews www.cmaj.ca/content/189/... in @cmaj.ca
Iced tea in @nejm.org www.nejm.org/doi/10.1056/...