Checkout this really cool di-gembodies 💎✨(aka di-gluebodies) technology by my colleague Mingda Ye and friends Gangshun and Dimitrios. By glueing two nanobodies together🔗, they managed to increase the size of protein complexes which helped to achive high resolution reconstructions 🔬🥶🔬🥶🔬🥶

15.08.2025 13:55 — 👍 2    🔁 0    💬 0    📌 0

Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇

For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too!

www.mdc-berlin.de/postdocs#t-g...

04.08.2025 10:23 — 👍 11    🔁 8    💬 0    📌 0

Principal Scientist - Computational Chemistry

Opportunity for computational chemist at Syngenta (Bracknell UK) #agrochem #CompChem #cheminformatics #AI #ML #UKChemJobs #ChemJobs #chemsky 🧪
jobs.syngenta.com/job/principa...

01.07.2025 06:32 — 👍 6    🔁 5    💬 0    📌 0

Photo of a Sauer Membrane Protein group party, why space for a new hire

Join our group in the Centre for Medicines Discovery at Oxford Univ. @cmd.ox.ac.uk @ox.ac.uk !!!!

Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa.

Please RT!

my.corehr.com/pls/uoxrecru...

03.06.2025 11:18 — 👍 9    🔁 6    💬 1    📌 1

Scientists Unveil the Structure of the Receptor Responsible for How We Taste Sweetness | HHMI HHMI Investigator Charles Zuker and his lab are exploring how detection – of a taste or other sense – is transformed into perception.

Scientists Unveil the Structure of the Receptor Responsible for How We Taste Sweetness
www.hhmi.org/news/sc...
Explore the structures in 3D at RCSB PDB:
go.rutgers.edu/6ggjdnag

20.05.2025 19:12 — 👍 3    🔁 1    💬 0    📌 0

look at this, its a really amazing preprint from Jana @janakroll.bsky.social and Co!

12.02.2025 23:45 — 👍 12    🔁 2    💬 0    📌 0

Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 - Nature Communications SPNS2 exports S1P and FTY720-P to control immune cell migration. Here, the authors use cryo-EM, immunofluorescence, in vitro binding and in vivo S1P export, and MD simulations to uncover the mechanism...

Our SPNS2 paper is published! A massive collaboration of Resolute, Oxford CMD, Nuvisan, @oxfordbiochemistry.bsky.social, CeMM, Bayer, & Univ. of Zurich

Work of many talented colleagues, including @sykhalid.bsky.social @supertifurgalab.bsky.social and numerous others

www.nature.com/articles/s41...

16.01.2025 18:17 — 👍 22    🔁 6    💬 0    📌 1

Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures Skeletal muscle contraction is mediated by acetylcholine (ACh) binding to its ionotropic receptors (AChRs) at neuromuscular junctions. In myasthenia gravis (MG), autoantibodies target AChRs, disruptin...

Pretty excited about this work looking at high-resolution mechanisms involved in the autoimmune disease myasthenia gravis! Please read our pre-print :D www.biorxiv.org/content/10.1...

21.12.2024 19:30 — 👍 7    🔁 1    💬 0    📌 1

Structures of the human adult muscle-type nicotinic receptor in resting and desensitised states Muscle-type nicotinic acetylcholine receptor (AChR) is the key signalling molecule in neuromuscular junctions. Here we present the structures of full-length human adult receptors in complex with Fab35...

Now online! Anna’s fantastic work on the structure of the Human adult Muscle-type nicotinic receptor.

Wonderful collab with Yin Dong at the @imm.ox.ac.uk

www.biorxiv.org/content/10.1...

16.12.2024 21:20 — 👍 24    🔁 9    💬 4    📌 2